Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.
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Structural and Biochemical Characterization of ZhuI Aromatase/Cyclase from the R1128 Polyketide PathwayInsight into the Molecular Basis of Aromatic Polyketide Cyclization: Crystal Structure and in Vitro Characterization of WhiE-ORFVIEngineering microbial factories for synthesis of value-added productsSynthetic biology approaches in drug discovery and pharmaceutical biotechnology.Structural enzymology of polyketide synthases.Cyclization of aromatic polyketides from bacteria and fungiClassification, prediction, and verification of the regioselectivity of fungal polyketide synthase product template domains.Engineered polyketide biosynthesis and biocatalysis in Escherichia coli.Fine-Tuning of the Fatty Acid Pathway by Synthetic Antisense RNA for Enhanced (2S)-Naringenin Production from l-Tyrosine in Escherichia coliAlternative sigma factor over-expression enables heterologous expression of a type II polyketide biosynthetic pathway in Escherichia coli.New insights into the formation of fungal aromatic polyketides.Interrogation of global active site occupancy of a fungal iterative polyketide synthase reveals strategies for maintaining biosynthetic fidelity.Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli.Bacterial Genome Mining of Enzymatic Tools for Alkyne Biosynthesis.Structural and functional analysis of two di-domain aromatase/cyclases from type II polyketide synthasesIdentifying the Minimal Enzymes Required for Biosynthesis of Epoxyketone Proteasome Inhibitors.Characterization of a fungal thioesterase having Claisen cyclase and deacetylase activities in melanin biosynthesis.Current understanding of fatty acid biosynthesis and the acyl carrier protein.A comprehensive overview on genomically directed assembly of aromatic polyketides and macrolide lactones using fungal megasynthases.Synthetic biological approaches to natural product biosynthesis.The role of transcription in heterologous expression of polyketides in bacterial hosts.Metabolic engineering of strains: from industrial-scale to lab-scale chemical production.Engineering biological systems toward a sustainable bioeconomy.Comparative characterization of fungal anthracenone and naphthacenedione biosynthetic pathways reveals an α-hydroxylation-dependent Claisen-like cyclization catalyzed by a dimanganese thioesterase.Systematic domain swaps of iterative, nonreducing polyketide synthases provide a mechanistic understanding and rationale for catalytic reprogramming.Engineering microbial cells for the biosynthesis of natural compounds of pharmaceutical significance.Navigating the fungal polyketide chemical space: from genes to molecules.Indole generates quiescent and metabolically active Escherichia coli cultures.De novo biosynthesis of terminal alkyne-labeled natural products.Phenalenone Polyketide Cyclization Catalyzed by Fungal Polyketide Synthase and Flavin-Dependent Monooxygenase.Prediction of inter domain interactions in modular polyketide synthases by docking and correlated mutation analysis.Genetic Mapping and Biochemical Basis of Yellow Feather Pigmentation in Budgerigars.Synthesis of C-Glucosylated Octaketide Anthraquinones in Nicotiana benthamiana by Using a Multispecies-Based Biosynthetic Pathway.Effects of exogenous nutrients on polyketide biosynthesis in Escherichia coli.Applications of CRISPR/Cas System to Bacterial Metabolic Engineering.Self-resistance guided genome mining uncovers new topoisomerase inhibitors from myxobacteria.Huanglongmycin A-C, Cytotoxic Polyketides Biosynthesized by a Putative Type II Polyketide Synthase From Streptomyces sp. CB09001.
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Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on 15 December 2008
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.
@en
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.
@nl
type
label
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.
@en
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.
@nl
prefLabel
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.
@en
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.
@nl
P2093
P2860
P356
P1476
Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.
@en
P2093
P2860
P304
20683-20688
P356
10.1073/PNAS.0809084105
P407
P577
2008-12-15T00:00:00Z