Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor
about
Coupling between catalytic site and collective dynamics: a requirement for mechanochemical activity of enzymesStructure of the HIV-1 integrase catalytic domain complexed with an inhibitor: a platform for antiviral drug designStructure of a two-domain fragment of HIV-1 integrase: implications for domain organization in the intact protein.Crystal structure of the HIV-1 integrase core domain in complex with sucrose reveals details of an allosteric inhibitory binding siteStructure and inhibition of herpesvirus DNA packaging terminase nuclease domainA Crystal Structure of the Catalytic Core Domain of an Avian Sarcoma and Leukemia Virus Integrase Suggests an Alternate Dimeric AssemblyParallel screening of low molecular weight fragment libraries: do differences in methodology affect hit identification?Structural basis for inactivating mutations and pH-dependent activity of avian sarcoma virus integraseAn inhibitory monoclonal antibody binds at the turn of the helix-turn-helix motif in the N-terminal domain of HIV-1 integrase.Targeting Tn5 transposase identifies human immunodeficiency virus type 1 inhibitors.Peptides derived from the reverse transcriptase of human immunodeficiency virus type 1 as novel inhibitors of the viral integrase.HIV-1 IN inhibitors: 2010 update and perspectivesBiochemical and pharmacological analyses of HIV-1 integrase flexible loop mutants resistant to raltegravirDDE transposases: Structural similarity and diversityDiscovery of a small-molecule HIV-1 integrase inhibitor-binding siteComputational investigation of the anti-HIV activity of Chinese medicinal formula Three-Huang Powder.Prediction of the interaction of HIV-1 integrase and its dicaffeoylquinic acid inhibitor through molecular modeling approachRetroviral integrases promote fraying of viral DNA ends.A targeted DNA substrate mechanism for the inhibition of HIV-1 integrase by inhibitors with antiretroviral activity.Structural biology of retroviral DNA integration.Piecing together the structure of retroviral integrase, an important target in AIDS therapyHIV integrase inhibitor, Elvitegravir, impairs RAG functions and inhibits V(D)J recombination.Role of metal ions in catalysis by HIV integrase analyzed using a quantitative PCR disintegration assay.Computational screening of inhibitors for HIV-1 integrase using a receptor based pharmacophore model.Stabilization of the integrase-DNA complex by Mg2+ ions and prediction of key residues for binding HIV-1 integrase inhibitors.Computer aided study of ligand binding with catalytic domain of Avian sarcoma virus integrase and its ligand binding loops.Characterization of the self association of Avian sarcoma virus integrase by analytical ultracentrifugation.
P2860
Q24549622-803B4A90-DFBA-4B46-8A80-F5080C13419AQ27620348-BA5419FD-AA7E-481A-A1F8-EF0E0078F48DQ27636829-B85EE3BC-EE99-47A4-910D-E2E2C4D03C0FQ27660224-A5EB711E-74B6-409D-AA26-CA87EB6CB9C3Q27664231-08156D2D-F940-47DD-91DD-7F04837DAACCQ27671859-58C0CCFB-61A9-42B4-9EB4-8CC687284780Q27683344-EB0AD0FF-D376-4BE8-AE09-23F82B025DCEQ27766079-53F4997D-7D5B-4CDB-BA16-E0A131A7EDDFQ30915736-7C4116F8-6933-4235-BAD6-B72335374A3EQ31164008-CE51B205-2734-434A-8A5C-FF5EE7C8E4F7Q33213216-47017E43-1187-4326-9669-F8A534C374D7Q33814351-C1B990DE-CD55-4A2D-B75B-03B197FDB4D8Q33838063-15C6EF6F-65F1-4566-B0C1-004E2C1CFE32Q34124977-50D0314B-F86D-4545-84E1-D3C02022F146Q34772524-E27C5F31-4B47-405C-8B92-FDC3F2D9D89CQ34854675-8950BBB1-C554-4311-81AE-C336D7D7C75DQ34952453-D889D444-5C31-4122-BB94-2C9E502897D1Q35110947-78F88AD9-55C7-48F6-8632-CE03399F0F3DQ36766768-90196D96-1445-4959-9C80-B685BE63E866Q36806748-935B149D-DC5B-489F-94C6-2A98051AFBA3Q37353786-DDB213C4-D29C-4ED0-ACC5-7E0278CC7E45Q40177747-98F86061-5394-4C6A-B5C7-2ABB644E1ED9Q40900031-EAA00B59-234C-4AD3-A436-C820E823E1DAQ42119068-DC7A88C1-61BF-4BB7-B6F1-5A04B8B16B50Q42269421-C2F7CC30-50E5-4785-9CF4-5EB2CC3A8D8CQ43853916-6C491C49-9C9C-4440-ADA9-EA24776A8CF7Q43855787-C3F600AE-D21C-400F-8B7F-46126C9BC11F
P2860
Structure of the catalytic domain of avian sarcoma virus integrase with a bound HIV-1 integrase-targeted inhibitor
description
1998 nî lūn-bûn
@nan
1998 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Structure of the catalytic dom ...... 1 integrase-targeted inhibitor
@ast
Structure of the catalytic dom ...... 1 integrase-targeted inhibitor
@en
Structure of the catalytic dom ...... 1 integrase-targeted inhibitor
@nl
type
label
Structure of the catalytic dom ...... 1 integrase-targeted inhibitor
@ast
Structure of the catalytic dom ...... 1 integrase-targeted inhibitor
@en
Structure of the catalytic dom ...... 1 integrase-targeted inhibitor
@nl
prefLabel
Structure of the catalytic dom ...... 1 integrase-targeted inhibitor
@ast
Structure of the catalytic dom ...... 1 integrase-targeted inhibitor
@en
Structure of the catalytic dom ...... 1 integrase-targeted inhibitor
@nl
P2093
P2860
P356
P1476
Structure of the catalytic dom ...... 1 integrase-targeted inhibitor
@en
P2093
A M Skalka
A Wlodawer
J Alexandratos
J Lubkowski
P2860
P304
P356
10.1073/PNAS.95.9.4831
P407
P577
1998-04-28T00:00:00Z