Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity

Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity

Item
http://www.wikidata.org/entity/Q28256875
The FAM3 superfamily member ILEI ameliorates Alzheimer's disease-like pathology by destabilizing the penultimate amyloid-β precursor.Lipopolysaccharide-induced Notch signaling activation through JNK-dependent pathway regulates inflammatory response.The GxxxG motif in the transmembrane domain of AbetaPP plays an essential role in the interaction of CTF beta with the gamma-secretase complex and the formation of amyloid-betaInhibition of γ-Secretase Leads to an Increase in Presenilin-1.Amyloid precursor protein and endosomal-lysosomal dysfunction in Alzheimer's disease: inseparable partners in a multifactorial disease.gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain.Amyloidogenic processing but not amyloid precursor protein (APP) intracellular C-terminal domain production requires a precisely oriented APP dimer assembled by transmembrane GXXXG motifs.
P2860

Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently of gamma-secretase activity

Item
http://www.wikidata.org/entity/Q28256875
description
2004 nî lūn-bûn
@nan
2004 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Presenilin 1 stabilizes the C- ...... ly of gamma-secretase activity
@ast
Presenilin 1 stabilizes the C- ...... ly of gamma-secretase activity
@en
Presenilin 1 stabilizes the C- ...... ly of gamma-secretase activity
@nl
type
label
Presenilin 1 stabilizes the C- ...... ly of gamma-secretase activity
@ast
Presenilin 1 stabilizes the C- ...... ly of gamma-secretase activity
@en
Presenilin 1 stabilizes the C- ...... ly of gamma-secretase activity
@nl
prefLabel
Presenilin 1 stabilizes the C- ...... ly of gamma-secretase activity
@ast
Presenilin 1 stabilizes the C- ...... ly of gamma-secretase activity
@en
Presenilin 1 stabilizes the C- ...... ly of gamma-secretase activity
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698
P356
P1433
P1476
Presenilin 1 stabilizes the C- ...... ly of gamma-secretase activity
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P577
P5875
P698