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PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

http://www.wikidata.org/entity/Q27648758

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Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder Assembly of allosteric macromolecular switches: lessons from PKA Contribution of Non-catalytic Core Residues to Activity and Regulation in Protein Kinase A Novel Isoform-Specific Interfaces Revealed by PKA RIIβ Holoenzyme Structures Structure of Yeast Regulatory Subunit: A Glimpse into the Evolution of PKA Signaling Realizing the Allosteric Potential of the Tetrameric Protein Kinase A RIα Holoenzyme Localization and quaternary structure of the PKA RI holoenzyme Crystal Structure of cGMP-Dependent Protein Kinase Reveals Novel Site of Interchain Communication A Conserved Glu–Arg Salt Bridge Connects Coevolved Motifs That Define the Eukaryotic Protein Kinase Fold Structure and Allostery of the PKA RII Tetrameric Holoenzyme Implementing Fluorescence Anisotropy Screening and Crystallographic Analysis to Define PKA Isoform-Selective Activation by cAMP Analogs Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation PKA RIα Homodimer Structure Reveals an Intermolecular Interface with Implications for Cooperative cAMP Binding and Carney Complex Disease Evolutionary paths of the cAMP-dependent protein kinase (PKA) catalytic subunits Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme Protein kinases: evolution of dynamic regulatory proteins A generalized allosteric mechanism for cis-regulated cyclic nucleotide binding domains.A-kinase anchoring in dendritic cells is required for antigen presentation Protein kinase A type I activates a CRE-element more efficiently than protein kinase A type II regardless of C subunit isoform.Regulation of cAMP-dependent protein kinases: the human protein kinase X (PrKX) reveals the role of the catalytic subunit alphaH-alphaI loop.Dynamic architecture of a protein kinase.Epac and PKA: a tale of two intracellular cAMP receptors.Mechanism of Epac activation: structural and functional analyses of Epac2 hinge mutants with constitutive and reduced activities A helix scaffold for the assembly of active protein kinases Signaling through cAMP and cAMP-dependent protein kinase: diverse strategies for drug design.The switch helix: a putative combinatorial relay for interprotomer communication in cGMP-dependent protein kinase.Distal recognition sites in substrates are required for efficient phosphorylation by the cAMP-dependent protein kinase.Local cAMP signaling in disease at a glance Mode of action of cGMP-dependent protein kinase-specific inhibitors probed by photoaffinity cross-linking mass spectrometry.PKA regulatory IIα subunit is essential for PGD2-mediated resolution of inflammation.Enhanced cAMP-stimulated protein kinase A activity in human fibrolamellar hepatocellular carcinoma.cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies.A frontier in the understanding of synaptic plasticity: solving the structure of the postsynaptic density.Targeting protein kinase A in cancer therapy: an update.Leptin potentiates antiproliferative action of cAMP elevation via protein kinase A down-regulation in breast cancer cells.Glycogen synthase kinase 3beta interaction protein functions as an A-kinase anchoring protein.A chimeric mechanism for polyvalent trans-phosphorylation of PKA by PDK1.PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.Novel isoform of the Xenopus tropicalis PKA catalytic alpha subunit: An example of alternative splicing.Discovery of Allostery in PKA Signaling.

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P2860

PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

http://www.wikidata.org/entity/Q27648758

description

2007 nî lūn-bûn

@nan

2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

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PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

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PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

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type

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PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

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PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

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PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

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prefLabel

PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

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PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

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PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

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SCIENCE.1146447

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P1476

PKA type IIalpha holoenzyme reveals a combinatorial strategy for isoform diversity

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P2093

Jian Wu

http://www.w3.org/2001/XMLSchema#string

Susan S Taylor

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Sventja von Daake

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P2860

Molecular basis for regulatory subunit diversity in cAMP-dependent protein kinase: crystal structure of the type II beta regulatory subunit

Crystal structure of a transition state mimic of the catalytic subunit of cAMP-dependent protein kinase

Dynamic features of cAMP-dependent protein kinase revealed by apoenzyme crystal structure

PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

Regulatory subunit of protein kinase A: structure of deletion mutant with cAMP binding domains

Crystal structure of a complex between the catalytic and regulatory (RIalpha) subunits of PKA

Dissecting cAMP binding domain A in the RIalpha subunit of cAMP-dependent protein kinase. Distinct subsites for recognition of cAMP and the catalytic subunit.

The cAMP binding domain: an ancient signaling module.

Capturing cyclic nucleotides in action: snapshots from crystallographic studies.

The essential role of RI alpha in the maintenance of regulated PKA activity.

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274-279

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scholarly article

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10.1126/SCIENCE.1146447

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5848

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318

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Simon H J Brown

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2007-10-01T00:00:00Z

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17932298

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4036697

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