Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation - Wikidata - wikimedia - TriplyDB

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

http://www.wikidata.org/entity/Q28250296

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SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1 PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1 Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interaction Pleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammation A third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activation The DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc Finger Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism Loss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1.Functional Aspects of PARP1 in DNA Repair and Transcription.Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure.Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma.Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells.Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases.Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation.The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response.Mechanism of anthracycline-mediated down-regulation of GATA4 in the heart PARP inhibition attenuates acute kidney allograft rejection by suppressing cell death pathways and activating PI-3K-Akt cascade.Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating protein Cross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factors Decitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemia The Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compounds Regulation of chromatin structure by poly(ADP-ribosyl)ation.Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemia Poly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cells Oncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy.Regulation of autophagy by nucleoporin Tpr.CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells.The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series.p53 regulation upon genotoxic stress: intricacies and complexities.Quantification of cellular poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamics PARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiation Repression of classical nuclear export by S-nitrosylation of CRM1.Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling.Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos.CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.Correlation between PARP-1 immunoreactivity and cytomorphological features of parthanatos, a specific cellular death in breast cancer cells.SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism.Regulation of p53--insights into a complex process.

P2860

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P2860

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

http://www.wikidata.org/entity/Q28250296

description

2007 nî lūn-bûn

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2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2007 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

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Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

@en

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

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type

label

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

@ast

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

@en

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

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prefLabel

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

@ast

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

@en

Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

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Nature Cell Biology

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Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation

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A Hamid Boulares

http://www.w3.org/2001/XMLSchema#string

Kazuhiko Hanashiro

http://www.w3.org/2001/XMLSchema#string

Kenji Fukasawa

http://www.w3.org/2001/XMLSchema#string

Masanao Miwa

http://www.w3.org/2001/XMLSchema#string

Masayuki Kanai

http://www.w3.org/2001/XMLSchema#string

Shuji Hanai

http://www.w3.org/2001/XMLSchema#string

Song-Hee Kim

http://www.w3.org/2001/XMLSchema#string

P2860

Mdm2 promotes the rapid degradation of p53

Regulation of p53 stability by Mdm2

Divorcing ARF and p53: an unsettled case

Poly(ADP-ribose) binds to specific domains of p53 and alters its DNA binding functions

Yama/CPP32 beta, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

C-terminal ubiquitination of p53 contributes to nuclear export

ATM-dependent telomere loss in aging human diploid fibroblasts and DNA damage lead to the post-translational activation of p53 protein involving poly(ADP-ribose) polymerase.

A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking.

Functions of poly(ADP-ribose) polymerase (PARP) in DNA repair, genomic integrity and cell death.

Poly(APD-ribosyl)ation, a DNA damage-driven protein modification and regulator of genomic instability.

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1175-83

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10.1038/NCB1638

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17891139

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