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Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

http://www.wikidata.org/entity/Q27681900

about

Propargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosis Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.Antivitamins for Medicinal Applications.Strategies in the discovery of novel antifungal scaffolds.Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks.Synthesis, bioactivity, molecular docking and POM analyses of novel substituted thieno[2,3-b]thiophenes and related congeners.Characterization of trimethoprim resistant E. coli dihydrofolate reductase mutants by mass spectrometry and inhibition by propargyl-linked antifolates.

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Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

http://www.wikidata.org/entity/Q27681900

description

2014 nî lūn-bûn

@nan

2014 թուականի Մարտին հրատարակուած գիտական յօդուած

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2014 թվականի մարտին հրատարակված գիտական հոդված

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2014年の論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年論文

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2014年论文

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name

Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

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Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

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Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

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type

label

Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

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Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

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Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

@nl

prefLabel

Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

@ast

Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

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Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

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Journal of Medicinal Chemistry

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Propargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrata

@en

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Adrienne E Sochia

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Amy C Anderson

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Janet L Paulsen

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Jeremy B Alverson

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Kishore Viswanathan

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Kristen M Lamb

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Michael N Lombardo

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Narendran G-Dayanandan

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Nigel D Priestley

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Santosh Keshipeddy

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P2860

Delaying the empiric treatment of candida bloodstream infection until positive blood culture results are obtained: a potential risk factor for hospital mortality

Targeted mutations of Bacillus anthracis dihydrofolate reductase condense complex structure−activity relationships

Structure-Guided Development of Efficacious Antifungal Agents Targeting Candida glabrata Dihydrofolate Reductase

Probing the Active Site ofCandida glabrataDihydrofolate Reductase with High Resolution Crystal Structures and the Synthesis of New Inhibitors

Crystal Structures of Candida albicans Dihydrofolate Reductase Bound to Propargyl-Linked Antifolates Reveal the Flexibility of Active Site Loop Residues Critical for Ligand Potency and Selectivity

Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species

Toward New Therapeutics for Skin and Soft Tissue Infections: Propargyl-Linked Antifolates Are Potent Inhibitors of MRSA and Streptococcus pyogenes

X-ray crystallographic studies of Candida albicans dihydrofolate reductase. High resolution structures of the holoenzyme and an inhibited ternary complex

Coot: model-building tools for molecular graphics

Solving structures of protein complexes by molecular replacement with Phaser

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2643-2656

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scholarly article

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3798128

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10.1021/JM401916J

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6

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57

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Dennis L Wright

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2014-03-27T00:00:00Z

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260380586

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24568657

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P921

Candida glabrata

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3983340

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