Human immunodeficiency virus type-1 reverse transcriptase. Contribution of Met-184 to binding of nucleoside 5'-triphosphate.
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Lamivudine (3TC) resistance in HIV-1 reverse transcriptase involves steric hindrance with beta-branched amino acidsA new point mutation (P157S) in the reverse transcriptase of human immunodeficiency virus type 1 confers low-level resistance to (-)-beta-2',3'-dideoxy-3'-thiacytidineMechanistic characterization and molecular modeling of hepatitis B virus polymerase resistance to entecavirA novel point mutation at position 156 of reverse transcriptase from feline immunodeficiency virus confers resistance to the combination of (-)-beta-2',3'-dideoxy-3'-thiacytidine and 3'-azido-3'-deoxythymidineIncreased misincorporation fidelity observed for nucleoside analog resistance mutations M184V and E89G in human immunodeficiency virus type 1 reverse transcriptase does not correlate with the overall error rate measured in vitroWild-type and YMDD mutant murine leukemia virus reverse transcriptases are resistant to 2',3'-dideoxy-3'-thiacytidineYADD mutants of human immunodeficiency virus type 1 and Moloney murine leukemia virus reverse transcriptase are resistant to lamivudine triphosphate (3TCTP) in vitro.The enantioselectivity of enzymes involved in current antiviral therapy using nucleoside analogues: a new strategy?Nucleotide substitutions within U5 are critical for efficient reverse transcription of human immunodeficiency virus type 1 with a primer binding site complementary to tRNA(His)Retrovirus reverse transcriptases containing a modified YXDD motif.Emtricitabine, a new antiretroviral agent with activity against HIV and hepatitis B virus.Biochemical mechanism of HIV-1 resistance to rilpivirine.Apparent defects in processive DNA synthesis, strand transfer, and primer elongation of Met-184 mutants of HIV-1 reverse transcriptase derive solely from a dNTP utilization defect.Clinical significance of HIV reverse-transcriptase inhibitor-resistance mutations.The lysine 65 residue in HIV-1 reverse transcriptase function and in nucleoside analog drug resistance.The glutamine side chain at position 91 on the β5a-β5b loop of human immunodeficiency virus type 1 reverse transcriptase is required for stabilizing the dNTP binding pocket.Biophysical and enzymatic properties of the simian and prototype foamy virus reverse transcriptasesMolecular mechanisms of resistance to human immunodeficiency virus type 1 with reverse transcriptase mutations K65R and K65R+M184V and their effects on enzyme function and viral replication capacity.Mispair extension fidelity of human immunodeficiency virus type 1 reverse transcriptases with amino acid substitutions affecting Tyr115.A role of template cleavage in reduced excision of chain-terminating nucleotides by human immunodeficiency virus type 1 reverse transcriptase containing the M184V mutation.The L74V mutation in human immunodeficiency virus type 1 reverse transcriptase counteracts enhanced excision of zidovudine monophosphate associated with thymidine analog resistance mutations.The emergence of different resistance mechanisms toward nucleoside inhibitors is explained by the properties of the wild type HIV-1 reverse transcriptase.Site-specific incorporation of nucleoside analogs by HIV-1 reverse transcriptase and the template grip mutant P157S. Template interactions influence substrate recognition at the polymerase active site.Coupling ribose selection to fidelity of DNA synthesis. The role of Tyr-115 of human immunodeficiency virus type 1 reverse transcriptase.Anti-human immunodeficiency virus drug combination strategies.The balance between NRTI discrimination and excision drives the susceptibility of HIV-1 RT mutants K65R, M184V and K65r+M184V.Virologic and enzymatic studies revealing the mechanism of K65R- and Q151M-associated HIV-1 drug resistance towards emtricitabine and lamivudine.Twenty-Five Years of Lamivudine: Current and Future Use for the Treatment of HIV-1 Infection.
P2860
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P2860
Human immunodeficiency virus type-1 reverse transcriptase. Contribution of Met-184 to binding of nucleoside 5'-triphosphate.
description
1996 nî lūn-bûn
@nan
1996年の論文
@ja
1996年学术文章
@wuu
1996年学术文章
@zh-cn
1996年学术文章
@zh-hans
1996年学术文章
@zh-my
1996年学术文章
@zh-sg
1996年學術文章
@yue
1996年學術文章
@zh
1996年學術文章
@zh-hant
name
Human immunodeficiency virus t ...... of nucleoside 5'-triphosphate.
@en
type
label
Human immunodeficiency virus t ...... of nucleoside 5'-triphosphate.
@en
prefLabel
Human immunodeficiency virus t ...... of nucleoside 5'-triphosphate.
@en
P2093
P2860
P356
P1476
Human immunodeficiency virus t ...... of nucleoside 5'-triphosphate.
@en
P2093
Aulabaugh A
Jablonski S
McPherson S
Reardon JE
Wakefield JK
P2860
P304
13656-13662
P356
10.1074/JBC.271.23.13656
P407
P577
1996-06-01T00:00:00Z