Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase
about
Structural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analoguesExtending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinaseFunctional studies of active-site mutants from Drosophila melanogaster deoxyribonucleoside kinase. Investigations of the putative catalytic glutamate-arginine pair and of residues responsible for substrate specificityStructural studies of nucleoside analog and feedback inhibitor binding to Drosophila melanogaster multisubstrate deoxyribonucleoside kinasePhosphodeoxyribosyltransferases, Designed Enzymes for Deoxyribonucleotides SynthesisFunctional expression of a multisubstrate deoxyribonucleoside kinase from Drosophila melanogaster and its C-terminal deletion mutantsThymidine kinase 1 regulatory fine-tuning through tetramer formationDeoxynucleoside kinases encoded by the yaaG and yaaF genes of Bacillus subtilis. Substrate specificity and kinetic analysis of deoxyguanosine kinase with UTP as the preferred phosphate donor.Deoxynucleoside Salvage in Fission Yeast Allows Rescue of Ribonucleotide Reductase Deficiency but Not Spd1-Mediated Inhibition of Replication.Inherited mitochondrial DNA depletion.Enhancing nucleotide metabolism protects against mitochondrial dysfunction and neurodegeneration in a PINK1 model of Parkinson's diseaseTomato thymidine kinase-based suicide gene therapy for malignant glioma--an alternative for Herpes Simplex virus-1 thymidine kinase.Long term expression of Drosophila melanogaster nucleoside kinase in thymidine kinase 2-deficient mice with no lethal effects caused by nucleotide pool imbalances.Nucleoside analogues are activated by bacterial deoxyribonucleoside kinases in a species-specific manner.Reconstitution of an efficient thymidine salvage pathway in Saccharomyces cerevisiaeBiological phosphorylation of an Unnatural Base Pair (UBP) using a Drosophila melanogaster deoxynucleoside kinase (DmdNK) mutant.Case study on the evolution of hetero-oligomer interfaces based on the differences in paralogous proteins.Quantitative Detection of Nucleoside Analogues by Multi-enzyme Biosensors using Time-Resolved Kinetic Measurements.Directed evolution of an orthogonal nucleoside analog kinase via fluorescence-activated cell sorting.Development of gene therapy in association with clinically used cytotoxic deoxynucleoside analogues.Enzymatic regulation of cytosolic thymidine kinase 1 and mitochondrial thymidine kinase 2: a mini review.Enzymes to die for: exploiting nucleotide metabolizing enzymes for cancer gene therapy.Isolation of a novel protein, P12-from adult Drosophila melanogaster that inhibits deoxyribonucleoside and protein kinase activities and activates 3'-5'- exonuclease activity.Pyrimidine metabolism in schistosomes: A comparison with other parasites and the search for potential chemotherapeutic targets.A few amino acid substitutions can convert deoxyribonucleoside kinase specificity from pyrimidines to purines.Mosquito has a single multisubstrate deoxyribonucleoside kinase characterized by unique substrate specificity.Structural basis for the changed substrate specificity of Drosophila melanogaster deoxyribonucleoside kinase mutant N64D.Expression of tomato thymidine kinase 1 by means of the baculovirus expression vector system.Retroviral transduction of cancer cell lines with the gene encoding Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.Novel deoxynucleoside-phosphorylating enzymes in mycoplasmas: evidence for efficient utilization of deoxynucleosides.Transgene expression of Drosophila melanogaster nucleoside kinase reverses mitochondrial thymidine kinase 2 deficiency.Kinetic properties of mutant human thymidine kinase 2 suggest a mechanism for mitochondrial DNA depletion myopathy.Striking ability of adenosine-2'(3')-deoxy-3'(2')-triphosphates and related analogues to replace ATP as phosphate donor for all four human, and the Drosophila melanogaster, deoxyribonucleoside kinases.Active site mutants of Drosophila melanogaster multisubstrate deoxyribonucleoside kinase.Ability of adenosine-2'(3')-deoxy-3'(2')-triphosphates and related analogues to replace ATP as phosphate donor for all human and Drosphila melanogaster deoxyribonucleoside kinases.Transient expression of Drosophila melanogaster deoxynucleoside kinase gene enhances cytotoxicity of nucleoside analogs.Cloning and characterization of the multisubstrate deoxyribonucleoside kinase of Drosophila melanogaster.Quantification and tracking of genetically engineered dendritic cells for studying immunotherapy.Gene duplications and losses among vertebrate deoxyribonucleoside kinases of the non-TK1 Family.Animal deoxyribonucleoside kinases: 'forward' and 'retrograde' evolution of their substrate specificity.
P2860
Q24629752-B9A85C9A-41EF-41C3-A4FD-69445B90D506Q24658022-AEF6782E-1CA6-4F19-861F-94D9EBB3F05DQ27643825-763F1523-1FC0-455E-8808-ECF842B27D78Q27650210-4933FFF9-2C60-4B6B-9EB1-7D06D29B9F9BQ27675921-C81104C7-A2ED-4287-AB72-651AF3D797C5Q28145529-A081CB67-B516-4F59-8727-614A471F454EQ28570313-B052491C-0F1E-40C5-B72D-8ECFADE35C6DQ31567716-E2C84F00-9E52-46FA-AD2D-C1D1C8A9D9F1Q33737433-2E9E7D10-83DF-47D3-A021-4DE71BB00FAEQ34195471-79C52A6A-D15A-4056-B9C4-59B0F8A7844FQ34348591-796D711C-EA11-4397-AC71-B738FCCAD816Q34459264-919218D4-FB15-42C7-813B-9EFFA81937DCQ34552728-C513CB25-21EE-4A76-8114-772F857B4C55Q34646743-1C91A3E5-2FE5-4A63-8B47-91A85BFA1820Q36119806-DB3FC975-90B2-439D-A519-E41BF71F3C6DQ36316585-F7CCFA0C-1197-4013-9DD1-5270D6C4DC20Q36531711-104CA088-1870-4AA7-A687-C73862619714Q37080484-CA55DC9B-8BA9-4BA8-9B0A-BCFCB84A9A47Q37273666-F27581DF-5F96-4745-992F-0D7F0618650BQ37431500-07D5CFF8-E16C-4F7F-9342-F877BF31A6A9Q37764763-06CA90BE-2A28-444E-8CC3-DFB45937FAA1Q37989984-12EF3598-2B09-4895-8FFD-95546205C1DCQ38728086-A3F6A0EB-763B-48C5-A64D-6DD4336BBF15Q39453006-69B579EE-97FD-4EE9-A432-A5EC1D58EC00Q39646944-488DB565-AE5E-4281-941F-20950EDB5F1AQ39744692-EC2077CE-01B6-41C6-B7B7-B012B575E30BQ40406646-D7B026C9-9251-4FE6-8D21-C9A1F5E72BABQ40446843-7EC6A286-5BEC-4C2E-AB72-678D58B05175Q40854445-C0C0CF11-9E81-4454-BD34-5FA20F5E273AQ42665172-FEF73CBA-1DA2-4F89-B0BD-70024209A3E6Q43244825-A928111E-C0D7-4229-AC60-519D0DB1FC6DQ44257239-07709087-BAF6-498F-B522-9FEA9CF829B9Q44439369-DA9D453A-465E-4F49-BD73-5C0C7943CC05Q44489249-FA900056-68AE-41EF-9F26-100FE08E97DBQ44622290-15B2B72E-012F-41B3-9E9D-BD681CFA7E96Q45861091-2A2CFA1B-1524-448A-8654-EAD2C5D0C050Q47072801-ADC41476-F6C7-438E-B2E2-BE85044E32A4Q48556437-396F0B33-6CED-474B-81FA-FE560784B950Q51292799-7AB3E720-3D5D-4AEB-B843-638AF8189EB1Q52646101-B458088E-FEEB-4B7B-89EB-89C3F5474AFD
P2860
Four deoxynucleoside kinase activities from Drosophila melanogaster are contained within a single monomeric enzyme, a new multifunctional deoxynucleoside kinase
description
1998 nî lūn-bûn
@nan
1998 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Four deoxynucleoside kinase ac ...... ctional deoxynucleoside kinase
@ast
Four deoxynucleoside kinase ac ...... ctional deoxynucleoside kinase
@en
Four deoxynucleoside kinase ac ...... ctional deoxynucleoside kinase
@nl
type
label
Four deoxynucleoside kinase ac ...... ctional deoxynucleoside kinase
@ast
Four deoxynucleoside kinase ac ...... ctional deoxynucleoside kinase
@en
Four deoxynucleoside kinase ac ...... ctional deoxynucleoside kinase
@nl
prefLabel
Four deoxynucleoside kinase ac ...... ctional deoxynucleoside kinase
@ast
Four deoxynucleoside kinase ac ...... ctional deoxynucleoside kinase
@en
Four deoxynucleoside kinase ac ...... ctional deoxynucleoside kinase
@nl
P2093
P2860
P356
P1476
Four deoxynucleoside kinase ac ...... ctional deoxynucleoside kinase
@en
P2093
B Munch-Petersen
L Sondergaard
P2860
P304
P356
10.1074/JBC.273.7.3926
P407
P577
1998-02-13T00:00:00Z