Structure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate Reductase
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Probing the Active Site ofCandida glabrataDihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New InhibitorsCrystal Structures of Wild-type and Mutant Methicillin-resistant Staphylococcus aureus Dihydrofolate Reductase Reveal an Alternate Conformation of NADPH That May Be Linked to Trimethoprim ResistanceThe Solution Structure of Bacillus anthracis Dihydrofolate Reductase Yields Insight into the Analysis of Structure−Activity Relationships for Novel InhibitorsTowards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductaseCrystal Structures of Candida albicans Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal the Flexibility of Active Site Loop Residues Critical for Ligand Potency and SelectivityStructural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among speciesElucidating Features That Drive the Design of Selective Antifolates Using Crystal Structures of Human Dihydrofolate ReductasePropargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrataReverse Chemical Genetics: Comprehensive Fitness Profiling Reveals the Spectrum of Drug Target InteractionsAntifolate agents: a patent review (2006 - 2010).Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.Acetylenic linkers in lead compounds: a study of the stability of the propargyl-linked antifolates.Towards new antifolates targeting eukaryotic opportunistic infectionsDihydrofolate reductase as a therapeutic target for infectious diseases: opportunities and challenges.Antifolate agents: a patent review (2010 - 2013).New techniques in antibiotic discovery and resistance: Raman spectroscopy.Strategies in the discovery of novel antifungal scaffolds.2,4-Diamino-5-(2'-arylpropargyl)pyrimidine derivatives as new nonclassical antifolates for human dihydrofolate reductase inhibition.In vitro biological activity and structural analysis of 2,4-diamino-5-(2'-arylpropargyl)pyrimidine inhibitors of Candida albicans.Structural analysis of dihydrofolate reductases enables rationalization of antifolate binding affinities and suggests repurposing possibilities.Scoring ensembles of docked protein:ligand interactions for virtual lead optimization.
P2860
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P2860
Structure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate Reductase
description
2008 nî lūn-bûn
@nan
2008 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structure-Guided Development o ...... abrata Dihydrofolate Reductase
@ast
Structure-Guided Development o ...... abrata Dihydrofolate Reductase
@en
Structure-Guided Development o ...... abrata Dihydrofolate Reductase
@nl
type
label
Structure-Guided Development o ...... abrata Dihydrofolate Reductase
@ast
Structure-Guided Development o ...... abrata Dihydrofolate Reductase
@en
Structure-Guided Development o ...... abrata Dihydrofolate Reductase
@nl
prefLabel
Structure-Guided Development o ...... abrata Dihydrofolate Reductase
@ast
Structure-Guided Development o ...... abrata Dihydrofolate Reductase
@en
Structure-Guided Development o ...... abrata Dihydrofolate Reductase
@nl
P2093
P2860
P921
P3181
P1476
Structure-guided development o ...... abrata dihydrofolate reductase
@en
P2093
Adrienne E Smith
Amy C Anderson
David B Bolstad
Jieying Liu
Nigel D Priestley
P2860
P304
P3181
P356
10.1016/J.CHEMBIOL.2008.07.013
P577
2008-09-01T00:00:00Z