Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
about
The thiazide-sensitive Na-Cl cotransporter is regulated by a WNK kinase signaling complexAntagonistic regulation of ROMK by long and kidney-specific WNK1 isoforms.Molecular physiology of the thiazide-sensitive sodium-chloride cotransporterThe thiazide-sensitive Na+-Cl- cotransporter: molecular biology, functional properties, and regulation by WNKsWNK3 and WNK4 amino-terminal domain defines their effect on the renal Na+-Cl- cotransporterWNK kinases, renal ion transport and hypertensionRegulation of ROMK channel and K+ homeostasis by kidney-specific WNK1 kinaseA molecular update on pseudohypoaldosteronism type IIA role for the circadian clock protein Per1 in the regulation of the NaCl co-transporter (NCC) and the with-no-lysine kinase (WNK) cascade in mouse distal convoluted tubule cellsA SPAK isoform switch modulates renal salt transport and blood pressureEmerging Targets of Diuretic Therapy.Polymorphisms in the WNK1 gene are associated with blood pressure variation and urinary potassium excretion.Mechanism of salt-sensitive hypertension: focus on adrenal and sympathetic nervous systemsDecreased ENaC expression compensates the increased NCC activity following inactivation of the kidney-specific isoform of WNK1 and prevents hypertension.WNK kinases and renal sodium transport in health and disease: an integrated view.Downregulation of NCC and NKCC2 cotransporters by kidney-specific WNK1 revealed by gene disruption and transgenic mouse modelsThe WNKs: atypical protein kinases with pleiotropic actions.WNK4-mediated regulation of renal ion transport proteins.WNK1 kinase isoform switch regulates renal potassium excretion.Recent advances in distal tubular potassium handlingInsulin resistance, obesity, hypertension, and renal sodium transport.Generation of WNK1 knockout cell lines by CRISPR/Cas-mediated genome editing.Cardiovascular expression of the mouse WNK1 gene during development and adulthood revealed by a BAC reporter assay.Genomic-derived markers for early detection of calcineurin inhibitor immunosuppressant-mediated nephrotoxicityOverexpression of the sodium chloride cotransporter is not sufficient to cause familial hyperkalemic hypertension.Alternatively spliced proline-rich cassettes link WNK1 to aldosterone actionKidney-specific WNK1 inhibits sodium reabsorption in the cortical thick ascending limbCell-specific regulation of L-WNK1 by dietary K.Interactions with WNK (with no lysine) family members regulate oxidative stress response 1 and ion co-transporter activityRegulation of the renal Na+-Cl- cotransporter by phosphorylation and ubiquitylation.Kidney-specific WNK1 regulates sodium reabsorption and potassium secretion in mouse cortical collecting duct.An unexpected journey: conceptual evolution of mechanoregulated potassium transport in the distal nephron.Multigene kinase network, kidney transport, and salt in essential hypertension.Effect of aldosterone on BK channel expression in mammalian cortical collecting duct.Hypertension: the missing WNKs.WNK4 diverts the thiazide-sensitive NaCl cotransporter to the lysosome and stimulates AP-3 interactionAldosterone mediates activation of the thiazide-sensitive Na-Cl cotransporter through an SGK1 and WNK4 signaling pathway.The ARH adaptor protein regulates endocytosis of the ROMK potassium secretory channel in mouse kidney.The WNK kinase network regulating sodium, potassium, and blood pressure.Aldosterone paradox: differential regulation of ion transport in distal nephron.
P2860
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P2860
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
description
2006 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
2006 թվականի մարտին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2006
@ast
im März 2006 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2006/03/01)
@sk
vědecký článek publikovaný v roce 2006
@cs
wetenschappelijk artikel (gepubliceerd op 2006/03/01)
@nl
наукова стаття, опублікована в березні 2006
@uk
مقالة علمية (نشرت في مارس 2006)
@ar
name
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
@ast
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
@en
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
@nl
type
label
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
@ast
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
@en
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
@nl
prefLabel
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
@ast
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
@en
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
@nl
P2093
P2860
P1476
Dominant-negative regulation of WNK1 by its kidney-specific kinase-defective isoform
@en
P2093
Arohan R Subramanya
Chao-Ling Yang
Xiaoman Zhu
P2860
P304
P356
10.1152/AJPRENAL.00280.2005
P577
2005-10-04T00:00:00Z