The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability
about
The base excision repair enzyme MED1 mediates DNA damage response to antitumor drugs and is associated with mismatch repair system integrityFas-associated death domain protein interacts with methyl-CpG binding domain protein 4: a potential link between genome surveillance and apoptosisThe thymine DNA glycosylase MBD4 represses transcription and is associated with methylated p16(INK4a) and hMLH1 genesMechanism of transcriptional regulation by methyl-CpG binding protein MBD1Modifiers and Readers of DNA Modifications and Their Impact on Genome Structure, Expression, and Stability in DiseaseThe clinical value of aberrant epigenetic changes of DNA damage repair genes in human cancerMismatch Repair in Methylated DNA: STRUCTURE AND ACTIVITY OF THE MISMATCH-SPECIFIC THYMINE GLYCOSYLASE DOMAIN OF METHYL-CpG-BINDING PROTEIN MBD4Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylationStructural Basis of the Versatile DNA Recognition Ability of the Methyl-CpG Binding Domain of Methyl-CpG Binding Domain Protein 4DNA methylation, its mediators and genome integrityBiphasic kinetics of the human DNA repair protein MED1 (MBD4), a mismatch-specific DNA N-glycosylaseMBD2-MBD3 complex binds to hemi-methylated DNA and forms a complex containing DNMT1 at the replication foci in late S phaseThe mCpG-binding domain of human MBD3 does not bind to mCpG but interacts with NuRD/Mi2 components HDAC1 and MTA2MBD4 interacts with and recruits USP7 to heterochromatic fociRole of base excision repair in maintaining the genetic and epigenetic integrity of CpG sitesInvolvement of MBD4 inactivation in mismatch repair-deficient tumorigenesisMBD4 and TDG: multifaceted DNA glycosylases with ever expanding biological rolesBase excision repairEpigenetic downregulation of the DNA repair gene MED1/MBD4 in colorectal and ovarian cancerLack of the matricellular protein SPARC (secreted protein, acidic and rich in cysteine) attenuates liver fibrogenesis in miceMolecular biology of Barrett's adenocarcinoma.Methyl CpG binding proteins: coupling chromatin architecture to gene regulation.MBDin, a novel MBD2-interacting protein, relieves MBD2 repression potential and reactivates transcription from methylated promoters.Epithelial and stromal genetic instability linked to tumor suppressor genes in ulcerative colitis-associated tumorigenesis.Single nucleotide polymorphism in the methyl-CpG binding domain 4 gene and the risk for immune thrombocytopenic purpura in Chinese population.Human DNA mismatch repair in vitro operates independently of methylation status at CpG sitesGermline and somatic mutation analyses in the DNA mismatch repair gene MLH3: Evidence for somatic mutation in colorectal cancers.Functional significance of concomitant inactivation of hMLH1 and hMSH6 in tumor cells of the microsatellite mutator phenotype.Mbd4 inactivation increases Cright-arrowT transition mutations and promotes gastrointestinal tumor formation.Carcinogenesis in the GI tract: from morphology to genetics and back again.Role of MED1 (MBD4) Gene in DNA repair and human cancer.Functional interactions and signaling properties of mammalian DNA mismatch repair proteins.MeCP2 and other methyl-CpG binding proteins.Methyl-CpG binding proteins and cancer: are MeCpGs more important than MBDs?Tumor-infiltrating lymphocytes in colorectal cancers with microsatellite instability are correlated with the number and spectrum of frameshift mutations.Sporadic breast cancer patients' germline DNA exhibit an AT-rich microsatellite signature.Assembly of a comprehensive regulatory network for the mammalian circadian clock: a bioinformatics approachA role for p300/CREB binding protein genes in promoting cancer progression in colon cancer cell lines with microsatellite instabilityEpigenetics provides a new generation of oncogenes and tumour-suppressor genes.H3K9 trimethylation precedes DNA methylation during sheep oogenesis: HDAC1, SUV39H1, G9a, HP1, and Dnmts are involved in these epigenetic events
P2860
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P2860
The DNA repair gene MBD4 (MED1) is mutated in human carcinomas with microsatellite instability
description
1999 nî lūn-bûn
@nan
1999 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
name
The DNA repair gene MBD4 (MED1 ...... ith microsatellite instability
@ast
The DNA repair gene MBD4 (MED1 ...... ith microsatellite instability
@en
The DNA repair gene MBD4 (MED1 ...... ith microsatellite instability
@nl
type
label
The DNA repair gene MBD4 (MED1 ...... ith microsatellite instability
@ast
The DNA repair gene MBD4 (MED1 ...... ith microsatellite instability
@en
The DNA repair gene MBD4 (MED1 ...... ith microsatellite instability
@nl
prefLabel
The DNA repair gene MBD4 (MED1 ...... ith microsatellite instability
@ast
The DNA repair gene MBD4 (MED1 ...... ith microsatellite instability
@en
The DNA repair gene MBD4 (MED1 ...... ith microsatellite instability
@nl
P2093
P3181
P356
P1433
P1476
The DNA repair gene MBD4 (MED1 ...... ith microsatellite instability
@en
P2093
A Bellacosa
A J Klein-Szanto
A K Godwin
B A Ruggeri
L A Aaltonen
P2888
P3181
P356
10.1038/15443
P407
P577
1999-11-01T00:00:00Z