Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
about
Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length constructCrystal structure of phosphodiesterase 9 shows orientation variation of inhibitor 3-isobutyl-1-methylxanthine bindingChemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4)In Search of Enzymes with a Role in 3', 5'-Cyclic Guanosine Monophosphate Metabolism in PlantsCrystal structures of phosphodiesterases 4 and 5 in complex with inhibitor 3-isobutyl-1-methylxanthine suggest a conformation determinant of inhibitor selectivityStructural basis for the catalytic mechanism of human phosphodiesterase 9Identification of cancer-cytotoxic modulators of PDE3A by predictive chemogenomics.Scanning peptide array analyses identify overlapping binding sites for the signalling scaffold proteins, beta-arrestin and RACK1, in cAMP-specific phosphodiesterase PDE4D5.Multiple elements jointly determine inhibitor selectivity of cyclic nucleotide phosphodiesterases 4 and 7.Hesperetin-5,7,3'-O-triacetate suppresses airway hyperresponsiveness in ovalbumin-sensitized and challenged mice without reversing xylazine/ketamine-induced anesthesia in normal mice.Exploration and optimization of substituted triazolothiadiazines and triazolopyridazines as PDE4 inhibitorsMicrowave-assisted synthesis of potent PDE7 inhibitors containing a thienopyrimidin-4-amine scaffold.Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness.S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness.Characterization of a catalytic ligand bridging metal ions in phosphodiesterases 4 and 5 by molecular dynamics simulations and hybrid quantum mechanical/molecular mechanical calculations.PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationPhosphodiesterase-4 (PDE4) molecular pharmacology and Alzheimer's diseaseEngineered stabilization and structural analysis of the autoinhibited conformation of PDE4Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domainsHesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio.Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced AnesthesiaImplications of PDE4 structure on inhibitor selectivity across PDE families.Hesperidin-3'-o-methylether is more potent than hesperidin in phosphodiesterase inhibition and suppression of ovalbumin-induced airway hyperresponsiveness.Identification of a potent new chemotype for the selective inhibition of PDE4Enantiomer discrimination illustrated by the high resolution crystal structures of type 4 phosphodiesteraseEvaluation of PDE4 inhibition for COPD.Further Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics.Temporal and spatial regulation of cAMP signaling in disease: role of cyclic nucleotide phosphodiesterases.Phosphodiesterase-5 Gln817 is critical for cGMP, vardenafil, or sildenafil affinity: its orientation impacts cGMP but not cAMP affinity.Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase geneThe PDE4 cAMP-Specific Phosphodiesterases: Targets for Drugs with Antidepressant and Memory-Enhancing Action.
P2860
Q24336151-48E8CE40-6AEB-459B-9A1D-696FF14496E4Q24562006-95CAF76E-486B-4984-B586-D7BC698AC899Q24634179-D157BC2A-B933-439E-9F3D-1E652C7BEC7AQ26747346-4CF71FE2-4537-4CF9-9A3E-3754F3635D99Q27642760-D6552DC6-F4B5-4415-9877-1189FD8E7722Q27651858-EE2657CC-FA64-4783-90FE-B275D806215FQ30381467-9A65796E-757C-4288-9303-4E46CEF31421Q33243131-819011F2-95D5-458F-BDD7-F2C86DAEFDFBQ33341310-9EBE27E2-AA0F-4749-911B-32893DF32FE6Q33743617-AB2790A6-BAB0-4F18-B3C8-426D64C49197Q33853315-8814FA84-BD1C-434C-B378-BC9D07685C17Q34420467-5DBCCCEE-C62C-4C69-9662-12D5C308559FQ34706585-3D836D67-C850-4E6A-95B3-8BA045EDDC05Q34981983-3D877494-DE4D-4129-BE5A-26DD6A9D6471Q34984650-CE4355F5-6D0B-4182-B455-5A912D8A3CD4Q35005680-7EBD49CA-900C-47C8-AF77-29973335BE50Q35065003-3640AD99-836F-4674-BDB0-81A38BF2142FQ35229437-41AADE41-5CDA-4049-A964-542CB404321EQ35535258-FBAE1D7C-C5B2-4594-903C-1A0EA8447FDFQ35576638-2D685778-9BD6-4127-81C8-CA20784975F4Q35792013-B5338C2A-2A0C-4904-8A96-D04CCB76D34BQ35821270-964BFC08-E214-4CA9-AB0A-6A5BE973DDA6Q36311412-E0DEB59F-FB89-426E-BBC5-C0A87CA5A9EAQ36499703-8320BDCA-06A5-46C2-A635-C5A0F278DBBAQ36855547-38256560-D710-4120-BFD7-A590DF889B4EQ37017332-E02E1510-8298-417D-8C55-79D408697436Q37391836-6065960A-583C-4B59-A60E-CA39D55A1596Q38205932-B2380C60-DD85-46D5-B3A0-02B0F6029127Q38511520-AC610ECC-B37F-4CF2-B9B5-BA2D74146BA9Q40577866-90ED1413-1A58-4B9B-AEFC-19893FBA0E03Q47732733-68827692-6331-44B1-9CF8-104A4C63C17F
P2860
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
description
2002 nî lūn-bûn
@nan
2002 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
@ast
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
@en
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
@nl
type
label
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
@ast
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
@en
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
@nl
prefLabel
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
@ast
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
@en
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
@nl
P2093
P2860
P3181
P1433
P1476
Crystal structure of phosphodiesterase 4D and inhibitor complex(1)
@en
P2093
Hayyoung Lee
Jie Oh Lee
Joseph Markowitz
Mi Eun Lee
P2860
P3181
P356
10.1016/S0014-5793(02)03396-3
P407
P577
2002-10-23T00:00:00Z