The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein
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Cyclic stretch stimulates vascular smooth muscle cell alignment by redox-dependent activation of Notch3Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE)ADAM 12 protease induces adipogenesis in transgenic miceα-Cleavage of cellular prion proteinShadoo/PrP (Sprn(0/0) /Prnp(0/0) ) double knockout mice: more than zeroesProtease resistant protein cellular isoform (PrP(c)) as a biomarker: clues into the pathogenesis of HANDCellular aspects of prion replication in vitroLoss of Cellular Sialidases Does Not Affect the Sialylation Status of the Prion Protein but Increases the Amounts of Its Proteolytic Fragment C1Alzheimer's disease and prion proteinProteolytic processing of Alzheimer's β-amyloid precursor proteinThe caspase 6 derived N-terminal fragment of DJ-1 promotes apoptosis via increased ROS productionPrion fragment peptides are digested with membrane type matrix metalloproteinases and acquire enzyme resistance through Cu²⁺-bindingCellular prion protein regulates beta-secretase cleavage of the Alzheimer's amyloid precursor protein.Effects of FlAsH/tetracysteine (TC) Tag on PrP proteolysis and PrPres formation by TC-scanning.The polybasic N-terminal region of the prion protein controls the physical properties of both the cellular and fibrillar forms of PrP.Unexpected tolerance of alpha-cleavage of the prion protein to sequence variationsThe biological function of the cellular prion protein: an updateEndogenous proteolytic cleavage of disease-associated prion protein to produce C2 fragments is strongly cell- and tissue-dependent.ADAM17 activity and other mechanisms of soluble L-selectin production during death receptor-induced leukocyte apoptosis.A functional role for ADAM10 in human immunodeficiency virus type-1 replicationThe N-terminal, polybasic region is critical for prion protein neuroprotective activity.L1 is sequentially processed by two differently activated metalloproteases and presenilin/gamma-secretase and regulates neural cell adhesion, cell migration, and neurite outgrowthTwo functionally distinct isoforms of TL1A (TNFSF15) generated by differential ectodomain sheddingPrP overdrive: does inhibition of α-cleavage contribute to PrP(C) toxicity and prion disease?The sheddase ADAM10 is a potent modulator of prion disease.Cytotoxic activity of immunotoxin SS1P is modulated by TACE-dependent mesothelin shedding.Octarepeat region flexibility impacts prion function, endoproteolysis and disease manifestationThe extracellular regulated kinase-1 (ERK1) controls regulated alpha-secretase-mediated processing, promoter transactivation, and mRNA levels of the cellular prion protein.Structural and mechanistic commonalities of amyloid-β and the prion proteinA naturally occurring C-terminal fragment of the prion protein (PrP) delays disease and acts as a dominant-negative inhibitor of PrPSc formation.The Prion Protein N1 and N2 Cleavage Fragments Bind to Phosphatidylserine and Phosphatidic Acid; Relevance to Stress-Protection ResponsesPrion protein at the crossroads of physiology and disease.α-Secretase-derived fragment of cellular prion, N1, protects against monomeric and oligomeric amyloid β (Aβ)-associated cell death.Inducible overexpression of wild-type prion protein in the muscles leads to a primary myopathy in transgenic mice.Prion infection of muscle cells in vitroTherapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie.Cellular prion protein regulates its own α-cleavage through ADAM8 in skeletal muscle.Lipid rafts and Alzheimer's disease: protein-lipid interactions and perturbation of signaling.PrPC Undergoes Basal to Apical Transcytosis in Polarized Epithelial MDCK CellsThe role of proteases in regulating Eph/ephrin signaling.
P2860
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P2860
The disintegrins ADAM10 and TACE contribute to the constitutive and phorbol ester-regulated normal cleavage of the cellular prion protein
description
2001 nî lūn-bûn
@nan
2001 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
name
The disintegrins ADAM10 and TA ...... of the cellular prion protein
@ast
The disintegrins ADAM10 and TA ...... of the cellular prion protein
@en
The disintegrins ADAM10 and TA ...... of the cellular prion protein
@nl
type
label
The disintegrins ADAM10 and TA ...... of the cellular prion protein
@ast
The disintegrins ADAM10 and TA ...... of the cellular prion protein
@en
The disintegrins ADAM10 and TA ...... of the cellular prion protein
@nl
prefLabel
The disintegrins ADAM10 and TA ...... of the cellular prion protein
@ast
The disintegrins ADAM10 and TA ...... of the cellular prion protein
@en
The disintegrins ADAM10 and TA ...... of the cellular prion protein
@nl
P2093
P356
P1476
The disintegrins ADAM10 and TA ...... of the cellular prion protein
@en
P2093
B De Strooper
D Hartmann
E Lopez-Perez
P304
P356
10.1074/JBC.M105677200
P407
P577
2001-10-12T00:00:00Z