Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs
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Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acidsStructural Basis for the Role of the K65R Mutation in HIV-1 Reverse Transcriptase Polymerization, Excision Antagonism, and Tenofovir ResistanceMechanistic differences in RNA-dependent DNA polymerization and fidelity between murine leukemia virus and HIV-1 reverse transcriptasesAntiviral L-nucleosides specific for hepatitis B virus infectionMechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidineMetabolism of 2',3'-dideoxy-2',3'-didehydro-beta-L(-)-5-fluorocytidine and its activity in combination with clinically approved anti-human immunodeficiency virus beta-D(+) nucleoside analogs in vitroSynthesis and antiviral evaluation of the beta-L-enantiomers of some thymine 3'-deoxypentofuranonucleoside derivatives.The enantioselectivity of enzymes involved in current antiviral therapy using nucleoside analogues: a new strategy?Pharmacokinetics of beta-L-2',3'-dideoxy-5-fluorocytidine in rhesus monkeysPotentiation of inhibition of wild-type and mutant human immunodeficiency virus type 1 reverse transcriptases by combinations of nonnucleoside inhibitors and d- and L-(beta)-dideoxynucleoside triphosphate analogs.Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry.Mechanisms of nucleoside analog antiviral activity and resistance during human immunodeficiency virus reverse transcriptionAntiviral therapy for human immunodeficiency virus infectionsProbing the mechanistic consequences of 5-fluorine substitution on cytidine nucleotide analogue incorporation by HIV-1 reverse transcriptase.Molecular impact of the M184V mutation in human immunodeficiency virus type 1 reverse transcriptase.Endogenous reverse transcription assays reveal high-level resistance to the triphosphate of (-)2'-dideoxy-3'-thiacytidine by mutated M184V human immunodeficiency virus type 1A novel Met-to-Thr mutation in the YMDD motif of reverse transcriptase from feline immunodeficiency virus confers resistance to oxathiolane nucleosidesSuppression of viremia and evolution of human immunodeficiency virus type 1 drug resistance in a macaque model for antiretroviral therapy.TAR-RNA binding by HIV-1 Tat protein is selectively inhibited by its L-enantiomer.Human immunodeficiency virus type-1 reverse transcriptase. Contribution of Met-184 to binding of nucleoside 5'-triphosphate.Synthesis and biological evaluation of 9-(beta-L-arabinofuranosyl)adenine.Antiviral activity and intracellular metabolism of bis(tButylSATE) phosphotriester of beta-L-2',3'dideoxyadenosine, a potent inhibitor of HIV and HBV replication.Dioxolane guanosine 5'-triphosphate, an alternative substrate inhibitor of wild-type and mutant HIV-1 reverse transcriptase. Steady state and pre-steady state kinetic analyses.Molecular basis for the antiviral and anticancer activities of unnatural L-beta-nucleosides.Effects of non-nucleoside inhibitors of human immunodeficiency virus type 1 in cell-free recombinant reverse transcriptase assays.
P2860
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P2860
Inhibition of human immunodeficiency virus type 1 reverse transcriptase by the 5'-triphosphate beta enantiomers of cytidine analogs
description
1994 nî lūn-bûn
@nan
1994 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հոտեմբերին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Inhibition of human immunodefi ...... nantiomers of cytidine analogs
@ast
Inhibition of human immunodefi ...... nantiomers of cytidine analogs
@en
Inhibition of human immunodefi ...... nantiomers of cytidine analogs
@nl
type
label
Inhibition of human immunodefi ...... nantiomers of cytidine analogs
@ast
Inhibition of human immunodefi ...... nantiomers of cytidine analogs
@en
Inhibition of human immunodefi ...... nantiomers of cytidine analogs
@nl
prefLabel
Inhibition of human immunodefi ...... nantiomers of cytidine analogs
@ast
Inhibition of human immunodefi ...... nantiomers of cytidine analogs
@en
Inhibition of human immunodefi ...... nantiomers of cytidine analogs
@nl
P2093
P2860
P356
P1476
Inhibition of human immunodefi ...... nantiomers of cytidine analogs
@en
P2093
C D Morrow
G Gosselin
J K Wakefield
J L Imbach
J P Sommadossi
R F Schinazi
S McPherson
P2860
P304
P356
10.1128/AAC.38.10.2300
P407
P577
1994-10-01T00:00:00Z