Crystal structure and mechanism of a bacterial fluorinating enzyme
about
Discovery and characterization of a marine bacterial SAM-dependent chlorinaseWhat's new in enzymatic halogenationsNatural history of S-adenosylmethionine-binding proteinsInsights into enzymatic halogenation from computational studiesMechanism of Enzymatic Fluorination in Streptomyces c attleyaMechanistic Insights into Water Activation in SAM Hydroxide Adenosyltransferase (duf-62)Halomethane Biosynthesis: Structure of a SAM-Dependent Halide Methyltransferase from Arabidopsis thalianaStructural Basis for the Activity and Substrate Specificity of Fluoroacetyl-CoA Thioesterase FlKStructural and Biochemical Studies of a Fluoroacetyl-CoA-Specific Thioesterase Reveal a Molecular Basis for Fluorine SelectivityMapping the Reaction Coordinates of Enzymatic DefluorinationCatalysis for fluorination and trifluoromethylationIdentification of fluorinases from Streptomyces sp MA37, Norcardia brasiliensis, and Actinoplanes sp N902-109 by genome miningDirected Evolution of a Fluorinase for Improved Fluorination Efficiency with a Non-native SubstrateLate-Stage Fluorination: From Fundamentals to ApplicationSynthetic biology approaches to fluorinated polyketidesStructure-guided comparative analysis of proteins: principles, tools, and applications for predicting function.Expanding the fluorine chemistry of living systems using engineered polyketide synthase pathways.Salinosporamide natural products: Potent 20 S proteasome inhibitors as promising cancer chemotherapeutics.Insights from the sea: structural biology of marine polyketide synthasesNatural and engineered biosynthesis of fluorinated natural products.Tryptophan 7-halogenase (PrnA) structure suggests a mechanism for regioselective chlorination.The marine actinomycete genus Salinispora: a model organism for secondary metabolite discoveryThe fluorinase from Streptomyces cattleya is also a chlorinaseA sea of biosynthesis: marine natural products meet the molecular age.Independent Evolution of Six Families of Halogenating Enzymes.A metagenomic-based survey of microbial (de)halogenation potential in a German forest soil.Chlorination diversifies Cimicifuga racemosa triterpene glycosides.S-Adenosyl-L-methionine hydrolase (adenosine-forming), a conserved bacterial and archaeal protein related to SAM-dependent halogenases.Structural perspective on enzymatic halogenation.Biosynthesis of the salinosporamide A polyketide synthase substrate chloroethylmalonyl-coenzyme A from S-adenosyl-L-methionine.Biosynthesis of polyketide synthase extender units.Marine-derived metabolites of S-adenosylmethionine as templates for new anti-infectives.Structural insights into radical generation by the radical SAM superfamily.Fluorinase: a tool for the synthesis of ¹⁸F-labeled sugars and nucleosides for PET.Introduction of fluorine and fluorine-containing functional groups.Functional diversity of organic molecule enzyme cofactors.Late-stage formation of carbon-fluorine bonds.Fluoro amino acids: a rarity in nature, yet a prospect for protein engineering.Fluoroacetate in plants - a review of its distribution, toxicity to livestock and microbial detoxification.Enzymatic Halogenation and Dehalogenation Reactions: Pervasive and Mechanistically Diverse.
P2860
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P2860
Crystal structure and mechanism of a bacterial fluorinating enzyme
description
2004 nî lūn-bûn
@nan
2004 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystal structure and mechanism of a bacterial fluorinating enzyme
@ast
Crystal structure and mechanism of a bacterial fluorinating enzyme
@en
Crystal structure and mechanism of a bacterial fluorinating enzyme
@nl
type
label
Crystal structure and mechanism of a bacterial fluorinating enzyme
@ast
Crystal structure and mechanism of a bacterial fluorinating enzyme
@en
Crystal structure and mechanism of a bacterial fluorinating enzyme
@nl
prefLabel
Crystal structure and mechanism of a bacterial fluorinating enzyme
@ast
Crystal structure and mechanism of a bacterial fluorinating enzyme
@en
Crystal structure and mechanism of a bacterial fluorinating enzyme
@nl
P2093
P3181
P356
P1433
P1476
Crystal structure and mechanism of a bacterial fluorinating enzyme
@en
P2093
Changjiang Dong
Christoph Schaffrath
David O'Hagan
Fanglu Huang
Jonathan B Spencer
P2888
P3181
P356
10.1038/NATURE02280
P407
P577
2004-02-05T00:00:00Z
P6179
1025785517