Increased folding stability of TEM-1 beta-lactamase by in vitro selection
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Biophysical characterization of mutants ofBacillus subtilislipase evolved for thermostability: Factors contributing to increased activity retentionNetwork models of TEM β-lactamase mutations coevolving under antibiotic selection show modular structure and anticipate evolutionary trajectoriesIdentification and characterization of beta-lactamase inhibitor protein-II (BLIP-II) interactions with beta-lactamases using phage display.Enzyme Efficiency but Not Thermostability Drives Cefotaxime Resistance Evolution in TEM-1 β-Lactamase.Initial mutations direct alternative pathways of protein evolutionDeep sequencing of systematic combinatorial libraries reveals β-lactamase sequence constraints at high resolution.Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.Multiple global suppressors of protein stability defects facilitate the evolution of extended-spectrum TEM β-lactamases.Identification of TEM-135 β-lactamase in Neisseria gonorrhoeae strains carrying African and Toronto plasmids in ArgentinaMutational studies on resurrected ancestral proteins reveal conservation of site-specific amino acid preferences throughout evolutionary history.Discovery of multiple hidden allosteric sites by combining Markov state models and experimentsVirulence factors and TEM-type β-lactamases produced by two isolates of an epidemic Klebsiella pneumoniae strain.Novel Computational Protocols for Functionally Classifying and Characterising Serine Beta-Lactamases.Mistranslation drives the evolution of robustness in TEM-1 β-lactamase.Low-stringency selection of TEM1 for BLIP shows interface plasticity and selection for faster binders.Resistance of Undisturbed Soil Microbiomes to Ceftriaxone Indicates Extended Spectrum β-Lactamase ActivityDesign of protein switches based on an ensemble model of allosteryRole of Non-Active-Site Residue Trp-93 in the Function and Stability of New Delhi Metallo-β-Lactamase 1.Antibiotics as selectors and accelerators of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases worldSHV-129: A Gateway to Global Suppressors in the SHV β-Lactamase Family?Capturing the mutational landscape of the beta-lactamase TEM-1.Potential role of phenotypic mutations in the evolution of protein expression and stability.Natural evolution of TEM-1 β-lactamase: experimental reconstruction and clinical relevance.Lessons about protein stability from in vitro selections.Modulating protein stability - directed evolution strategies for improved protein function.Increasing protein stability: importance of DeltaC(p) and the denatured state.Probing protein stability and proteolytic resistance by loop scanning: a comprehensive mutational analysis.Molecular Determinants for Protein Stabilization by Insertional Fusion to a Thermophilic Host Protein.Prediction of New Stabilizing Mutations Based on Mechanistic Insights from Markov State Models.Evolving Bacterial Fitness with an Expanded Genetic Code.Variation in Mutational Robustness between Different Proteins and the Predictability of Fitness Effects.Adaptive benefits from small mutation supplies in an antibiotic resistance enzyme.Protein and Protease Sensing by Allosteric Derepression.Targeting functional motifs of a protein family.On the Potential Origins of the High Stability of Reconstructed Ancestral Proteins.Structural and Mechanistic Basis for Extended-Spectrum Drug-Resistance Mutations in Altering the Specificity of TEM, CTX-M, and KPC β-lactamases.Identification of Novel Neisseria Gonorrhoeae Lineages Harbouring Resistance Plasmids in Coastal Kenya.TAT hitchhiker selection expanded to folding helpers, multimeric interactions and combinations with protein fragment complementation.Engineering allosteric regulation into the hinge region of a circularly permuted TEM-1 beta-lactamase
P2860
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P2860
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
description
2008 nî lūn-bûn
@nan
2008 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
@ast
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
@en
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
@nl
type
label
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
@ast
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
@en
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
@nl
prefLabel
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
@ast
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
@en
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
@nl
P3181
P1476
Increased folding stability of TEM-1 beta-lactamase by in vitro selection
@en
P2093
Insa Kather
Roman P Jakob
P304
P3181
P356
10.1016/J.JMB.2008.07.082
P407
P577
2008-10-31T00:00:00Z