Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase

Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase

Item
http://www.wikidata.org/entity/Q24658022
The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analoguesPost-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and releaseStructural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analoguesProdrug applications for targeted cancer therapy.Quantitative proteomic analysis reveals the perturbation of multiple cellular pathways in jurkat-T cells induced by doxorubicinRedesigning human 2'-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomographyStructure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.Cell fate control gene therapy based on engineered variants of human deoxycytidine kinaseCandidate genes contributing to the aggressive phenotype of mantle cell lymphoma.Long-term in vivo monitoring of mouse and human hematopoietic stem cell engraftment with a human positron emission tomography reporter gene.Application of a rapid, simple, and accurate adenovirus-based method to compare PET reporter gene/PET reporter probe systems.Enzymes to die for: exploiting nucleotide metabolizing enzymes for cancer gene therapy.New insights into the synergism of nucleoside analogs with radiotherapySelective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells.Understanding the role of structural integrity and differential expression of integrin profiling to identify potential therapeutic targets in breast cancer.Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer.A new pyrimidine-specific reporter gene: a mutated human deoxycytidine kinase suitable for PET during treatment with acycloguanosine-based cytotoxic drugs.
P2860

Extending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinase

Item
http://www.wikidata.org/entity/Q24658022
description
2009 nî lūn-bûn
@nan
2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Extending thymidine kinase act ...... of human deoxycytidine kinase
@ast
Extending thymidine kinase act ...... of human deoxycytidine kinase
@en
Extending thymidine kinase act ...... of human deoxycytidine kinase
@nl
type
label
Extending thymidine kinase act ...... of human deoxycytidine kinase
@ast
Extending thymidine kinase act ...... of human deoxycytidine kinase
@en
Extending thymidine kinase act ...... of human deoxycytidine kinase
@nl
altLabel
Extending Thymidine Kinase Act ...... Human Deoxycytidine Kinase † ‡
@en
prefLabel
Extending thymidine kinase act ...... of human deoxycytidine kinase
@ast
Extending thymidine kinase act ...... of human deoxycytidine kinase
@en
Extending thymidine kinase act ...... of human deoxycytidine kinase
@nl
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932
P356
P1433
P1476
Extending thymidine kinase act ...... of human deoxycytidine kinase
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P5875
P698
P932