Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
about
SIRT1 promotes cell survival under stress by deacetylation-dependent deactivation of poly(ADP-ribose) polymerase 1PARP16/ARTD15 is a novel endoplasmic-reticulum-associated mono-ADP-ribosyltransferase that interacts with, and modifies karyopherin-ß1Nuclear translocation of p65 NF-kappaB is sufficient for VCAM-1, but not ICAM-1, expression in TNF-stimulated smooth muscle cells: Differential requirement for PARP-1 expression and interactionPleiotropic cellular functions of PARP1 in longevity and aging: genome maintenance meets inflammationA third zinc-binding domain of human poly(ADP-ribose) polymerase-1 coordinates DNA-dependent enzyme activationThe DNA-Binding Domain of Human PARP-1 Interacts with DNA Single-Strand Breaks as a Monomer through Its Second Zinc FingerDysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanismLoss of androgen receptor in aging and oxidative stress through Myb protooncoprotein-regulated reciprocal chromatin dynamics of p53 and poly(ADP-ribose) polymerase PARP-1.Functional Aspects of PARP1 in DNA Repair and Transcription.Arsenite induced poly(ADP-ribosyl)ation of tumor suppressor P53 in human skin keratinocytes as a possible mechanism for carcinogenesis associated with arsenic exposure.Selinexor Overcomes Hypoxia-Induced Drug Resistance in Multiple Myeloma.Novel small molecule XPO1/CRM1 inhibitors induce nuclear accumulation of TP53, phosphorylated MAPK and apoptosis in human melanoma cells.Clickable NAD analogues for labeling substrate proteins of poly(ADP-ribose) polymerases.Poly(ADP-ribose) polymerase-1 is a determining factor in Crm1-mediated nuclear export and retention of p65 NF-kappa B upon TLR4 stimulation.The level of Ets-1 protein is regulated by poly(ADP-ribose) polymerase-1 (PARP-1) in cancer cells to prevent DNA damage.The 3'-5' DNA exonuclease TREX1 directly interacts with poly(ADP-ribose) polymerase-1 (PARP1) during the DNA damage response.Mechanism of anthracycline-mediated down-regulation of GATA4 in the heartPARP inhibition attenuates acute kidney allograft rejection by suppressing cell death pathways and activating PI-3K-Akt cascade.Identification of poly (ADP-ribose) polymerase-1 (PARP-1) as a novel Kruppel-like factor 8-interacting and -regulating proteinCross-talk between distinct nuclear import pathways enables efficient nuclear import of E47 in conjunction with its partner transcription factorsDecitabine priming enhances the antileukemic effects of exportin 1 (XPO1) selective inhibitor selinexor in acute myeloid leukemiaThe Cellular Distribution of RanGAP1 Is Regulated by CRM1-Mediated Nuclear Export in Mammalian Cells.Deciphering mechanisms of drug sensitivity and resistance to Selective Inhibitor of Nuclear Export (SINE) compoundsRegulation of chromatin structure by poly(ADP-ribosyl)ation.Preclinical activity of a novel CRM1 inhibitor in acute myeloid leukemiaPoly(ADP-ribose) polymerase inhibitors activate the p53 signaling pathway in neural stem/progenitor cellsOncogenic role of p21 in hepatocarcinogenesis suggests a new treatment strategy.Regulation of autophagy by nucleoporin Tpr.CRM1 inhibitor S109 suppresses cell proliferation and induces cell cycle arrest in renal cancer cells.The expanding field of poly(ADP-ribosyl)ation reactions. 'Protein Modifications: Beyond the Usual Suspects' Review Series.p53 regulation upon genotoxic stress: intricacies and complexities.Quantification of cellular poly(ADP-ribosyl)ation by stable isotope dilution mass spectrometry reveals tissue- and drug-dependent stress response dynamicsPARP1 poly(ADP-ribosyl)ates Sox2 to control Sox2 protein levels and FGF4 expression during embryonic stem cell differentiationRepression of classical nuclear export by S-nitrosylation of CRM1.Thioredoxin-interacting protein mediates nuclear-to-plasma membrane communication: role in vascular endothelial growth factor 2 signaling.Poly(ADP-ribose) signals to mitochondrial AIF: a key event in parthanatos.CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.Correlation between PARP-1 immunoreactivity and cytomorphological features of parthanatos, a specific cellular death in breast cancer cells.SIRT1/PARP1 crosstalk: connecting DNA damage and metabolism.Regulation of p53--insights into a complex process.
P2860
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P2860
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
description
2007 nî lūn-bûn
@nan
2007 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
@ast
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
@en
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
@nl
type
label
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
@ast
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
@en
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
@nl
prefLabel
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
@ast
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
@en
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
@nl
P2093
P2860
P356
P1433
P1476
Inhibition of Crm1-p53 interaction and nuclear export of p53 by poly(ADP-ribosyl)ation
@en
P2093
A Hamid Boulares
Kazuhiko Hanashiro
Kenji Fukasawa
Masanao Miwa
Masayuki Kanai
Shuji Hanai
Song-Hee Kim
P2860
P2888
P304
P356
10.1038/NCB1638
P407
P577
2007-10-01T00:00:00Z
P6179
1026240654