mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic
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Interleukin-24 and its receptorsUnfolding the Role of Large Heat Shock Proteins: New Insights and Therapeutic ImplicationsStem cells as cellular vehicles for gene therapy against glioblastomaDeveloping an effective gene therapy for prostate cancer: New technologies with potential to translate from the laboratory into the clinicA novel splicing variant of mouse interleukin (IL)-24 antagonizes IL-24-induced apoptosisTargeting a newly established spontaneous feline fibrosarcoma cell line by gene transferCisplatin enhances protein kinase R-like endoplasmic reticulum kinase- and CD95-dependent melanoma differentiation-associated gene-7/interleukin-24-induced killing in ovarian carcinoma cellsEradication of therapy-resistant human prostate tumors using an ultrasound-guided site-specific cancer terminator virus delivery approach.Targeting gene expression selectively in cancer cells by using the progression-elevated gene-3 promoter.Mechanism of autophagy to apoptosis switch triggered in prostate cancer cells by antitumor cytokine melanoma differentiation-associated gene 7/interleukin-24MDA-7/IL-24-induced cell killing in malignant renal carcinoma cells occurs by a ceramide/CD95/PERK-dependent mechanism.Inhibition of multiple protective signaling pathways and Ad.5/3 delivery enhances mda-7/IL-24 therapy of malignant gliomaPERK-dependent regulation of ceramide synthase 6 and thioredoxin play a key role in mda-7/IL-24-induced killing of primary human glioblastoma multiforme cells.Characterization of the canine mda-7 gene, transcripts and expression patterns.Dual cancer-specific targeting strategy cures primary and distant breast carcinomas in nude mice.Tumour suppressor function of MDA-7/IL-24 in human breast cancerEnhanced apoptosis-inducing function of MDA-7/IL-24 RGD mutant via the increased adhesion to tumor cells.IL-24 gene transfer sensitizes melanoma cells to erlotinib through modulation of the Apaf-1 and Akt signaling pathways.The development of MDA-7/IL-24 as a cancer therapeuticSecretable chaperone Grp170 enhances therapeutic activity of a novel tumor suppressor, mda-7/IL-24A serotype 5/3 adenovirus expressing MDA-7/IL-24 infects renal carcinoma cells and promotes toxicity of agents that increase ROS and ceramide levels.Reversing translational suppression and induction of toxicity in pancreatic cancer cells using a chemoprevention gene therapy approachCRAdRGDflt-IL24 virotherapy in combination with chemotherapy of experimental glioma.Enhanced prostate cancer gene transfer and therapy using a novel serotype chimera cancer terminator virus (Ad.5/3-CTV).Targeting breast cancer-initiating/stem cells with melanoma differentiation-associated gene-7/interleukin-24.Chapter One---Cancer terminator viruses and approaches for enhancing therapeutic outcomes.Gene Therapies for Cancer: Strategies, Challenges and Successes.mda-7/IL-24: a unique member of the IL-10 gene family promoting cancer-targeted toxicity.mda-7/IL-24 differentially regulates soluble and nuclear clusterin in prostate cancer.mda-7/IL-24: multifunctional cancer-specific apoptosis-inducing cytokineMDA-7/IL-24 suppresses human ovarian carcinoma growth in vitro and in vivo.Strategy for reversing resistance to a single anticancer agent in human prostate and pancreatic carcinomasIL-2 regulates the expression of the tumor suppressor IL-24 in melanoma cells.MDA-7/IL-24: multifunctional cancer killing cytokineIonizing radiation enhances adenoviral vector expressing mda-7/IL-24-mediated apoptosis in human ovarian cancer.Suppression of Her2/Neu mammary tumor development in mda-7/IL-24 transgenic miceMelanoma differentiation associated gene-7/interleukin-24 (mda-7/IL-24): novel gene therapeutic for metastatic melanoma.Histone deacetylase inhibitors interact with melanoma differentiation associated-7/interleukin-24 to kill primary human glioblastoma cells.Selected approaches for rational drug design and high throughput screening to identify anti-cancer moleculesIL-24: a classic cytokine and/or a potential cure for cancer?
P2860
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P2860
mda-7/IL-24, a novel cancer selective apoptosis inducing cytokine gene: from the laboratory into the clinic
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2003 nî lūn-bûn
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2003 թուականին հրատարակուած գիտական յօդուած
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2003 թվականին հրատարակված գիտական հոդված
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2003年の論文
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2003年論文
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2003年論文
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mda-7/IL-24, a novel cancer se ...... the laboratory into the clinic
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mda-7/IL-24, a novel cancer se ...... the laboratory into the clinic
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mda-7/IL-24, a novel cancer se ...... the laboratory into the clinic
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mda-7/IL-24, a novel cancer se ...... the laboratory into the clinic
@ast
mda-7/IL-24, a novel cancer se ...... the laboratory into the clinic
@en
mda-7/IL-24, a novel cancer se ...... the laboratory into the clinic
@nl
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mda-7/IL-24, a novel cancer se ...... the laboratory into the clinic
@ast
mda-7/IL-24, a novel cancer se ...... the laboratory into the clinic
@en
mda-7/IL-24, a novel cancer se ...... the laboratory into the clinic
@nl
P2093
P1476
mda-7/IL-24, a novel cancer se ...... the laboratory into the clinic
@en
P2093
David T Curiel
Elizabeth A Grimm
Paul B Fisher
Rahul V Gopalkrishnan
Rajagopal Ramesh
Sunil Chada
P304
P407
P433
P577
2003-07-01T00:00:00Z