The catalytic domain of human immunodeficiency virus integrase: ordered active site in the F185H mutant
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Crystal structure of the HIV-1 integrase catalytic core and C-terminal domains: A model for viral DNA bindingCrystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding siteBinding of different divalent cations to the active site of avian sarcoma virus integrase and their effects on enzymatic activityStructure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitorThree new structures of the core domain of HIV-1 integrase: an active site that binds magnesiumHIV-1 integrase catalytic core: molecular dynamics and simulated fluorescence decays.Identification of a nucleotide binding site in HIV-1 integraseMeasuring rapid hydrogen exchange in the homodimeric 36 kDa HIV-1 integrase catalytic core domainHIV virions as nanoscopic test tubes for probing oligomerization of the integrase enzyme.Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.Revealing domain structure through linker-scanning analysis of the murine leukemia virus (MuLV) RNase H and MuLV and human immunodeficiency virus type 1 integrase proteinsGenetic analyses of DNA-binding mutants in the catalytic core domain of human immunodeficiency virus type 1 integrase.The HIV-1 integrase α4-helix involved in LTR-DNA recognition is also a highly antigenic peptide elementSolution conformation and dynamics of the HIV-1 integrase core domain.Sequence specificity of viral end DNA binding by HIV-1 integrase reveals critical regions for protein-DNA interaction.DDE transposases: Structural similarity and diversityStructure-based HIV-1 integrase inhibitor design: a future perspective.Molecular dynamics studies on the HIV-1 integrase catalytic domain.Facile measurement of ¹H-¹5N residual dipolar couplings in larger perdeuterated proteinsMolecular dynamics studies of the wild-type and double mutant HIV-1 integrase complexed with the 5CITEP inhibitor: mechanism for inhibition and drug resistanceLarge-scale conformational dynamics of the HIV-1 integrase core domain and its catalytic loop mutantsA critical role of the C-terminal segment for allosteric inhibitor-induced aberrant multimerization of HIV-1 integrase.Targeting HIV-1 integrase.Human immunodeficiency virus type 1 and related primate lentiviruses engage clathrin through Gag-Pol or Gag.Molecular dynamics approaches estimate the binding energy of HIV-1 integrase inhibitors and correlate with in vitro activity.Structure-based mutagenesis of the catalytic domain of human immunodeficiency virus type 1 integrase.C-Terminal Domain of Integrase Binds between the Two Active SitesA targeted DNA substrate mechanism for the inhibition of HIV-1 integrase by inhibitors with antiretroviral activity.Structural biology of retroviral DNA integration.Structural and functional insights into foamy viral integrasePiecing together the structure of retroviral integrase, an important target in AIDS therapyBiochemical and random mutagenesis analysis of the region carrying the catalytic E152 amino acid of HIV-1 integraseMolecular dynamics of HIV1-integrase in complex with 93del - a structural perspective on the mechanism of inhibition.HIV-1 integrase multimerization as a therapeutic target.Retroviral integrase protein and intasome nucleoprotein complex structures.Mutational scan of the human immunodeficiency virus type 2 integrase protein.Structure-based mutational analysis of the C-terminal DNA-binding domain of human immunodeficiency virus type 1 integrase: critical residues for protein oligomerization and DNA binding.Design, synthesis, and antiviral evaluation of some 3'-carboxymethyl-3'-deoxyadenosine derivatives.Brownian and essential dynamics studies of the HIV-1 integrase catalytic domain.Stabilization of the integrase-DNA complex by Mg2+ ions and prediction of key residues for binding HIV-1 integrase inhibitors.
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P2860
The catalytic domain of human immunodeficiency virus integrase: ordered active site in the F185H mutant
description
1996 nî lūn-bûn
@nan
1996 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
The catalytic domain of human ...... ctive site in the F185H mutant
@ast
The catalytic domain of human ...... ctive site in the F185H mutant
@en
The catalytic domain of human ...... ctive site in the F185H mutant
@nl
type
label
The catalytic domain of human ...... ctive site in the F185H mutant
@ast
The catalytic domain of human ...... ctive site in the F185H mutant
@en
The catalytic domain of human ...... ctive site in the F185H mutant
@nl
prefLabel
The catalytic domain of human ...... ctive site in the F185H mutant
@ast
The catalytic domain of human ...... ctive site in the F185H mutant
@en
The catalytic domain of human ...... ctive site in the F185H mutant
@nl
P2093
P2860
P1433
P1476
The catalytic domain of human ...... ctive site in the F185H mutant
@en
P2093
A Wlodawer
C Clément-Mella
J Alexandratos
P2860
P356
10.1016/S0014-5793(96)01236-7
P407
P577
1996-12-02T00:00:00Z