Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
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Targeting cellular metabolism to improve cancer therapeuticsMetabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implicationNovel therapeutic targets of tumor metabolismDichloroacetate enhances adriamycin-induced hepatoma cell toxicity in vitro and in vivo by increasing reactive oxygen species levelsRegulation of pyruvate metabolism and human diseaseLong-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster.Dichloroacetate induces autophagy in colorectal cancer cells and tumours.Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3.Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α.Dual-targeting of aberrant glucose metabolism in glioblastomaThe anti-leukemic activity of sodium dichloroacetate in p53mutated/null cells is mediated by a p53-independent ILF3/p21 pathwayTargeting of two aspects of metabolism in breast cancer treatment.Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer.High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate.Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1.Overcoming 5-Fu resistance in human non-small cell lung cancer cells by the combination of 5-Fu and cisplatin through the inhibition of glucose metabolism.A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors.Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib.Lysosome dysfunction enhances oxidative stress-induced apoptosis through ubiquitinated protein accumulation in Hela cells.Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect.Inhibition of S6K1 enhances dichloroacetate-induced cell death.
P2860
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P2860
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
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2012 nî lūn-bûn
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2012 թուականին հրատարակուած գիտական յօդուած
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2012 թվականին հրատարակված գիտական հոդված
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2012年の論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年論文
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2012年论文
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name
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
@ast
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
@en
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
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type
label
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
@ast
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
@en
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
@nl
prefLabel
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
@ast
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
@en
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
@nl
P2093
P2860
P1433
P1476
Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage
@en
P2093
Herbert Weissbach
Kasirajan Ayyanathan
Ken Dawson-Scully
Shailaja Kesaraju
P2860
P304
P356
10.1371/JOURNAL.PONE.0039949
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P577
2012-01-01T00:00:00Z