Ovarian tumor cells express a transmembrane serine protease: a potential candidate for early diagnosis and therapeutic intervention
about
Matriptase-3 is a novel phylogenetically preserved membrane-anchored serine protease with broad serpin reactivityMouse DESC1 is located within a cluster of seven DESC1-like genes and encodes a type II transmembrane serine protease that forms serpin inhibitory complexesStructure of catalytic domain of Matriptase in complex with Sunflower trypsin inhibitor-1Favorable prognostic value of tissue human kallikrein 11 (hK11) in patients with ovarian carcinomaThe activation of matriptase requires its noncatalytic domains, serine protease domain, and its cognate inhibitorInhibition of tumor invasion by genomic down-regulation of matriptase through suppression of activation of receptor-bound pro-urokinaseAssembly of adherens junctions is required for sphingosine 1-phosphate-induced matriptase accumulation and activation at mammary epithelial cell-cell contactsMouse matriptase-2: identification, characterization and comparative mRNA expression analysis with mouse hepsin in adult and embryonic tissuesThe ratio of Matriptase/HAI-1 mRNA is higher in colorectal cancer adenomas and carcinomas than corresponding tissue from control individuals.Expression and prognostic value of matriptase in ovarian serous adenocarcinomaType II transmembrane serine protease gene variants associate with breast cancer.Deregulated matriptase causes ras-independent multistage carcinogenesis and promotes ras-mediated malignant transformation.Matriptase is involved in ErbB-2-induced prostate cancer cell invasionA pan-cancer analysis of alternative splicing events reveals novel tumor-associated splice variants of matriptase.Novel target antigens for dendritic cell-based immunotherapy against ovarian cancer.Matriptase: potent proteolysis on the cell surface.Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesisPossible role of matriptase in the diagnosis of ovarian cancer.Suppression of Tumorigenicity-14, encoding matriptase, is a critical suppressor of colitis and colitis-associated colon carcinogenesisPlatelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progressionTransmembrane serine protease TADG-15 (ST14/Matriptase/MT-SP1): expression and prognostic value in ovarian cancer.Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1.Type II transmembrane serine proteases as potential targets for cancer therapy.Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality.Matriptase: a culprit in cancer?Ovarian tumor ascites CD14+ cells suppress dendritic cell-activated CD4+ T-cell responses through IL-10 secretion and indoleamine 2,3-dioxygenase.Decreasing the ratio of matriptase/HAI‑1 by downregulation of matriptase as a potential adjuvant therapy in ovarian cancer.Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase.Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain.HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease.Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells.Spinesin/TMPRSS5, a novel transmembrane serine protease, cloned from human spinal cord.Characterization of matriptase expression in normal human tissues.Human kallikrein 6 activity is regulated via an autoproteolytic mechanism of activation/inactivation.Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells.Expression of serine protease matriptase in renal cell carcinoma: correlation of tissue microarray immunohistochemical expression analysis results with clinicopathological parameters.
P2860
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P2860
Ovarian tumor cells express a transmembrane serine protease: a potential candidate for early diagnosis and therapeutic intervention
description
2001 nî lūn-bûn
@nan
2001 թուականին հրատարակուած գիտական յօդուած
@hyw
2001 թվականին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
Ovarian tumor cells express a ...... s and therapeutic intervention
@ast
Ovarian tumor cells express a ...... s and therapeutic intervention
@en
Ovarian tumor cells express a ...... s and therapeutic intervention
@nl
type
label
Ovarian tumor cells express a ...... s and therapeutic intervention
@ast
Ovarian tumor cells express a ...... s and therapeutic intervention
@en
Ovarian tumor cells express a ...... s and therapeutic intervention
@nl
prefLabel
Ovarian tumor cells express a ...... s and therapeutic intervention
@ast
Ovarian tumor cells express a ...... s and therapeutic intervention
@en
Ovarian tumor cells express a ...... s and therapeutic intervention
@nl
P2093
P3181
P356
P1433
P1476
Ovarian tumor cells express a ...... s and therapeutic intervention
@en
P2093
H Tanimoto
K Shigemasa
L J Underwood
T H Parmley
T J O'Brien
P2888
P304
P3181
P356
10.1159/000050604
P407
P577
2001-01-01T00:00:00Z
P6179
1018749967