Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response. - Wikidata - wikimedia - TriplyDB

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

http://www.wikidata.org/entity/Q36866528

about

Type I interferon-mediated monogenic autoinflammation: The type I interferonopathies, a conceptual overview Lack of Trex1 Causes Systemic Autoimmunity despite the Presence of Antiretroviral Drugs.A prosurvival DNA damage-induced cytoplasmic interferon response is mediated by end resection factors and is limited by Trex1.The role of cGAS in innate immunity and beyond.Regulation and function of the cGAS-STING pathway of cytosolic DNA sensing.Insights from Mendelian Interferonopathies: Comparison of CANDLE, SAVI with AGS, Monogenic Lupus.cGAS-cGAMP-STING: The three musketeers of cytosolic DNA sensing and signaling.Cytosolic nucleic acid sensors and innate immune regulation.Mitochondrial DNA in innate immune responses and inflammatory pathology.Regulating STING in health and disease Genome instabilities arising from ribonucleotides in DNA.DNA damage-induced immune response: Micronuclei provide key platform.cGAMP Quantification in Virus-Infected Human Monocyte-Derived Cells by HPLC-Coupled Tandem Mass Spectrometry.Length does matter for cGAS.RIG-I-Like Receptors and Type I Interferonopathies.cGAS surveillance of micronuclei links genome instability to innate immunity.RNase H As Gene Modifier, Driver of Evolution and Antiviral Defense.cGAS-STING Activation in the Tumor Microenvironment and Its Role in Cancer Immunity.cGAS-STING do it again: pivotal role in RNase H2 genetic disease.Absence of RNase H2 triggers generation of immunogenic micronuclei removed by autophagy.Effects of neutral salts and pH on the activity and stability of human RNase H2.Cytosolic sensing of immuno-stimulatory DNA, the enemy within.Rare ADAR and RNASEH2B variants and a type I interferon signature in glioma and prostate carcinoma risk and tumorigenesis.Delicate regulation of the cGAS-MITA-mediated innate immune response.Single Cell Gel Electrophoresis for the Detection of Genomic Ribonucleotides.Pro-inflammation Associated with a Gain-of-Function Mutation (R284S) in the Innate Immune Sensor STING.RNase H2 Loss in Murine Astrocytes Results in Cellular Defects Reminiscent of Nucleic Acid-Mediated Autoinflammation.Microbial Sensing by Intestinal Myeloid Cells Controls Carcinogenesis and Epithelial Differentiation Monogenic Lupus: A Developing Paradigm of Disease

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P2860

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

http://www.wikidata.org/entity/Q36866528

description

2016 nî lūn-bûn

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2016年の論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年論文

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2016年论文

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2016年论文

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2016年论文

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name

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

@en

type

label

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

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prefLabel

Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

@en

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The EMBO Journal

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Ribonuclease H2 mutations induce a cGAS/STING-dependent innate immune response.

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P2093

Adeline Fluteau

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Ailsa Revuelta

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Björn Rabe

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Erika Abbondati

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Fiona Kilanowski

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Flora Dix

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Graeme Grimes

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Kaalak Reddy

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Karen J Mackenzie

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Laura Lettice

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P2860

Genome engineering using the CRISPR-Cas9 system

Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway

The structural and biochemical characterization of human RNase H2 complex reveals the molecular basis for substrate recognition and Aicardi-Goutières syndrome defects

Mutations involved in Aicardi-Goutières syndrome implicate SAMHD1 as regulator of the innate immune response

Trex1 prevents cell-intrinsic initiation of autoimmunity

The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease

RNase H2 roles in genome integrity revealed by unlinking its activities

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

Mutations in the gene encoding the 3'-5' DNA exonuclease TREX1 cause Aicardi-Goutières syndrome at the AGS1 locus

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself

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10.15252/EMBJ.201593339

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8

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35

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Žygimantė Tarnauskaitė

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2016-02-22T00:00:00Z

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295674893

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