3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes
about
Crystal structure of human wildtype and S581L-mutant glycyl-tRNA synthetase, an enzyme underlying distal spinal muscular atrophyCrystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215.Structure of HIV-1 reverse transcriptase bound to an inhibitor active against mutant reverse transcriptases resistant to other nonnucleoside inhibitors.Discovery of wild-type and Y181C mutant non-nucleoside HIV-1 reverse transcriptase inhibitors using virtual screening with multiple protein structures.Genotypic testing for human immunodeficiency virus type 1 drug resistance.Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.A new antiviral: chimeric 3TC-AZT phosphonate efficiently inhibits HIV-1 in human tissues ex vivo.A Guide to HIV-1 Reverse Transcriptase and Protease Sequencing for Drug Resistance Studies.Zidovudine-didanosine coexposure potentiates DNA incorporation of zidovudine and mutagenesis in human cells.Analysis of the Zidovudine Resistance Mutations T215Y, M41L, and L210W in HIV-1 Reverse Transcriptase.AZT 5'-Phosphonates: Achievements and Trends in the Treatment and Prevention of HIV InfectionAnti-HIV therapy with AZT prodrugs: AZT phosphonate derivatives, current state and prospects.Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNThe Y181C substitution in 3'-azido-3'-deoxythymidine-resistant human immunodeficiency virus, type 1, reverse transcriptase suppresses the ATP-mediated repair of the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer.A family of insertion mutations between codons 67 and 70 of human immunodeficiency virus type 1 reverse transcriptase confer multinucleoside analog resistance.Effects of specific zidovudine resistance mutations and substrate structure on nucleotide-dependent primer unblocking by human immunodeficiency virus type 1 reverse transcriptaseRole of a dipeptide insertion between codons 69 and 70 of HIV-1 reverse transcriptase in the mechanism of AZT resistance.The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.Non-nucleoside inhibitors of HIV-1 reverse transcriptase inhibit phosphorolysis and resensitize the 3'-azido-3'-deoxythymidine (AZT)-resistant polymerase to AZT-5'-triphosphate.Antiretroviral drug resistance testing in adults infected with human immunodeficiency virus type 1: 2003 recommendations of an International AIDS Society-USA Panel.Synthesis of novel homo-N-nucleoside analogs composed of a homo-1,4-dioxane sugar analog and substituted 1,3,5-triazine base equivalents.Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-]pyrimidine non-nucleoside inhibitors
P2860
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P2860
3'-Azido-3'-deoxythymidine drug resistance mutations in HIV-1 reverse transcriptase can induce long range conformational changes
description
1998 nî lūn-bûn
@nan
1998 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
3'-Azido-3'-deoxythymidine dru ...... g range conformational changes
@ast
3'-Azido-3'-deoxythymidine dru ...... g range conformational changes
@en
3'-Azido-3'-deoxythymidine dru ...... g range conformational changes
@nl
type
label
3'-Azido-3'-deoxythymidine dru ...... g range conformational changes
@ast
3'-Azido-3'-deoxythymidine dru ...... g range conformational changes
@en
3'-Azido-3'-deoxythymidine dru ...... g range conformational changes
@nl
prefLabel
3'-Azido-3'-deoxythymidine dru ...... g range conformational changes
@ast
3'-Azido-3'-deoxythymidine dru ...... g range conformational changes
@en
3'-Azido-3'-deoxythymidine dru ...... g range conformational changes
@nl
P2093
P2860
P356
P1476
3'-Azido-3'-deoxythymidine dru ...... g range conformational changes
@en
P2093
A L Hopkins
B A Larder
D I Stuart
D K Stammers
R M Esnouf
P2860
P304
P356
10.1073/PNAS.95.16.9518
P407
P50
P577
1998-08-04T00:00:00Z