Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity
about
Structural basis of hereditary coproporphyria.Rationale for Bcl-xL/Bad peptide complex formation from structure, mutagenesis, and biophysical studiesA General Strategy for Targeting Drugs to BoneBinding-site assessment by virtual fragment screeningPSD-95 is a negative regulator of the tyrosine kinase Src in the NMDA receptor complexA geometry force field which converts low-resolution X-ray models to structures with properties found at ultra high resolutionSpecificity and affinity motifs for Grb2 SH2-ligand interactionsDevelopment of inhibitors for protein tyrosine kinases.Src inhibitors in the treatment of metastatic bone disease: rationale and clinical dataSrc inhibitors: genomics to therapeutics.Small molecule tyrosine kinase inhibitors: clinical development of anticancer agents.Novel therapies for osteoporosis.SH2 Ligand-Like Effects of Second Cytosolic Domain of Na/K-ATPase α1 Subunit on Src Kinase.Identification of initial leads directed at the calmodulin-binding region on the Src-SH2 domain that exhibit anti-proliferation activity against pancreatic cancerMultiple quantitative trait loci for cortical and trabecular bone regulation map to mid-distal mouse chromosome 4 that shares linkage homology to human chromosome 1p36'Magic bullets' for bone diseases: progress in rational design of bone-seeking medicinal agents.Conformationally constrained peptidomimetic inhibitors of signal transducer and activator of transcription. 3: Evaluation and molecular modeling.Synthesis and evaluation of phosphopeptides containing iminodiacetate groups as binding ligands of the Src SH2 domain.Insights into structure and function of SHIP2-SH2: homology modeling, docking, and molecular dynamics study.Ubiquitin fragments: their known biological activities and putative roles.Structure-activity relationship studies to probe the phosphoprotein binding site on the carboxy terminal domains of the breast cancer susceptibility gene 1.An in vitro assay to measure targeted drug delivery to bone mineral.Hierarchy of simulation models in predicting molecular recognition mechanisms from the binding energy landscapes: structural analysis of the peptide complexes with SH2 domains.Structure-based design of novel nonpeptide inhibitors of the Src SH2 domain:phosphotyrosine mimetics exploiting multifunctional group replacement chemistry.The osteoclast: a potential therapeutic target of bone and joint destruction in rheumatoid arthritis.Synthesis of the Src SH2 domain and its application in bioassays for mirror-image screening
P2860
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P2860
Structure-based design of an osteoclast-selective, nonpeptide src homology 2 inhibitor with in vivo antiresorptive activity
description
2000 nî lūn-bûn
@nan
2000 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
Structure-based design of an o ...... n vivo antiresorptive activity
@ast
Structure-based design of an o ...... n vivo antiresorptive activity
@en
Structure-based design of an o ...... n vivo antiresorptive activity
@nl
type
label
Structure-based design of an o ...... n vivo antiresorptive activity
@ast
Structure-based design of an o ...... n vivo antiresorptive activity
@en
Structure-based design of an o ...... n vivo antiresorptive activity
@nl
prefLabel
Structure-based design of an o ...... n vivo antiresorptive activity
@ast
Structure-based design of an o ...... n vivo antiresorptive activity
@en
Structure-based design of an o ...... n vivo antiresorptive activity
@nl
P2093
P2860
P356
P1476
Structure-based design of an o ...... n vivo antiresorptive activity
@en
P2093
C Bartlett
C Haraldson
D Dalgarno
F Cerasoli
J Iuliucci
K Stebbins
P2860
P304
P356
10.1073/PNAS.97.17.9373
P407
P577
2000-08-15T00:00:00Z