Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786
about
Essential role of insulin receptor substrate-2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytesCloning and characterization of PHIP, a novel insulin receptor substrate-1 pleckstrin homology domain interacting proteinInsulin stimulates PKCzeta -mediated phosphorylation of insulin receptor substrate-1 (IRS-1). A self-attenuated mechanism to negatively regulate the function of IRS proteinsTumor suppressor RBM5 directly interacts with the DExD/H-box protein DHX15 and stimulates its helicase activitySequence-specific recognition of the internalization motif of the Alzheimer's amyloid precursor protein by the X11 PTB domainDirect interaction of nerve growth factor receptor, TrkA, with non-receptor tyrosine kinase, c-Abl, through the activation loopTyr624 and Tyr628 in insulin receptor substrate-2 mediate its association with the insulin receptorInterplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth factor-I receptor-mediated signal transductionInteraction of the phosphotyrosine interaction/phosphotyrosine binding-related domains of Fe65 with wild-type and mutant Alzheimer's beta-amyloid precursor proteinsIdentification of the rat adapter Grb14 as an inhibitor of insulin actionsSuppressor of cytokine signaling 1 (SOCS-1) and SOCS-3 cause insulin resistance through inhibition of tyrosine phosphorylation of insulin receptor substrate proteins by discrete mechanismsSurfing the insulin signaling webA molecular basis for insulin resistance. Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphoryEffect of receptor phosphorylation on the binding between IRS-1 and IGF-1R as revealed by surface plasmon resonance biosensorCrystal structure of the activated insulin receptor tyrosine kinase in complex with peptide substrate and ATP analogIdentification of Stat 5B as a substrate of the insulin receptor.Insulin receptor substrates (IRSs) and breast tumorigenesis.Distinct recruitment and function of Gab1 and Gab2 in Met receptor-mediated epithelial morphogenesis.Insulin receptor substrate 2-mediated phosphatidylinositol 3-kinase signaling selectively inhibits glycogen synthase kinase 3β to regulate aerobic glycolysis.Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential.Insulin receptor substrate polymorphisms and type 2 diabetes mellitus.Molecular mechanism of insulin resistance in type 2 diabetes mellitus: role of the insulin receptor variant forms.Pdx1 restores beta cell function in Irs2 knockout mice.Adaptive responses to dasatinib-treated lung squamous cell cancer cells harboring DDR2 mutations.Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus.Regulating insulin signaling and beta-cell function through IRS proteins.The insulin receptor: both a prototypical and atypical receptor tyrosine kinase.High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motifThe phosphotyrosine interactome of the insulin receptor family and its substrates IRS-1 and IRS-2.Phosphorylation of IRS proteins, insulin action, and insulin resistance.Expression and function of the insulin receptor substrate proteins in cancerSerine phosphorylation proximal to its phosphotyrosine binding domain inhibits insulin receptor substrate 1 function and promotes insulin resistance.IRS-2 Partially Compensates for the Insulin Signal Defects in IRS-1-/- Mice Mediated by miR-33.Insulin signaling meets mitochondria in metabolism.Depletion of insulin receptor substrate 2 reverses oncogenic transformation induced by v-src.Targeting type 2 diabetes: lessons from a knockout model of insulin receptor substrate 2.CSF-1 receptor/insulin receptor chimera permits CSF-1-dependent differentiation of 3T3-L1 preadipocytes.Grb10 inhibits insulin-stimulated insulin receptor substrate (IRS)-phosphatidylinositol 3-kinase/Akt signaling pathway by disrupting the association of IRS-1/IRS-2 with the insulin receptor.The type 2 vascular endothelial growth factor receptor recruits insulin receptor substrate-1 in its signalling pathway.Differential activation of insulin receptor substrates 1 and 2 by insulin-like growth factor-activated insulin receptors.
P2860
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P2860
Insulin receptor substrate-2 binds to the insulin receptor through its phosphotyrosine-binding domain and through a newly identified domain comprising amino acids 591-786
description
1996 nî lūn-bûn
@nan
1996 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի մարտին հրատարակված գիտական հոդված
@hy
1996年の論文
@ja
1996年論文
@yue
1996年論文
@zh-hant
1996年論文
@zh-hk
1996年論文
@zh-mo
1996年論文
@zh-tw
1996年论文
@wuu
name
Insulin receptor substrate-2 b ...... comprising amino acids 591-786
@ast
Insulin receptor substrate-2 b ...... comprising amino acids 591-786
@en
Insulin receptor substrate-2 b ...... comprising amino acids 591-786
@nl
type
label
Insulin receptor substrate-2 b ...... comprising amino acids 591-786
@ast
Insulin receptor substrate-2 b ...... comprising amino acids 591-786
@en
Insulin receptor substrate-2 b ...... comprising amino acids 591-786
@nl
prefLabel
Insulin receptor substrate-2 b ...... comprising amino acids 591-786
@ast
Insulin receptor substrate-2 b ...... comprising amino acids 591-786
@en
Insulin receptor substrate-2 b ...... comprising amino acids 591-786
@nl
P2093
P3181
P356
P1476
Insulin receptor substrate-2 b ...... comprising amino acids 591-786
@en
P2093
D Sawka-Verhelle
E Van Obberghen
S Tartare-Deckert
P304
P3181
P356
10.1074/JBC.271.11.5980
P407
P577
1996-03-15T00:00:00Z