Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells.
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Human cancer cells retain modest levels of enzymatically active matriptase only in extracellular milieu following induction of zymogen activationMatriptase autoactivation is tightly regulated by the cellular chemical environmentsCleavage of influenza virus hemagglutinin by airway proteases TMPRSS2 and HAT differs in subcellular localization and susceptibility to protease inhibitorsMatriptase activation, an early cellular response to acidosis.Matriptase zymogen supports epithelial development, homeostasis and regenerationTargeting zymogen activation to control the matriptase-prostasin proteolytic cascade.The protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.Regulation of the matriptase-prostasin cell surface proteolytic cascade by hepatocyte growth factor activator inhibitor-1 during epidermal differentiationMatriptase is involved in ErbB-2-induced prostate cancer cell invasionIncreased matriptase zymogen activation in inflammatory skin disorders.Antithrombin regulates matriptase activity involved in plasmin generation, syndecan shedding, and HGF activation in keratinocytes.Matriptase: potent proteolysis on the cell surface.HAI-2 suppresses the invasive growth and metastasis of prostate cancer through regulation of matriptase.Differential subcellular localization renders HAI-2 a matriptase inhibitor in breast cancer cells but not in mammary epithelial cellsExpression of serine protease SNC19/matriptase and its inhibitor hepatocyte growth factor activator inhibitor type 1 in normal and malignant tissues of gastrointestinal tract.N-Glycan Branching Affects the Subcellular Distribution of and Inhibition of Matriptase by HAI-2/Placental BikuninMechanisms for the control of matriptase activity in the absence of sufficient HAI-1Probing the interaction mechanism of small molecule inhibitors with matriptase based on molecular dynamics simulation and free energy calculations.Matriptase Complexes and Prostasin Complexes with HAI-1 and HAI-2 in Human Milk: Significant Proteolysis in LactationNatural Endogenous Human Matriptase and Prostasin Undergo Zymogen Activation via Independent Mechanisms in an Uncoupled Manner.Selective Inhibition of Prostasin in Human Enterocytes by the Integral Membrane Kunitz-Type Serine Protease Inhibitor HAI-2Reinforced Epithelial Barrier Integrity via Matriptase Induction with Sphingosine-1-Phosphate Did Not Result in Disturbances in Physiological Redox Status.Prostasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.Purification from human milk of matriptase complexes with secreted serpins: mechanism for inhibition of matriptase other than HAI-1.Matriptase activation and shedding through PDGF-D-mediated extracellular acidosis.Imbalanced matriptase pericellular proteolysis contributes to the pathogenesis of malignant B-cell lymphomas.Polarized epithelial cells secrete matriptase as a consequence of zymogen activation and HAI-1-mediated inhibition.Matriptase and prostasin are expressed in human skin in an inverse trend over the course of differentiation and are targeted to different regions of the plasma membrane.Matriptase: a culprit in cancer?The basal chorionic trophoblast cell layer: An emerging coordinator of placenta development.Persistent elevation of hepatocyte growth factor activator inhibitors in cholangiopathies affects liver fibrosis and differentiation.Mesothelial cells activate the plasma kallikrein-kinin system during pleural inflammation.Delineation of proteolytic and non-proteolytic functions of the membrane-anchored serine protease prostasin.Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface.Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain.HAI-1 regulates activation and expression of matriptase, a membrane-bound serine protease.Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.Matriptase activation and shedding with HAI-1 is induced by steroid sex hormones in human prostate cancer cells, but not in breast cancer cells.The Kunitz Domain I of Hepatocyte Growth Factor Activator Inhibitor-2 Inhibits Matriptase Activity and Invasive Ability of Human Prostate Cancer Cells.Inhibition of cyclooxygenase-2-mediated matriptase activation contributes to the suppression of prostate cancer cell motility and metastasis.
P2860
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P2860
Simultaneous activation and hepatocyte growth factor activator inhibitor 1-mediated inhibition of matriptase induced at activation foci in human mammary epithelial cells.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Simultaneous activation and he ...... uman mammary epithelial cells.
@en
type
label
Simultaneous activation and he ...... uman mammary epithelial cells.
@en
prefLabel
Simultaneous activation and he ...... uman mammary epithelial cells.
@en
P2093
P2860
P1476
Simultaneous activation and he ...... human mammary epithelial cells
@en
P2093
Chen-Yong Lin
Christelle Benaud
Ken-ichi Kiyomiya
Robert B Dickson
P2860
P304
P356
10.1152/AJPCELL.00497.2004
P577
2004-12-08T00:00:00Z