Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity. - Wikidata - wikimedia - TriplyDB

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.

Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.

http://www.wikidata.org/entity/Q42153057

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Harnessing Mechanistic Knowledge on Beneficial Versus Deleterious IFN-I Effects to Design Innovative Immunotherapies Targeting Cytokine Activity to Specific Cell Types Zika Virus Infects Human Placental Macrophages Inhibition of the type I interferon response in human dendritic cells by dengue virus infection requires a catalytically active NS2B3 complex Immune Activation in the Liver by Nucleic Acids Regulation of type I interferon responses Intracellular nucleic acid sensors and autoimmunity Protein kinase PKR and RNA adenosine deaminase ADAR1: new roles for old players as modulators of the interferon response The battle between rotavirus and its host for control of the interferon signaling pathway Innate immune responses in hepatitis C virus infection Intradermal electroporation of naked replicon RNA elicits strong immune responses Diverse Strategies Used by Picornaviruses to Escape Host RNA Decay Pathways The interferon-inducible gene viperin restricts West Nile virus pathogenesis Zika Virus Antagonizes Type I Interferon Responses during Infection of Human Dendritic Cells PKR mediated regulation of inflammation and IL-10 during viral encephalomyelitis.Incoming RNA virus nucleocapsids containing a 5'-triphosphorylated genome activate RIG-I and antiviral signaling Innate immunity to influenza virus infection.Interplay between innate immunity and negative-strand RNA viruses: towards a rational model Induction of GADD34 is necessary for dsRNA-dependent interferon-β production and participates in the control of Chikungunya virus infection.Interferon-induced Ifit2/ISG54 protects mice from lethal VSV neuropathogenesis.Critical role of an antiviral stress granule containing RIG-I and PKR in viral detection and innate immunity.Interferon-stimulated genes: a complex web of host defenses.Protein kinase regulated by dsRNA downregulates the interferon production in dengue virus- and dsRNA-stimulated human lung epithelial cells Recombinant modified vaccinia virus Ankara generating excess early double-stranded RNA transiently activates protein kinase R and triggers enhanced innate immune responses.The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon.RIG-I and MDA-5 detection of viral RNA-dependent RNA polymerase activity restricts positive-strand RNA virus replication Strategies for viral RNA stability: live long and prosper The early interferon response to rotavirus is regulated by PKR and depends on MAVS/IPS-1, RIG-I, MDA-5, and IRF3.Bioinformatics multivariate analysis determined a set of phase-specific biomarker candidates in a novel mouse model for viral myocarditis.DHX36 enhances RIG-I signaling by facilitating PKR-mediated antiviral stress granule formation Interferon-stimulated genes and their antiviral effector functions Protein phosphatase 1 subunit Ppp1r15a/GADD34 regulates cytokine production in polyinosinic:polycytidylic acid-stimulated dendritic cells.TLR3 signaling is either protective or pathogenic for the development of Theiler's virus-induced demyelinating disease depending on the time of viral infection Adenosine deaminase acting on RNA 1 (ADAR1) suppresses the induction of interferon by measles virus.Protein kinase PKR catalytic activity is required for the PKR-dependent activation of mitogen-activated protein kinases and amplification of interferon beta induction following virus infection.Superior induction of T cell responses to conserved HIV-1 regions by electroporated alphavirus replicon DNA compared to that with conventional plasmid DNA vaccine.The double-stranded RNA bluetongue virus induces type I interferon in plasmacytoid dendritic cells via a MYD88-dependent TLR7/8-independent signaling pathway.PKR Transduces MDA5-Dependent Signals for Type I IFN Induction.Cell-intrinsic innate immune control of West Nile virus infection.Protein kinase PKR amplification of interferon β induction occurs through initiation factor eIF-2α-mediated translational control RIPK3 interacts with MAVS to regulate type I IFN-mediated immunity to Influenza A virus infection

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Protein kinase R contributes to immunity against specific viruses by regulating interferon mRNA integrity.

http://www.wikidata.org/entity/Q42153057

description

2010 nî lūn-bûn

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2010年の論文

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年学术文章

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2010年學術文章

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2010年學術文章

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2010年學術文章

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name

Protein kinase R contributes t ...... ing interferon mRNA integrity.

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Protein kinase R contributes t ...... ing interferon mRNA integrity.

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type

label

Protein kinase R contributes t ...... ing interferon mRNA integrity.

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Protein kinase R contributes t ...... ing interferon mRNA integrity.

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Protein kinase R contributes t ...... ing interferon mRNA integrity.

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Protein kinase R contributes t ...... ing interferon mRNA integrity.

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J.CHOM.2010.04.007

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Cell Host & Microbe

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Protein kinase R contributes t ...... ing interferon mRNA integrity.

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Andreas Pichlmair

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Donalyn Scheuner

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Hiroki Kato

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Neil C Rogers

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Oliver Schulz

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Osamu Takeuchi

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Randal J Kaufman

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P2860

The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein kinase PKR

mda-5: An interferon-inducible putative RNA helicase with double-stranded RNA-dependent ATPase activity and melanoma growth-suppressive properties

Antiviral actions of interferons

Impact of protein kinase PKR in cell biology: from antiviral to antiproliferative action

West Nile Virus-Induced Interferon Production Is Mediated by the Double-Stranded RNA-Dependent Protein Kinase PKR

Establishment and Maintenance of the Innate Antiviral Response to West Nile Virus Involves both RIG-I and MDA5 Signaling through IPS-1

Processing of Genome 5′ Termini as a Strategy of Negative-Strand RNA Viruses to Avoid RIG-I-Dependent Interferon Induction

The RNA-activated Protein Kinase Enhances the Induction of Interferon- and Apoptosis Mediated by Cytoplasmic RNA Sensors

Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses

The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses

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354-361

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10.1016/J.CHOM.2010.04.007

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5

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7

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Caetano Reis e Sousa

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2010-05-01T00:00:00Z

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44607573

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