hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
about
The RAD2 domain of human exonuclease 1 exhibits 5' to 3' exonuclease and flap structure-specific endonuclease activitiesThe interaction of DNA mismatch repair proteins with human exonuclease IhMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.Highlight: BRCA1 and BRCA2 proteins in breast cancerDifferential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sitesPhysical and functional interactions between Werner syndrome helicase and mismatch-repair initiation factorsATM-mediated stabilization of hMutL DNA mismatch repair proteins augments p53 activation during DNA damagehMSH3 and hMSH6 interact with PCNA and colocalize with it to replication fociMechanism of mismatch recognition revealed by human MutSĪ² bound to unpaired DNA loopshMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machineryInteraction between the Msh2 and Msh6 nucleotide-binding sites in the Saccharomyces cerevisiae Msh2-Msh6 complexN-terminus of hMLH1 confers interaction of hMutLalpha and hMutLbeta with hMutSalphaSingle-molecule views of MutS on mismatched DNA.The alternating ATPase domains of MutS control DNA mismatch repairMagnesium Coordination Controls the Molecular Switch Function of DNA Mismatch Repair Protein MutSStructures of Human Exonuclease 1 DNA Complexes Suggest a Unified Mechanism for Nuclease FamilyDiscovery of a new motion mechanism of biomotors similar to the earth revolving around the sun without rotation.New insights into the mechanism of DNA mismatch repairDNA mismatch repair and mutation avoidance pathwaysAdenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1Exonuclease 1-dependent and independent mismatch repairLarge conformational changes in MutS during DNA scanning, mismatch recognition and repair signalling.DNA mismatch repair in eukaryotes and bacteriaNucleotides and heteroduplex DNA preserve the active conformation of Pseudomonas aeruginosa MutS by preventing protein oligomerizationThe role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switchDNA repair mechanisms and the bypass of DNA damage in Saccharomyces cerevisiaeMechanism of MutS searching for DNA mismatches and signaling repairMany ways to loop DNA.Dynamic basis for one-dimensional DNA scanning by the mismatch repair complex Msh2-Msh6.Chemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli.Single-molecule imaging reveals target-search mechanisms during DNA mismatch repair.Mismatch repair protein hMSH2-hMSH6 recognizes mismatches and forms sliding clamps within a D-loop recombination intermediateRegulation of replication protein A functions in DNA mismatch repair by phosphorylation.A conserved MutS homolog connector domain interface interacts with MutL homologs.Interaction of MutS and Vsr: some dominant-negative mutS mutations that disable methyladenine-directed mismatch repair are active in very-short-patch repair.Saccharomyces cerevisiae Msh2-Msh6 DNA binding kinetics reveal a mechanism of targeting sites for DNA mismatch repair.Nuclear reorganization of DNA mismatch repair proteins in response to DNA damage.The biochemical basis of microsatellite instability and abnormal immunohistochemistry and clinical behavior in Lynch syndrome: from bench to bedsideProbing DNA- and ATP-mediated conformational changes in the MutS family of mispair recognition proteins using deuterium exchange mass spectrometry.Genomic and epigenetic instability in colorectal cancer pathogenesis.
P2860
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P2860
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
description
1999 nĆ® lÅ«n-bĆ»n
@nan
1999 Õ©ÕøÖÕ”ÕÆÕ”Õ¶Õ« ÕÕ„ÕæÖÕøÖÕ”ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕøÖÕ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ ÕµÖ
Õ¤ÕøÖÕ”Õ®
@hyw
1999 Õ©Õ¾Õ”ÕÆÕ”Õ¶Õ« ÖÕ„ÕæÖÕ¾Õ”ÖÕ«Õ¶ Õ°ÖÕ”ÕæÕ”ÖÕ”ÕÆÕ¾Õ”Õ® Õ£Õ«ÕæÕ”ÕÆÕ”Õ¶ Õ°ÕøÕ¤Õ¾Õ”Õ®
@hy
1999幓ć®č«ę
@ja
1999幓č«ę
@yue
1999幓č«ę
@zh-hant
1999幓č«ę
@zh-hk
1999幓č«ę
@zh-mo
1999幓č«ę
@zh-tw
1999幓č®ŗę
@wuu
name
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
@ast
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
@en
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
@nl
type
label
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
@ast
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
@en
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
@nl
prefLabel
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
@ast
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
@en
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
@nl
P2093
P3181
P1433
P1476
hMSH2-hMSH6 forms a hydrolysis-independent sliding clamp on mismatched DNA
@en
P2093
D Subramanian
J Griffith
P304
P3181
P356
10.1016/S1097-2765(00)80316-0
P407
P577
1999-02-01T00:00:00Z