The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
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Interactions between p53, hMSH2-hMSH6 and HMG I(Y) on Holliday junctions and bulged basesDifferential specificities and simultaneous occupancy of human MutSalpha nucleotide binding siteshMSH4-hMSH5 adenosine nucleotide processing and interactions with homologous recombination machineryDetermination of protein-DNA binding constants and specificities from statistical analyses of single molecules: MutS-DNA interactionsSingle-molecule views of MutS on mismatched DNA.Crystal structure and biochemical analysis of the MutS.ADP.beryllium fluoride complex suggests a conserved mechanism for ATP interactions in mismatch repairIdentification of mismatch repair protein complexes in HeLa nuclear extracts and their interaction with heteroduplex DNAAdenosine nucleotide modulates the physical interaction between hMSH2 and BRCA1Structural, molecular and cellular functions of MSH2 and MSH6 during DNA mismatch repair, damage signaling and other noncanonical activitiesMutSβ promotes trinucleotide repeat expansion by recruiting DNA polymerase β to nascent (CAG)n or (CTG)n hairpins for error-prone DNA synthesisChemical trapping of the dynamic MutS-MutL complex formed in DNA mismatch repair in Escherichia coli.Human MutL homolog (MLH1) function in DNA mismatch repair: a prospective screen for missense mutations in the ATPase domain.Saccharomyces cerevisiae Msh2-Msh6 DNA binding kinetics reveal a mechanism of targeting sites for DNA mismatch repair.Role of the dinB gene product in spontaneous mutation in Escherichia coli with an impaired replicative polymerase.BRCA1 and cell signaling.The nucleotide binding dynamics of human MSH2-MSH3 are lesion dependentThe mechanism of mismatch repair and the functional analysis of mismatch repair defects in Lynch syndrome.MutS switches between two fundamentally distinct clamps during mismatch repair.Signaling mismatch repair: the mechanics of an adenosine-nucleotide molecular switch.DNA mismatch repair: from structure to mechanism.Mismatch repair during homologous and homeologous recombinationA quantitative model of nucleosome dynamics.Hijacking of the mismatch repair system to cause CAG expansion and cell death in neurodegenerative disease.Chromosomal directionality of DNA mismatch repair in Escherichia coliMismatch repairThe hMSH2(M688R) Lynch syndrome mutation may function as a dominant negative.Sequence context effect for hMSH2-hMSH6 mismatch-dependent activation.Mismatch recognition protein MutSbeta does not hijack (CAG)n hairpin repair in vitro.Evidence that nucleosomes inhibit mismatch repair in eukaryotic cellsDNA mismatch repair (MMR)-dependent 5-fluorouracil cytotoxicity and the potential for new therapeutic targets.ATP alters the diffusion mechanics of MutS on mismatched DNA.Recognition of damaged DNA: structure and dynamic markers.Dominant Saccharomyces cerevisiae msh6 mutations cause increased mispair binding and decreased dissociation from mispairs by Msh2-Msh6 in the presence of ATP.Understanding how mismatch repair proteins participate in the repair/anti-recombination decision.Mismatch recognition-coupled stabilization of Msh2-Msh6 in an ATP-bound state at the initiation of DNA repair.Asymmetric ATP binding and hydrolysis activity of the Thermus aquaticus MutS dimer is key to modulation of its interactions with mismatched DNA.DNA mismatch repair-dependent response to fluoropyrimidine-generated damage.ATP binding and hydrolysis by Saccharomyces cerevisiae Msh2-Msh3 are differentially modulated by mismatch and double-strand break repair DNA substrates.Distinct requirements within the Msh3 nucleotide binding pocket for mismatch and double-strand break repair.Nucleosome remodeling by hMSH2-hMSH6.
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P2860
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
description
2000 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2000
@ast
im Februar 2000 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2000/02/11)
@sk
vědecký článek publikovaný v roce 2000
@cs
wetenschappelijk artikel (gepubliceerd op 2000/02/11)
@nl
наукова стаття, опублікована в лютому 2000
@uk
name
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
@ast
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
@en
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
@nl
type
label
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
@ast
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
@en
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
@nl
prefLabel
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
@ast
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
@en
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
@nl
P2093
P2860
P3181
P356
P1476
The role of mismatched nucleotides in activating the hMSH2-hMSH6 molecular switch
@en
P2093
P2860
P304
P3181
P356
10.1074/JBC.275.6.3922
P407
P577
2000-02-11T00:00:00Z