about
The therapeutic profile of rolipram, PDE target and mechanism of action as a neuroprotectant following spinal cord injuryCyclic AMP-dependent transcriptional up-regulation of phosphodiesterase 4D5 in human airway smooth muscle cells. Identification and characterization of a novel PDE4D5 promoterMolecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoformPer-Arnt-Sim domain-dependent association of cAMP-phosphodiesterase 8A1 with IkappaB proteinsPDE4 inhibitors as potential therapeutic agents in the treatment of COPD-focus on roflumilastPhosphodiesterase genes are associated with susceptibility to major depression and antidepressant treatment responseThe effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthmaCardiac cAMP: production, hydrolysis, modulation and detectionPdeH, a high-affinity cAMP phosphodiesterase, is a key regulator of asexual and pathogenic differentiation in Magnaporthe oryzaeCrystal structure of phosphodiesterase 4D and inhibitor complex(1)In vitro PKA phosphorylation-mediated human PDE4A4 activationHuman PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary changeA new model of Pde4d deficiency: genetic knock-down of PDE4D enzyme in rats produces an antidepressant phenotype without spatial cognitive effects.A biphasic and brain-region selective down-regulation of cyclic adenosine monophosphate concentrations supports object recognition in the ratbeta-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates beta-adrenoceptor switching from Gs to GiEnhanced expression of ADCY1 underlies aberrant neuronal signalling and behaviour in a syndromic autism model.PDE4 as a target in preterm labourUbiquitous expression of phosphodiesterase 7A in human proinflammatory and immune cells.Kinetic analysis in human brain of [11C](R)-rolipram, a positron emission tomographic radioligand to image phosphodiesterase 4: a retest study and use of an image-derived input function.Zaprinast, a well-known cyclic guanosine monophosphate-specific phosphodiesterase inhibitor, is an agonist for GPR35.PDE4D and PDE4B function in distinct subcellular compartments in mouse embryonic fibroblastsPDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalizationLong PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1)Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells.Role of PDE4 in superoxide anion generation through p44/42MAPK regulation: a cAMP and a PKA-independent mechanism.Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domainsEffect of rolipram, a phosphodiesterase enzyme type-4 inhibitor, on γ-amino butyric acid content of the frontal cortex in mice exposed to chronic mild stress.Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract.Validation of PDE9A Gene Identified in GWAS Showing Strong Association with Milk Production Traits in Chinese Holstein.Cyclic nucleotide phosphodiesterases as targets for treatment of haematological malignancies.Phosphodiesterase inhibitors.Roflumilast: a phosphodiesterase-4 inhibitor for the treatment of respiratory disease.Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancersRNA interference-mediated phosphodiesterase 4D splice variants knock-down in the prefrontal cortex produces antidepressant-like and cognition-enhancing effects.Whole-body biodistribution and radiation dosimetry in monkeys and humans of the phosphodiesterase 4 radioligand [(11)C](R)-rolipram: comparison of two-dimensional planar, bisected and quadrisected image analysesThe cyclic AMP phenotype of fragile X and autismRole of phosphodiesterase 5 in synaptic plasticity and memoryFurther Insights in the Binding Mode of Selective Inhibitors to Human PDE4D Enzyme Combining Docking and Molecular Dynamics.Clinical and molecular genetics of the phosphodiesterases (PDEs).PDE4: a novel target in the treatment of chronic obstructive pulmonary disease.
P2860
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P2860
description
2001 nî lūn-bûn
@nan
2001 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
PDE4 cAMP-specific phosphodiesterases.
@ast
PDE4 cAMP-specific phosphodiesterases.
@en
PDE4 cAMP-specific phosphodiesterases.
@nl
type
label
PDE4 cAMP-specific phosphodiesterases.
@ast
PDE4 cAMP-specific phosphodiesterases.
@en
PDE4 cAMP-specific phosphodiesterases.
@nl
prefLabel
PDE4 cAMP-specific phosphodiesterases.
@ast
PDE4 cAMP-specific phosphodiesterases.
@en
PDE4 cAMP-specific phosphodiesterases.
@nl
P1476
PDE4 cAMP-specific phosphodiesterases.
@en
P2093
Houslay MD
P304
P356
10.1016/S0079-6603(01)69049-4
P577
2001-01-01T00:00:00Z