Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species
about
Elucidating Features That Drive the Design of Selective Antifolates Using Crystal Structures of Human Dihydrofolate ReductasePropargyl-Linked Antifolates are Dual Inhibitors of Candida albicans and Candida glabrataPropargyl-Linked Antifolates Are Potent Inhibitors of Drug-Sensitive and Drug-Resistant Mycobacterium tuberculosisCrystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.Antifolate agents: a patent review (2010 - 2013).Strategies in the discovery of novel antifungal scaffolds.Structural analysis of dihydrofolate reductases enables rationalization of antifolate binding affinities and suggests repurposing possibilities.Direct Substitution of Arylalkynyl Carbinols Provides Access to Diverse Terminal Acetylene Building Blocks.
P2860
Q27680000-24D33BE5-A2A5-4355-9C68-C458D9F91DB4Q27681900-91C75115-FBFC-4BEC-A832-6FD1BC99B1E8Q28553792-93E5B067-69E5-4C0B-A40F-38C3262E5760Q34597438-F3640883-3A79-4B90-AEEC-C876989B0163Q38198160-0E0891AE-88E1-4938-B573-3E4EC31631BAQ38837363-4511276F-9F9B-4CD2-A5B2-A86EB01E5708Q40075521-17CF5222-913B-4760-A53A-A134DC7FF5FAQ53543284-C5C7FC64-A1FD-457B-B0B3-39319AFA2A40
P2860
Structural analysis of the active sites of dihydrofolate reductase from two species of Candida uncovers ligand-induced conformational changes shared among species
description
2013 nî lūn-bûn
@nan
2013 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2013 թվականի մարտին հրատարակված գիտական հոդված
@hy
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
name
Structural analysis of the act ...... l changes shared among species
@ast
Structural analysis of the act ...... l changes shared among species
@en
Structural analysis of the act ...... l changes shared among species
@nl
type
label
Structural analysis of the act ...... l changes shared among species
@ast
Structural analysis of the act ...... l changes shared among species
@en
Structural analysis of the act ...... l changes shared among species
@nl
prefLabel
Structural analysis of the act ...... l changes shared among species
@ast
Structural analysis of the act ...... l changes shared among species
@en
Structural analysis of the act ...... l changes shared among species
@nl
P2093
P2860
P921
P3181
P1476
Structural analysis of the act ...... l changes shared among species
@en
P2093
Amy C Anderson
Janet L Paulsen
Kishore Viswanathan
P2860
P304
P3181
P356
10.1016/J.BMCL.2013.01.008
P407
P577
2013-01-11T00:00:00Z