Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis
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Regulation of cell surface protease matriptase by HAI2 is essential for placental development, neural tube closure and embryonic survival in miceHATL5: a cell surface serine protease differentially expressed in epithelial cancersMatriptase initiates activation of epidermal pro-kallikrein and disease onset in a mouse model of Netherton syndromeReduced prostasin (CAP1/PRSS8) activity eliminates HAI-1 and HAI-2 deficiency-associated developmental defects by preventing matriptase activationTMPRSS13 deficiency impairs stratum corneum formation and epidermal barrier acquisitionDisruption of epidermal specific gene expression and delayed skin development in AP-2 gamma mutant miceMatriptase zymogen supports epithelial development, homeostasis and regenerationThe level of claudin-7 is reduced as an early event in colorectal carcinogenesis.Membrane-anchored serine proteases in vertebrate cell and developmental biologyNon-hematopoietic PAR-2 is essential for matriptase-driven pre-malignant progression and potentiation of ras-mediated squamous cell carcinogenesisThe protease inhibitor HAI-2, but not HAI-1, regulates matriptase activation and shedding through prostasin.Endogenous expression of matriptase in neural progenitor cells promotes cell migration and neuron differentiation.Matriptase: potent proteolysis on the cell surface.c-Met-induced epithelial carcinogenesis is initiated by the serine protease matriptaseDetection of active matriptase using a biotinylated chloromethyl ketone peptideMatriptase deletion initiates a Sjögren's syndrome-like disease in mice.Autosomal recessive ichthyosis with hypotrichosis caused by a mutation in ST14, encoding type II transmembrane serine protease matriptase.Androgen receptor non-nuclear regulation of prostate cancer cell invasion mediated by Src and matriptase.Platelet-derived growth factor-C (PDGF-C) activation by serine proteases: implications for breast cancer progressionTargeting matriptase in breast cancer abrogates tumour progression via impairment of stromal-epithelial growth factor signalling.Hepatocyte growth factor activator inhibitor-2 prevents shedding of matriptaseHepatocyte growth factor activator inhibitor-1 has a complex subcellular itineraryProstasin is required for matriptase activation in intestinal epithelial cells to regulate closure of the paracellular pathway.The cutting edge: membrane-anchored serine protease activities in the pericellular microenvironment.Potent inhibition and global co-localization implicate the transmembrane Kunitz-type serine protease inhibitor hepatocyte growth factor activator inhibitor-2 in the regulation of epithelial matriptase activity.Membrane-anchored serine proteases in health and disease.Loss of matriptase suppression underlies spint1 mutation-associated ichthyosis and postnatal lethality.Epithelial integrity is maintained by a matriptase-dependent proteolytic pathway.Matriptase: a culprit in cancer?Matriptase expression and zymogen activation in human pilosebaceous unit.Matriptase-deficient mice exhibit ichthyotic skin with a selective shift in skin microbiota.The matriptase-prostasin proteolytic cascade in epithelial development and pathology.Filaggrin - revisited.Mechanisms of hepatocyte growth factor activation in cancer tissues.Regulation of microRNA expression by hepatocyte growth factor in human head and neck squamous cell carcinoma.The role of type II transmembrane serine protease-mediated signaling in cancer.Strong expression association between matriptase and its substrate prostasin in breast cancer.Defect of hepatocyte growth factor activator inhibitor type 1/serine protease inhibitor, Kunitz type 1 (Hai-1/Spint1) leads to ichthyosis-like condition and abnormal hair development in mice.Autoactivation of matriptase in vitro: requirement for biomembrane and LDL receptor domain.Matriptase shedding is closely coupled with matriptase zymogen activation and requires de novo proteolytic cleavage likely involving its own activity.
P2860
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P2860
Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis
description
2006 nî lūn-bûn
@nan
2006 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2006年の論文
@ja
2006年論文
@yue
2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
@zh-mo
2006年論文
@zh-tw
2006年论文
@wuu
name
Delineation of matriptase prot ...... d squamous cell carcinogenesis
@ast
Delineation of matriptase prot ...... d squamous cell carcinogenesis
@en
type
label
Delineation of matriptase prot ...... d squamous cell carcinogenesis
@ast
Delineation of matriptase prot ...... d squamous cell carcinogenesis
@en
prefLabel
Delineation of matriptase prot ...... d squamous cell carcinogenesis
@ast
Delineation of matriptase prot ...... d squamous cell carcinogenesis
@en
P2093
P2860
P1476
Delineation of matriptase prot ...... d squamous cell carcinogenesis
@en
P2093
Alfredo Molinolo
Boye Schnack Nielsen
Karin List
Roman Szabo
P2860
P304
P356
10.2353/AJPATH.2006.051071
P407
P577
2006-05-01T00:00:00Z