Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
about
Proteomics analysis reveals stable multiprotein complexes in both fission and budding yeasts containing Myb-related Cdc5p/Cef1p, novel pre-mRNA splicing factors, and snRNAs.Prp8 protein: at the heart of the spliceosomeCharacterization of U6 snRNA-protein interactions.The network of protein-protein interactions within the human U4/U6.U5 tri-snRNPPre-mRNA splicing alters mRNP composition: evidence for stable association of proteins at exon-exon junctionsAlternative splicing regulation at tandem 3' splice sitesThe architecture of the spliceosomal U4/U6.U5 tri-snRNP.Comprehensive in vivo RNA-binding site analyses reveal a role of Prp8 in spliceosomal assembly.Functional interactions between Prp8, Prp18, Slu7, and U5 snRNA during the second step of pre-mRNA splicing.Characterization of interactions among the Cef1p-Prp19p-associated splicing complexRNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.Computational identification of four spliceosomal snRNAs from the deep-branching eukaryote Giardia intestinalis.Structural and functional analysis of essential pre-mRNA splicing factor Prp19pGenetic and functional interaction of evolutionarily conserved regions of the Prp18 protein and the U5 snRNA.Splint ligation of RNA with T4 DNA ligaseFunctional roles of protein splicing factors.A dynamic bulge in the U6 RNA internal stem-loop functions in spliceosome assembly and activation.A weak spliceosome-binding domain of Yju2 functions in the first step and bypasses Prp16 in the second step of splicingPhysical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosome.Human GC-AG alternative intron isoforms with weak donor sites show enhanced consensus at acceptor exon positions.Genetics and biochemistry remain essential in the structural era of the spliceosome.Cwc21p promotes the second step conformation of the spliceosome and modulates 3' splice site selection.Structural and functional characterization of the N terminus of Schizosaccharomyces pombe Cwf10.Functional contacts with a range of splicing proteins suggest a central role for Brr2p in the dynamic control of the order of events in spliceosomes of Saccharomyces cerevisiae.Dissection of Prp8 protein defines multiple interactions with crucial RNA sequences in the catalytic core of the spliceosome.Regulation of constitutive and alternative mRNA splicing across the human transcriptome by PRPF8 is determined by 5' splice site strength.
P2860
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P2860
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
description
1998 nî lūn-bûn
@nan
1998 թուականի Դեկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի դեկտեմբերին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
@ast
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
@en
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
@nl
type
label
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
@ast
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
@en
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
@nl
altLabel
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae
@en
prefLabel
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
@ast
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
@en
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
@nl
P2093
P1433
P1476
Protein-RNA interactions in the U5 snRNP of Saccharomyces cerevisiae.
@en
P2093
P304
P356
10.1017/S1355838298412998
P407
P577
1998-12-01T00:00:00Z