Crystal structures of human SIRT3 displaying substrate-induced conformational changes
about
Structural basis for sirtuin activity and inhibitionSirtuin 1 and sirtuin 3: physiological modulators of metabolismSirtuins in epigenetic regulationStructure of Sir2Tm bound to a propionylated peptideThe Bicyclic Intermediate Structure Provides Insights into the Desuccinylation Mechanism of Human Sirtuin 5 (SIRT5)A Molecular Mechanism for Direct Sirtuin Activation by ResveratrolEx-527 inhibits Sirtuins by exploiting their unique NAD+-dependent deacetylation mechanismStructural and Functional Analysis of Human SIRT1Structures of human sirtuin 3 complexes with ADP-ribose and with carba-NAD+ and SRT1720: binding details and inhibition mechanismMammalian sirtuins: biological insights and disease relevanceSelective Sirt2 inhibition by ligand-induced rearrangement of the active site.An acetylome peptide microarray reveals specificities and deacetylation substrates for all human sirtuin isoforms.Role of the Substrate Specificity-Defining Residues of Human SIRT5 in Modulating the Structural Stability and Inhibitory Features of the Enzyme.Modulation of epigenetic targets for anticancer therapy: clinicopathological relevance, structural data and drug discovery perspectivesPeptides and Pseudopeptides as SIRT6 Deacetylation Inhibitors.SIRT3 substrate specificity determined by peptide arrays and machine learning.Sirtuin regulation of mitochondria: energy production, apoptosis, and signaling.Compartmentation of NAD+-dependent signalling.Structure-based development of novel sirtuin inhibitors.Sirt5 deacylation activities show differential sensitivities to nicotinamide inhibition.Beyond histone and deacetylase: an overview of cytoplasmic histone deacetylases and their nonhistone substratesStructure and biochemical functions of SIRT6.4-Hydroxynonenal inhibits SIRT3 via thiol-specific modification.Mechanism-based affinity capture of sirtuinsA mechanism-based potent sirtuin inhibitor containing Nε-thiocarbamoyl-lysine (TuAcK)Identification of 'erasers' for lysine crotonylated histone marks using a chemical proteomics approach.Propofol inhibits SIRT2 deacetylase through a conformation-specific, allosteric site.Mechanism of inhibition of the human sirtuin enzyme SIRT3 by nicotinamide: computational and experimental studiesThe human sirtuin family: evolutionary divergences and functions.Structural basis for allosteric, substrate-dependent stimulation of SIRT1 activity by resveratrolUsing mitochondrial sirtuins as drug targets: disease implications and available compounds.The sirtuins in the pathogenesis of cancer.SIRT6 Is a Positive Regulator of Aldose Reductase Expression in U937 and HeLa cells under Osmotic Stress: In Vitro and In Silico Insights.Ten years of NAD-dependent SIR2 family deacetylases: implications for metabolic diseases.SIRT3 Mediates the Antioxidant Effect of Hydrogen Sulfide in Endothelial Cells.Investigating the Sensitivity of NAD+-dependent Sirtuin Deacylation Activities to NADHAnaplasma phagocytophilum increases the levels of histone modifying enzymes to inhibit cell apoptosis and facilitate pathogen infection in the tick vector Ixodes scapularis.Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.An Artificial Reaction Promoter Modulates Mitochondrial Functions via Chemically Promoting Protein Acetylation.The emerging and diverse roles of sirtuins in cancer: a clinical perspective.
P2860
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P2860
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
description
2009 nî lūn-bûn
@nan
2009 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@ast
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@en
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@en-gb
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@nl
type
label
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@ast
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@en
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@en-gb
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@nl
altLabel
Crystal Structures of Human SIRT3 Displaying Substrate-induced Conformational Changes
@en
prefLabel
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@ast
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@en
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@en-gb
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@nl
P2093
P2860
P921
P3181
P356
P1476
Crystal structures of human SIRT3 displaying substrate-induced conformational changes
@en
P2093
Christoph H Westphal
Jean E Bemis
Jianhua Cai
Jill C Milne
Michael R Jirousek
Robert B Perni
P2860
P304
P3181
P356
10.1074/JBC.M109.014928
P407
P577
2009-09-04T00:00:00Z