Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function - Wikidata - wikimedia - TriplyDB

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

http://www.wikidata.org/entity/Q35984381

about

A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein Calsenilin reverses presenilin-mediated enhancement of calcium signaling Calbindin-D28K dynamically controls TRPV5-mediated Ca2+ transport Mitochondrial release of caspase-2 and -9 during the apoptotic process Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation Evidence for the involvement of Par-4 in ischemic neuron cell death Multiplexed immunoassay panel identifies novel CSF biomarkers for Alzheimer's disease diagnosis and prognosis Mitochondrial Ca2+ overload underlies Abeta oligomers neurotoxicity providing an unexpected mechanism of neuroprotection by NSAIDs Calcium signaling and cytotoxicity.Ca(2+)-mediated mitochondrial dysfunction and the protective effects of Bcl-2.Cellular and molecular mechanisms underlying perturbed energy metabolism and neuronal degeneration in Alzheimer's and Parkinson's diseases.Mitochondrial dysfunction induced by different organochalchogens is mediated by thiol oxidation and is not dependent of the classical mitochondrial permeability transition pore opening.Crucial role of calbindin-D28k in the pathogenesis of Alzheimer's disease mouse model.Selective vulnerability of neurons in layer II of the entorhinal cortex during aging and Alzheimer's disease.Changes in transcript and protein levels of calbindin D28k, calretinin and parvalbumin, and numbers of neuronal populations expressing these proteins in an ischemia model of rat retina.Aberrant subcellular neuronal calcium regulation in aging and Alzheimer's disease Alzheimer's disease: role of aging in pathogenesis.Neurons bearing presenilins: weapons for defense or suicide?Cholinergic degeneration and memory loss delayed by vitamin E in a Down syndrome mouse model.Calcium dyshomeostasis and intracellular signalling in Alzheimer's disease.Vitamin D target proteins: function and regulation.Neuronal depletion of calcium-dependent proteins in the dentate gyrus is tightly linked to Alzheimer's disease-related cognitive deficits.Effects of blocking developmental cell death on sexually dimorphic calbindin cell groups in the preoptic area and bed nucleus of the stria terminalis.Oxidative Stress-Mediated Brain Dehydroepiandrosterone (DHEA) Formation in Alzheimer's Disease Diagnosis Neuronal amyloid-β accumulation within cholinergic basal forebrain in ageing and Alzheimer's disease.Identification of novel regulatory NFAT and TFII-I binding elements in the calbindin-D28k promoter in response to serum deprivation.Alzheimer's disease: A hypothesis on pathogenesis.Capacitative calcium entry deficits and elevated luminal calcium content in mutant presenilin-1 knockin mice Ageing and neuronal vulnerability.Focal cerebral ischemic injury decreases calbindin expression in brain tissue and HT22 cells.Numb-mediated neurite outgrowth is isoform-dependent, and requires activation of voltage-dependent calcium channels.Prevention of dementia by antihypertensive drugs: how AT1-receptor-blockers and dihydropyridines better prevent dementia in hypertensive patients than thiazides and ACE-inhibitors.Crosstalk between calcium, amyloid beta and the receptor for advanced glycation endproducts in Alzheimer's disease.Hippocampal pyramidal cells: the reemergence of cortical lamination.Proteome analysis associated with cadmium adaptation in U937 cells: identification of calbindin-D28k as a secondary cadmium-responsive protein that confers resistance to cadmium-induced apoptosis.Enhanced ROS generation mediated by Alzheimer's disease presenilin regulation of InsP3R Ca2+ signaling.Calbindin-D28k is expressed in osteoblastic cells and suppresses their apoptosis by inhibiting caspase-3 activity.Effect of Androsterone after Pilocarpine-induced Status Epilepticus in Mice Neuroprotective effects of ischemic preconditioning on hippocampal CA1 pyramidal neurons through maintaining calbindin D28k immunoreactivity following subsequent transient cerebral ischemia.Subfield and layer-specific depletion in calbindin-D28K, calretinin and parvalbumin immunoreactivity in the dentate gyrus of amyloid precursor protein/presenilin 1 transgenic mice.

P2860

Q22009982-A52CB9AF-C92C-48AC-BF22-4001E3A62B20 Q22254629-681FD1A9-0C1C-47BE-99B6-C82D05F62D33 Q24293026-814F45AE-9740-479D-8D01-AC3FE8CAF3B4 Q24676806-C2163E90-0E71-49D3-ACBE-A99F2CA2A21B Q28506810-AE2D7108-318E-4F95-923C-040197DAF5FA Q28569113-4DCF0B36-8EB2-4D22-8D9A-2D1825666D4B Q28740917-BCDC3C02-77A0-47ED-8B62-8778092B2753 Q33354062-50CD4D82-9972-4918-A112-DD379D4FAF91 Q33608775-E36D0AC4-42AB-4125-99B2-E958EE16F673 Q33836188-F81DC378-F673-46EC-99A5-FB12F424C7B8 Q33836230-DB9A9A5F-470F-4FEA-AD1F-AD36FFC141E2 Q34072010-AFA14F28-2C3C-496C-854A-113EB7B29C20 Q34153507-ACD02585-0FF5-499C-A660-43CEAF17DC0D Q34165442-9EB51FC7-7694-4547-BDEC-0C0BA67EF5EE Q34462321-F09D72FF-7D7B-4570-B465-AEE75041B727 Q34547754-96940369-53C8-42FC-A1E7-E9193726692C Q34614555-491F5EF2-462B-4530-88B0-1697B1A5A67A Q34687686-8E879A4D-428D-44DD-BDB9-799FBC645AF1 Q34918986-E4BBA886-95DF-4494-A605-81716E7008B8 Q34988301-20B98647-0137-4526-B7F6-A14AED481D7D Q35042177-782FD412-D59F-4F6E-AED4-938515FB224D Q35234934-2755B3C8-8FF2-45E3-A821-F8D3B4E42644 Q35834379-85F00323-5235-4F73-BE90-42F88678D9AE Q35972310-7E673769-9EF5-4F06-B500-2BF5AC3580F3 Q35974488-2F3F40B2-7FE0-4604-BF16-3BEA99AA6D0A Q36127029-DBB5E34F-2D01-4DB5-BF4D-159E282FB442 Q36271097-754F84CB-9746-494F-A7D0-A808C94F590F Q36327027-8D601994-C4B5-416C-BF5D-8C8A6F280B51 Q36428039-95DC51AB-84D5-4C90-8D0E-701A3B3C7AE1 Q37217334-65031FCC-4CCF-494C-8DAF-CDE38BE843C7 Q37218136-4E5BF685-B89E-452F-B23D-DF9F61BB0979 Q37600876-033DDB1B-A1A0-4CFE-A8CE-3AF672845687 Q37602130-480F4666-657E-4024-9850-F9BFA7A0275A Q37877604-8F4D8326-BBC3-45FF-BAB7-5B67C01D250F Q38517434-D98C5F40-48D4-4CFF-9C7F-B372077214FA Q39668678-6BACF30F-3BBB-4BA2-AE1C-093A31441635 Q40876368-86FC28BF-36DB-4A91-AFE0-503D6AB229E9 Q40995804-CD65F89B-082E-4B48-A2C7-F31917447E03 Q41043746-97B22D6F-7FA2-416C-B1CA-30A6883B0069 Q41149215-18B28240-A084-42DA-94DD-3BA1AC3314DD

P2860

Calbindin D28k blocks the proapoptotic actions of mutant presenilin 1: reduced oxidative stress and preserved mitochondrial function

http://www.wikidata.org/entity/Q35984381

description

1998 nî lūn-bûn

@nan

1998年の論文

@ja

1998年論文

@yue

1998年論文

@zh-hant

1998年論文

@zh-hk

1998年論文

@zh-mo

1998年論文

@zh-tw

1998年论文

@wuu

1998年论文

@zh

1998年论文

@zh-cn

name

Calbindin D28k blocks the proa ...... eserved mitochondrial function

@ast

Calbindin D28k blocks the proa ...... eserved mitochondrial function

@en

type

label

Calbindin D28k blocks the proa ...... eserved mitochondrial function

@ast

Calbindin D28k blocks the proa ...... eserved mitochondrial function

@en

prefLabel

Calbindin D28k blocks the proa ...... eserved mitochondrial function

@ast

Calbindin D28k blocks the proa ...... eserved mitochondrial function

@en

P1433

Q35984381-61BF9988-6494-462B-A149-935062ABFBFD

P1476

Q35984381-B9382B12-5046-4E40-B35B-59A31DE3B979

P2093

Q35984381-05988A39-6CF4-4AD4-8C27-2AB5886E7B0E

Q35984381-25C911A8-5D03-40B4-A189-31B36D3ED043

Q35984381-7DA98AD7-DB7D-4EA4-8258-1CB88BC92C79

Q35984381-A9E175DE-4CD8-4DA7-BBE9-F8B6A5FF22EC

P2860

Q35984381-00D3D97E-7A47-4CF9-B92F-9199D180C187

Q35984381-02484A04-CB90-4D98-8811-8CB0A146D148

Q35984381-02638ED3-602A-4780-8106-8BBD8F48D0C9

Q35984381-02658F7B-9094-4473-8C24-F092AC324F06

Q35984381-08F783CE-60D0-4EE6-A234-623F9F57B096

Q35984381-0C2B86B3-FA0A-4CB6-B9EF-DF0F423ACDD2

Q35984381-0DE2305B-F1F9-4764-BA02-6F55DD0DB895

Q35984381-10705CB3-4A18-4ECE-A84B-C0B25BA47B55

Q35984381-10FE5CA3-CA3E-42F4-96E1-E16362D1A9E0

Q35984381-116EA67E-787E-4484-94DD-8FF2FD378578

P304

Q35984381-6923C7D6-9C87-4E42-9837-DE917EE95470

P31

Q35984381-C1E51444-C001-4F1A-BC91-F5221703AEA6

P356

Q35984381-913AC96F-B02C-473E-B597-021D62B7A45B

P407

Q35984381-B5F104C8-7D0E-4841-B297-6866DF755211

P433

Q35984381-B1601F59-5668-45ED-99CF-C28ABF7831EE

P478

Q35984381-45CA932C-3056-47E9-A763-EB6C7BA2AC1B

P577

Q35984381-8B9077DE-0841-4CB8-BCA1-82FB881AE206

P5875

Q35984381-8F87C106-0A24-4590-870D-D2EBB3831156

P698

Q35984381-6FA11FCC-383F-43D7-881B-1CD57154556F

P932

Q35984381-3A9848D5-B34F-446A-B803-0A1481A42C5B

P356

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Calbindin D28k blocks the proa ...... eserved mitochondrial function

@en

P2093

M P Mattson

http://www.w3.org/2001/XMLSchema#string

N Robinson

http://www.w3.org/2001/XMLSchema#string

Q Guo

http://www.w3.org/2001/XMLSchema#string

S Christakos

http://www.w3.org/2001/XMLSchema#string

P2860

Correlative Memory Deficits, Abeta Elevation, and Amyloid Plaques in Transgenic Mice

Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease

Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays

A new generation of Ca2+ indicators with greatly improved fluorescence properties

Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1

Alternative cleavage of Alzheimer-associated presenilins during apoptosis by a caspase-3 family protease

Ultrastructural localization of calbindin-D28k and GABA in the matrix compartment of the rat caudate-putamen nuclei

Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease

Specific reduction of calcium-binding protein (28-kilodalton calbindin-D) gene expression in aging and neurodegenerative diseases.

Alzheimer-associated presenilins 1 and 2: neuronal expression in brain and localization to intracellular membranes in mammalian cells.

P304

3227-3232

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.95.6.3227

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

95

http://www.w3.org/2001/XMLSchema#string

P577

1998-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

51298960

http://www.w3.org/2001/XMLSchema#string

P698

9501245

http://www.w3.org/2001/XMLSchema#string

P932

19724

http://www.w3.org/2001/XMLSchema#string