Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide
about
DYRK1A and DYRK3 promote cell survival through phosphorylation and activation of SIRT1Crystal structures of human SIRT3 displaying substrate-induced conformational changesStructure-function analysis of the yeast NAD+-dependent tRNA 2'-phosphotransferase Tpt1Structural basis for nicotinamide cleavage and ADP-ribose transfer by NAD(+)-dependent Sir2 histone/protein deacetylasesChromatin affinity-precipitation using a small metabolic molecule: its application to analysis of O-acetyl-ADP-riboseNuclear ADP-ribosylation reactions in mammalian cells: where are we today and where are we going?Structural basis for sirtuin activity and inhibitionSirtuins in epigenetic regulationStructural Basis for Nicotinamide Inhibition and Base Exchange in Sir2 EnzymesStructural Insights into Intermediate Steps in the Sir2 Deacetylation ReactionStructure of Sir2Tm bound to a propionylated peptideStructural basis for allosteric stimulation of Sir2 activity by Sir4 bindingEx-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanismStructural and Functional Analysis of Human SIRT1Domain structure and protein interactions of the silent information regulator Sir3 revealed by screening a nested deletion library of protein fragments.Budding yeast silencing complexes and regulation of Sir2 activity by protein-protein interactions.In Bacillus subtilis, the sirtuin protein deacetylase, encoded by the srtN gene (formerly yhdZ), and functions encoded by the acuABC genes control the activity of acetyl coenzyme A synthetaseInsights into Lysine Deacetylation of Natively Folded Substrate Proteins by Sirtuins.Large-scale reverse docking profiles and their applications.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesComparative genomics of the FtsK-HerA superfamily of pumping ATPases: implications for the origins of chromosome segregation, cell division and viral capsid packagingSIRT1 top 40 hits: use of one-bead, one-compound acetyl-peptide libraries and quantum dots to probe deacetylase specificity.SIRT3 substrate specificity determined by peptide arrays and machine learning.Design and synthesis of compounds that extend yeast replicative lifespan.Structure and biochemical functions of SIRT6.Insight into the Mechanism of Intramolecular Inhibition of the Catalytic Activity of Sirtuin 2 (SIRT2).Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrolSwapping the gene-specific and regional silencing specificities of the Hst1 and Sir2 histone deacetylases.Using mitochondrial sirtuins as drug targets: disease implications and available compounds.Sir2 protein deacetylases: evidence for chemical intermediates and functions of a conserved histidine.A yeast sir2 mutant temperature sensitive for silencing.Computational studies on the histone deacetylases and the design of selective histone deacetylase inhibitors.Structural basis for sirtuin function: what we know and what we don't.Sirtuin/Sir2 phylogeny, evolutionary considerations and structural conservation.Modulations of SIR-nucleosome interactions of reconstructed yeast silent pre-heterochromatin by O-acetyl-ADP-ribose and magnesium.The discovery of a highly selective 5,6,7,8-tetrahydrobenzo[4,5]thieno[2,3-d]pyrimidin-4(3H)-one SIRT2 inhibitor that is neuroprotective in an in vitro Parkinson's disease model.The Current State of NAD(+) -Dependent Histone Deacetylases (Sirtuins) as Novel Therapeutic Targets.Bypassing the catalytic activity of SIR2 for SIR protein spreading in Saccharomyces cerevisiae.Combining mass spectrometry and peptide arrays to profile the specificities of histone deacetylases.Quantification of endogenous sirtuin metabolite O-acetyl-ADP-ribose.
P2860
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P2860
Structure of the yeast Hst2 protein deacetylase in ternary complex with 2'-O-acetyl ADP ribose and histone peptide
description
2003 nî lūn-bûn
@nan
2003 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Structure of the yeast Hst2 pr ...... ADP ribose and histone peptide
@ast
Structure of the yeast Hst2 pr ...... ADP ribose and histone peptide
@en
Structure of the yeast Hst2 pr ...... ADP ribose and histone peptide
@nl
type
label
Structure of the yeast Hst2 pr ...... ADP ribose and histone peptide
@ast
Structure of the yeast Hst2 pr ...... ADP ribose and histone peptide
@en
Structure of the yeast Hst2 pr ...... ADP ribose and histone peptide
@nl
prefLabel
Structure of the yeast Hst2 pr ...... ADP ribose and histone peptide
@ast
Structure of the yeast Hst2 pr ...... ADP ribose and histone peptide
@en
Structure of the yeast Hst2 pr ...... ADP ribose and histone peptide
@nl
P1433
P1476
Structure of the yeast Hst2 pr ...... ADP ribose and histone peptide
@en
P2093
Kehao Zhao
Xiaomei Chai
P304
P356
10.1016/J.STR.2003.09.016
P577
2003-11-01T00:00:00Z