The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease
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Activity, stability, and structure of metagenome-derived LC11-RNase H1, a homolog ofSulfolobus tokodaiiRNase H1Structure and characterization of RNase H3 from Aquifex aeolicusNovel complex MAD phasing and RNase H structural insights using selenium oligonucleotidesAnalysis of subunit assembly and function of the Saccharomyces cerevisiae RNase H2 complex.Lagging-strand replication shapes the mutational landscape of the genomeVariations in brain DNAMammalian RNase H2 removes ribonucleotides from DNA to maintain genome integrityTranscription-associated R-loop formation across the human FMR1 CGG-repeat regionA Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation InitiationRibonuclease H1-dependent hepatotoxicity caused by locked nucleic acid-modified gapmer antisense oligonucleotidesRole of N-terminal extension of Bacillus stearothermophilus RNase H2 and C-terminal extension of Thermotoga maritima RNase H2.Ribonucleotide incorporation by human DNA polymerase η impacts translesion synthesis and RNase H2 activity.Processing ribonucleotides incorporated during eukaryotic DNA replication.Aicardi-Goutieres syndrome: from patients to genes and beyond.Enzymatic removal of ribonucleotides from DNA is essential for mammalian genome integrity and development.Ribonuclease H2 in health and disease.Identification of small-molecule inhibitors of the ribonuclease H2 enzyme.Identification of host proteins interacting with the integrin-like A domain of Toxoplasma gondii micronemal protein MIC2 by yeast-two-hybrid screening.Reduction of hRNase H2 activity in Aicardi-Goutières syndrome cells leads to replication stress and genome instabilityFunctional consequences of the RNase H2A subunit mutations that cause Aicardi-Goutieres syndrome.Defective removal of ribonucleotides from DNA promotes systemic autoimmunity.Transcriptional responses to loss of RNase H2 in Saccharomyces cerevisiae.RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.The Balancing Act of Ribonucleotides in DNARibonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.Elucidating common structural features of human pathogenic variations using large-scale atomic-resolution protein networksSynonymous mutations in RNASEH2A create cryptic splice sites impairing RNase H2 enzyme function in Aicardi-Goutières syndrome.Rare coding variants and breast cancer risk: evaluation of susceptibility Loci identified in genome-wide association studies.Aicardi-Goutières syndrome: clues from the RNase H2 knock-out mouse.Quaternary structure is an essential component that contributes to the sophisticated allosteric regulation mechanism in a key enzyme from Mycobacterium tuberculosis.Genome-wide mapping of embedded ribonucleotides and other noncanonical nucleotides using emRiboSeq and EndoSeq.Genome integrity and disease prevention in the nervous system.Striking intrafamilial phenotypic variability in Aicardi-Goutières syndrome associated with the recurrent Asian founder mutation inRNASEH2CCRISPR screens identify genomic ribonucleotides as a source of PARP-trapping lesions
P2860
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P2860
The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease
description
2011 nî lūn-bûn
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2011 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի մարտին հրատարակված գիտական հոդված
@hy
2011年の論文
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2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
name
The Structure of the Human RNa ...... yme Function and Human Disease
@ast
The Structure of the Human RNa ...... yme Function and Human Disease
@en
The Structure of the Human RNa ...... yme Function and Human Disease
@nl
type
label
The Structure of the Human RNa ...... yme Function and Human Disease
@ast
The Structure of the Human RNa ...... yme Function and Human Disease
@en
The Structure of the Human RNa ...... yme Function and Human Disease
@nl
prefLabel
The Structure of the Human RNa ...... yme Function and Human Disease
@ast
The Structure of the Human RNa ...... yme Function and Human Disease
@en
The Structure of the Human RNa ...... yme Function and Human Disease
@nl
P2093
P2860
P3181
P356
P1476
The Structure of the Human RNa ...... yme Function and Human Disease
@en
P2093
Doryen Bubeck
E Yvonne Jones
George S Baillie
Lucien C D Gibson
Martin A M Reijns
P2860
P304
P3181
P356
10.1074/JBC.M110.177394
P407
P577
2011-03-25T00:00:00Z