about
sameAs
Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide BiosynthesisCyclization of aromatic polyketides from bacteria and fungiClassification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains.Insights into radicicol biosynthesis via heterologous synthesis of intermediates and analogsEngineered polyketide biosynthesis and biocatalysis in Escherichia coli.Demonstration of starter unit interprotein transfer from a fatty acid synthase to a multidomain, nonreducing polyketide synthase.New insights into the formation of fungal aromatic polyketides.Synthetic strategy of nonreducing iterative polyketide synthases and the origin of the classical "starter-unit effect".Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.Engineering of an "unnatural" natural product by swapping polyketide synthase domains in Aspergillus nidulansA polyketide macrolactone synthase from the filamentous fungus Gibberella zeaeEngineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.Heterologous expression systems for polyketide synthases.Functional analysis of fungal polyketide biosynthesis genes.Rational domain swaps reveal insights about chain length control by ketosynthase domains in fungal nonreducing polyketide synthases.A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases.Strategies for mining fungal natural products.Explorations of fungal biosynthesis of reduced polyketides - a personal viewpoint.Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers.Enzymatic synthesis of resorcylic acid lactones by cooperation of fungal iterative polyketide synthases involved in hypothemycin biosynthesis.Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming.Complete reconstitution of a highly reducing iterative polyketide synthase.Engineering microbial cells for the biosynthesis of natural compounds of pharmaceutical significance.Navigating the fungal polyketide chemical space: from genes to molecules.Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase.Combinatorial domain swaps provide insights into the rules of fungal polyketide synthase programming and the rational synthesis of non-native aromatic products.A thioesterase from an iterative fungal polyketide synthase shows macrocyclization and cross coupling activity and may play a role in controlling iterative cycling through product offloading.Redirecting the cyclization steps of fungal polyketide synthase.
P2860
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P2860
description
chemesch Verbindung
@lb
chemical compound
@en
chemical compound
@en-ca
chemical compound
@en-gb
chemická sloučenina
@cs
chemická zlúčenina
@sk
chemiese verbinding
@af
chemische Verbindung
@de
chemische Verbindung
@de-ch
chemische verbinding
@nl
name
bikaverin
@en
bikaweryna
@pl
type
label
bikaverin
@en
bikaweryna
@pl
altLabel
6,11-Dihydroxy-3,8-dimethoxy-1-methyl-10H-benzo[b]xanthene-7,10,12-trione
@en
Lycopersin
@en
prefLabel
bikaverin
@en
bikaweryna
@pl
P592
P661
P662
P665
P683
P1579
P2064
P2067
382.068867
P231
33390-21-5
P232
P233
CC1=CC(=CC2=C1C(=O)C3=C(O2)C(=C4C(=C3O)C(=O)C=C(C4=O)OC)O)OC
P234
1S/C20H14O8/c1-7-4-8(26-2)5-10 ...... )20(15)28-10/h4-6,24-25H,1-3H3
P235
ZOQMSOSJEWBMHP-UHFFFAOYSA-N
P2566
100.230.205
P274
P2840
P3117
DTXSID80187020
P592
CHEMBL373432