Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.
about
K70Q adds high-level tenofovir resistance to "Q151M complex" HIV reverse transcriptase through the enhanced discrimination mechanismStructural basis of HIV-1 resistance to AZT by excisionWhy do HIV-1 and HIV-2 use different pathways to develop AZT resistance?Current perspectives on HIV-1 antiretroviral drug resistanceStructures of HIV-1 reverse transcriptase with pre- and post-translocation AZTMP-terminated DNA.Structural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistanceHIV-1 Reverse Transcriptase (RT) Polymorphism 172K Suppresses the Effect of Clinically Relevant Drug Resistance Mutations to Both Nucleoside and Non-nucleoside RT InhibitorsIncreased multinucleoside drug resistance and decreased replicative capacity of a human immunodeficiency virus type 1 variant with an 8-amino-Acid insert in the reverse transcriptase.Intracellular substrates for the primer-unblocking reaction by human immunodeficiency virus type 1 reverse transcriptase: detection and quantitation in extracts from quiescent- and activated-lymphocyte subpopulations.The Role of Nucleotide Excision by Reverse Transcriptase in HIV Drug Resistance.Structure and function of HIV-1 reverse transcriptase: molecular mechanisms of polymerization and inhibition.HIV-1 reverse transcriptase and antiviral drug resistance. Part 2.Characterization of the polymerase and RNase H activities of human foamy virus reverse transcriptase.Selective modulation of DNA polymerase activity by fixed-conformation nucleoside analogues.Genetic and biochemical diversity in the HCV NS5B RNA polymerase in the context of interferon α plus ribavirin therapy4'-C-methyl-2'-deoxyadenosine and 4'-C-ethyl-2'-deoxyadenosine inhibit HIV-1 replicationStructures of reverse transcriptase pre- and post-excision complexes shed new light on HIV-1 AZT resistanceBiochemical impact of the host adaptation-associated PB2 E627K mutation on the temperature-dependent RNA synthesis kinetics of influenza A virus polymerase complexInsertions in the human immunodeficiency virus type 1 protease and reverse transcriptase genes: clinical impact and molecular mechanisms.Amino acid mutation N348I in the connection subdomain of human immunodeficiency virus type 1 reverse transcriptase confers multiclass resistance to nucleoside and nonnucleoside reverse transcriptase inhibitorsExamining the ribonuclease H primer grip of HIV-1 reverse transcriptase by charge neutralization of RNA/DNA hybridsEffects of the Delta67 complex of mutations in human immunodeficiency virus type 1 reverse transcriptase on nucleoside analog excision.Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations.Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNMolecular mechanisms of tenofovir resistance conferred by human immunodeficiency virus type 1 reverse transcriptase containing a diserine insertion after residue 69 and multiple thymidine analog-associated mutations.The Y181C substitution in 3'-azido-3'-deoxythymidine-resistant human immunodeficiency virus, type 1, reverse transcriptase suppresses the ATP-mediated repair of the 3'-azido-3'-deoxythymidine 5'-monophosphate-terminated primer.Trapping HIV-1 reverse transcriptase before and after translocation on DNA.Effects of dipeptide insertions between codons 69 and 70 of human immunodeficiency virus type 1 reverse transcriptase on primer unblocking, deoxynucleoside triphosphate inhibition, and DNA chain elongation.Structural Aspects of Drug Resistance and Inhibition of HIV-1 Reverse Transcriptase.Biochemical studies on the mechanism of human immunodeficiency virus type 1 reverse transcriptase resistance to 1-(beta-D-dioxolane)thymine triphosphate.AZT resistance of simian foamy virus reverse transcriptase is based on the excision of AZTMP in the presence of ATP.Xenotropic murine leukemia virus-related virus is susceptible to AZT.Altered strand transfer activity of a multiple-drug-resistant human immunodeficiency virus type 1 reverse transcriptase mutant with a dipeptide fingers domain insertion.Evidence for action of ribavirin through the hepatitis C virus RNA polymerase.Structures of HIV-1 RT-DNA complexes before and after incorporation of the anti-AIDS drug tenofovir.Effects of primer-template sequence on ATP-dependent removal of chain-terminating nucleotide analogues by HIV-1 reverse transcriptase.Site-specific footprinting reveals differences in the translocation status of HIV-1 reverse transcriptase. Implications for polymerase translocation and drug resistance.
P2860
Q21135752-E0720E58-C6CD-416E-91B3-5AF744E249EFQ24596976-A79AC4E7-17CC-480C-987F-0E2FAD72B5EAQ25256872-D969623F-62F0-48CB-8829-CB7AA9D8678BQ26852626-76115335-9C31-4103-A83E-C5FF3EFA1EB7Q27640046-E6682A48-5022-4DEF-9385-2566A211BD74Q27657718-C82246DB-A65E-453F-AE88-F27EE2E499E7Q27670634-85E07501-1BB5-4141-9FB7-8677E6AD22C9Q33737755-7B668EA8-10A0-4DFA-85EB-E9A15241A2F0Q33770095-1DF6C0FF-CDFE-403B-95DD-BC69811984E0Q33889635-9A5512D5-0A53-4B0E-9BA7-4A6D95DBB088Q33896402-B455871E-5ABD-4274-8979-C344EEAA28FAQ33900459-6B7DAAF0-A873-4D4E-A448-9C40E228448FQ34186095-AD7DDA63-A5F5-43F3-906C-05561A83618DQ34447677-BB8C695B-8C57-47F6-9CBF-B7F6E709795AQ34577134-9DD0ED68-E5FC-4B48-B3C1-C6158A05B928Q34933164-2AEAAB80-B06A-4568-B72F-028AA8D73ABAQ35258630-8B7264F9-CA98-4016-BC7F-538B4A92F174Q35266435-24618EE6-C28C-43E9-B9D6-04F58CCA6543Q36175788-139D3F0C-B15E-43CC-9649-8BDC2B11F2E7Q36498272-085B3D99-4E04-4C78-9460-330D186BF3B5Q36972129-3A34F27E-31A8-41F9-A512-18E83AA794C9Q37492877-77EADB7F-6A8C-4B9A-8898-D4F40630BD96Q37859395-A1B0A8C6-4CE7-4320-8C6B-96EDE28864DDQ38343144-224FA96B-FECE-4B02-85B1-0FDEFCC838C0Q38344427-CC5BB9AE-5E5D-41E8-B149-943D886DF47EQ38351813-FDAA4CF9-BFBE-4A5F-BD80-5C48E9C154F8Q38358259-C365E214-70B4-4FC8-AF50-BEB6C16FA7F4Q39732544-C5231E07-AE8A-43EC-9F6E-16D48780977FQ39912641-8FFF4D60-7EC2-40F7-B7CB-AF79F23AED27Q41856023-5DDE509F-7FBC-45E2-BC16-E5F0D61828EAQ41878118-6F706ECA-F5C0-47EA-8AFA-2FF1D41167C5Q41879645-5A1B0639-3754-4C7A-9F4D-C4B84248F4F2Q41911362-6BB4954F-3F58-4839-BCA6-72FA7D7AA498Q42861856-906D6A78-7008-4A5B-A48A-0442DA9511B9Q44859710-4C088EF4-5454-4D4A-85D4-D67069326AD6Q45016660-88467B10-1052-4B74-993F-8D7672A32373Q47814140-CA5CBCBC-E495-463D-90FA-DE291F8727BE
P2860
Nucleoside analog resistance caused by insertions in the fingers of human immunodeficiency virus type 1 reverse transcriptase involves ATP-mediated excision.
description
2002 nî lūn-bûn
@nan
2002 թուականի Սեպտեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի սեպտեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Nucleoside analog resistance c ...... nvolves ATP-mediated excision.
@ast
Nucleoside analog resistance c ...... nvolves ATP-mediated excision.
@en
Nucleoside analog resistance c ...... nvolves ATP-mediated excision.
@nl
type
label
Nucleoside analog resistance c ...... nvolves ATP-mediated excision.
@ast
Nucleoside analog resistance c ...... nvolves ATP-mediated excision.
@en
Nucleoside analog resistance c ...... nvolves ATP-mediated excision.
@nl
prefLabel
Nucleoside analog resistance c ...... nvolves ATP-mediated excision.
@ast
Nucleoside analog resistance c ...... nvolves ATP-mediated excision.
@en
Nucleoside analog resistance c ...... nvolves ATP-mediated excision.
@nl
P2860
P1433
P1476
Nucleoside analog resistance c ...... involves ATP-mediated excision
@en
P2093
Edward Arnold
Paul L Boyer
P2860
P304
P356
10.1128/JVI.76.18.9143-9151.2002
P407
P577
2002-09-01T00:00:00Z