Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.

Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.

Item
http://www.wikidata.org/entity/Q34264646
Eukaryotic RNases H1 act processively by interactions through the duplex RNA-binding domainCatalytic mechanism of RNA backbone cleavage by ribonuclease H from quantum mechanics/molecular mechanics simulations.Human RNase H1 is associated with protein P32 and is involved in mitochondrial pre-rRNA processingOligonucleotide-based strategies to combat polyglutamine diseases.Structural requirements at the catalytic site of the heteroduplex substrate for human RNase H1 catalysis.Synthesis, biophysical properties and biological activity of second generation antisense oligonucleotides containing chiral phosphorothioate linkages.Viable RNaseH1 knockout mice show RNaseH1 is essential for R loop processing, mitochondrial and liver functionSelective enhancement of nucleases by polyvalent DNA-functionalized gold nanoparticles.Artificial reaction coordinate "tunneling" in free-energy calculations: the catalytic reaction of RNase H.Crystal structure of A. aeolicus argonaute, a site-specific DNA-guided endoribonuclease, provides insights into RISC-mediated mRNA cleavageEffects of local mRNA structure on posttranscriptional gene silencing.Molecular Mechanisms of Antisense Oligonucleotides.The N-terminal hybrid binding domain of RNase HI from Thermotoga maritima is important for substrate binding and Mg2+-dependent activity.An alternative advantageous protocol for efficient synthesis of phosphorothioate oligonucleotides utilizing phenylacetyl disulfide (PADS).Identification of the gene encoding a type 1 RNase H with an N-terminal double-stranded RNA binding domain from a psychrotrophic bacterium.
P2860

Human RNase H1 uses one tryptophan and two lysines to position the enzyme at the 3'-DNA/5'-RNA terminus of the heteroduplex substrate.

Item
http://www.wikidata.org/entity/Q34264646
description
2003 nî lūn-bûn
@nan
2003 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2003 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
name
Human RNase H1 uses one trypto ...... of the heteroduplex substrate.
@ast
Human RNase H1 uses one trypto ...... of the heteroduplex substrate.
@en
Human RNase H1 uses one trypto ...... of the heteroduplex substrate.
@nl
type
label
Human RNase H1 uses one trypto ...... of the heteroduplex substrate.
@ast
Human RNase H1 uses one trypto ...... of the heteroduplex substrate.
@en
Human RNase H1 uses one trypto ...... of the heteroduplex substrate.
@nl
prefLabel
Human RNase H1 uses one trypto ...... of the heteroduplex substrate.
@ast
Human RNase H1 uses one trypto ...... of the heteroduplex substrate.
@en
Human RNase H1 uses one trypto ...... of the heteroduplex substrate.
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698
P356
P1433
P1476
Human RNase H1 uses one trypto ...... of the heteroduplex substrate.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P698