Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1
about
Phosphorylation of WASP by the Cdc42-associated kinase ACK1: dual hydroxyamino acid specificity in a tyrosine kinaseTrans-activation of the DNA-damage signalling protein kinase Chk2 by T-loop exchangeShepherding AKT and androgen receptor by Ack1 tyrosine kinaseConstitutive activated Cdc42-associated kinase (Ack) phosphorylation at arrested endocytic clathrin-coated pits of cells that lack dynaminAck1: Activation and Regulation by AllosteryOncogenic RET Kinase Domain Mutations Perturb the Autophosphorylation Trajectory by Enhancing Substrate Presentation In transACK1 tyrosine kinase: targeted inhibition to block cancer cell proliferationConservation, variability and the modeling of active protein kinasesThe Cdc42-associated kinase ACK1 is not autoinhibited but requires Src for activation.Cancer-associated mutations activate the nonreceptor tyrosine kinase Ack1.The phosphotyrosine peptide binding specificity of Nck1 and Nck2 Src homology 2 domains.High-throughput kinase profiling: a more efficient approach toward the discovery of new kinase inhibitors.Structure-function correlation of G6, a novel small molecule inhibitor of Jak2: indispensability of the stilbenoid core.Mutational analysis of the tyrosine kinome in serous and clear cell endometrial cancer uncovers rare somatic mutations in TNK2 and DDR1Regulation of ack-family nonreceptor tyrosine kinases.Conserved tyrosine kinase promotes the import of silencing RNA into Caenorhabditis elegans cells.Small-molecule inhibitors binding to protein kinases. Part I: exceptions from the traditional pharmacophore approach of type I inhibition.RET Functions as a Dual-Specificity Kinase that Requires Allosteric Inputs from Juxtamembrane Elements.Phosphorylation State-Dependent High Throughput Screening of the c-Met Kinase.Automating crystallographic structure solution and refinement of protein-ligand complexes.Down-regulation of active ACK1 is mediated by association with the E3 ubiquitin ligase Nedd4-2.Cytoplasmic ACK1 interaction with multiple receptor tyrosine kinases is mediated by Grb2: an analysis of ACK1 effects on Axl signaling.The human kinome and kinase inhibition.Identification of novel Ack1-interacting proteins and Ack1 phosphorylated sites in mouse brain by mass spectrometry.Effects of ligand binding upon flexibility of proteins.
P2860
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P2860
Crystal structures of the phosphorylated and unphosphorylated kinase domains of the Cdc42-associated tyrosine kinase ACK1
description
2004 nî lūn-bûn
@nan
2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
2004 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
2004年の論文
@ja
2004年論文
@yue
2004年論文
@zh-hant
2004年論文
@zh-hk
2004年論文
@zh-mo
2004年論文
@zh-tw
2004年论文
@wuu
name
Crystal structures of the phos ...... ssociated tyrosine kinase ACK1
@ast
Crystal structures of the phos ...... ssociated tyrosine kinase ACK1
@en
Crystal structures of the phos ...... ssociated tyrosine kinase ACK1
@nl
type
label
Crystal structures of the phos ...... ssociated tyrosine kinase ACK1
@ast
Crystal structures of the phos ...... ssociated tyrosine kinase ACK1
@en
Crystal structures of the phos ...... ssociated tyrosine kinase ACK1
@nl
prefLabel
Crystal structures of the phos ...... ssociated tyrosine kinase ACK1
@ast
Crystal structures of the phos ...... ssociated tyrosine kinase ACK1
@en
Crystal structures of the phos ...... ssociated tyrosine kinase ACK1
@nl
P2093
P356
P1476
Crystal structures of the phos ...... ssociated tyrosine kinase ACK1
@en
P2093
Julie C Lougheed
Rui-Hong Chen
P304
44039-44045
P356
10.1074/JBC.M406703200
P407
P50
P577
2004-08-11T00:00:00Z