RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.
about
DNA sensor cGAS-mediated immune recognitionRibonuclease L mediates the cell-lethal phenotype of double-stranded RNA editing enzyme ADAR1 deficiency in a human cell line.The E3 ubiquitin ligase RNF185 facilitates the cGAS-mediated innate immune response.Type I interferon-mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overviewLack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.The role of cGAS in innate immunity and beyond.Therapeutic potential of targeting TBK1 in autoimmune diseases and interferonopathies.Taking the STING out of TLR-driven autoimmune diseases: good, bad, or indifferent?Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.Insights from Mendelian Interferonopathies: Comparison of CANDLE, SAVI with AGS, Monogenic Lupus.Cytosolic nucleic acid sensors and innate immune regulation.Immune Diseases Associated with TREX1 and STING Dysfunction.Regulating STING in health and diseaseDNA damage-induced immune response: Micronuclei provide key platform.cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry.RIG-I-Like Receptors and Type I Interferonopathies.cGAS surveillance of micronuclei links genome instability to innate immunity.cGAS-STING do it again: pivotal role in RNase H2 genetic disease.Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.Effects of neutral salts and pH on the activity and stability of human RNase H2.Interplay between RNASEH2 and MOV10 controls LINE-1 retrotransposition.Cytosolic sensing of immuno-stimulatory DNA, the enemy within.Dynamic nucleoplasmic and nucleolar localization of mammalian RNase H1 in response to RNAP I transcriptional R-loops.Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis.Activation of the Innate Immune Receptors: Guardians of the Micro Galaxy : Activation and Functions of the Innate Immune Receptors.Delicate regulation of the cGAS-MITA-mediated innate immune response.cGAS-mediated autophagy protects the liver from ischemia/reperfusion injury independent of STING.Single Cell Gel Electrophoresis for the Detection of Genomic Ribonucleotides.Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING.The Regulation of cGAS.Prognostic Value of RNASEH2A-, CDK1-, and CD151-Related Pathway Gene Profiling for Kidney Cancers.RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.Activity of Retrotransposons in Stem Cells and Differentiated Cells
P2860
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P2860
RNase H2 catalytic core Aicardi-Goutières syndrome-related mutant invokes cGAS-STING innate immune-sensing pathway in mice.
description
2016 nî lūn-bûn
@nan
2016年の論文
@ja
2016年論文
@yue
2016年論文
@zh-hant
2016年論文
@zh-hk
2016年論文
@zh-mo
2016年論文
@zh-tw
2016年论文
@wuu
2016年论文
@zh
2016年论文
@zh-cn
name
RNase H2 catalytic core Aicard ...... mmune-sensing pathway in mice.
@ast
RNase H2 catalytic core Aicard ...... mmune-sensing pathway in mice.
@en
type
label
RNase H2 catalytic core Aicard ...... mmune-sensing pathway in mice.
@ast
RNase H2 catalytic core Aicard ...... mmune-sensing pathway in mice.
@en
prefLabel
RNase H2 catalytic core Aicard ...... mmune-sensing pathway in mice.
@ast
RNase H2 catalytic core Aicard ...... mmune-sensing pathway in mice.
@en
P2093
P2860
P356
P1476
RNase H2 catalytic core Aicard ...... immune-sensing pathway in mice
@en
P2093
Hyongi Chon
Jerrold M Ward
Kiran Sakhuja
Naushaba Hasin
Robert J Crouch
Susana M Cerritelli
Vladislav Pokatayev
P2860
P304
P356
10.1084/JEM.20151464
P407
P50
P577
2016-02-15T00:00:00Z