Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage - Wikidata - wikimedia - TriplyDB

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

http://www.wikidata.org/entity/Q28481378

about

Targeting cellular metabolism to improve cancer therapeutics Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implication Novel therapeutic targets of tumor metabolism Dichloroacetate enhances adriamycin-induced hepatoma cell toxicity in vitro and in vivo by increasing reactive oxygen species levels Regulation of pyruvate metabolism and human disease Long-term dietary exposure to low concentration of dichloroacetic acid promoted longevity and attenuated cellular and functional declines in aged Drosophila melanogaster.Dichloroacetate induces autophagy in colorectal cancer cells and tumours.Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3.Pharmacological protection of retinal pigmented epithelial cells by sulindac involves PPAR-α.Dual-targeting of aberrant glucose metabolism in glioblastoma The anti-leukemic activity of sodium dichloroacetate in p53mutated/null cells is mediated by a p53-independent ILF3/p21 pathway Targeting of two aspects of metabolism in breast cancer treatment.Dichloroacetate should be considered with platinum-based chemotherapy in hypoxic tumors rather than as a single agent in advanced non-small cell lung cancer.High-dose vitamin B1 reduces proliferation in cancer cell lines analogous to dichloroacetate.Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1.Overcoming 5-Fu resistance in human non-small cell lung cancer cells by the combination of 5-Fu and cisplatin through the inhibition of glucose metabolism.A phase I open-labeled, single-arm, dose-escalation, study of dichloroacetate (DCA) in patients with advanced solid tumors.Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib.Lysosome dysfunction enhances oxidative stress-induced apoptosis through ubiquitinated protein accumulation in Hela cells.Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect.Inhibition of S6K1 enhances dichloroacetate-induced cell death.

P2860

Q24596727-9D070645-3308-4A3F-8144-E6C7637CA20B Q26795759-7B91AAE6-AD64-479B-B4D4-CBDCF9377CB6 Q27005930-71ADFB1C-F01E-4C8C-A433-C46F357056C5 Q28537767-F7492AE9-3D67-47EF-82BB-258BB9A4397F Q33764544-1B83A34B-BE13-4A47-86CA-EBFA281AFDE6 Q33848626-27E3D88B-8197-4A0E-BA7B-DF9ACE029B7D Q33918095-74A6C83F-62AA-44F3-9A8C-F17A04C37373 Q34100963-1182ED5E-806D-4906-BCBE-674CC8E285AD Q34601724-C839A83C-67EB-4E47-AA77-D6D3C37C18FC Q35073645-5DE190F4-D62B-44CD-AB33-F24C248F3C65 Q35273665-8587BA1C-D697-4155-8729-89FCB4D717D4 Q36213008-6DD28955-D832-415F-814E-4185B41C6EF5 Q37612417-1C60C3FF-CB6D-433C-8E2B-72FF376AE3DE Q38420969-5781A529-2F84-4A59-816A-E03453176E8B Q38787624-E9ABC1B0-0EA9-415A-B0E7-740A1768A215 Q38952954-00560B79-A279-4757-9BB4-91D4F59654BF Q39030297-FC3E2D4F-5FD1-4737-BC3B-2B80A68D0545 Q39175249-9EF1306E-BDF0-40C2-9FC6-F0FA1F05BF35 Q46137587-8FADDC59-4F2D-4BD3-954A-9F765CA244CA Q47996619-F6F9F82C-191B-4E31-9E51-7E05BE1A2E14 Q53677564-D5D8BC77-56E9-4ECF-9897-66E13A665736

P2860

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

http://www.wikidata.org/entity/Q28481378

description

2012 nî lūn-bûn

@nan

2012 թուականին հրատարակուած գիտական յօդուած

@hyw

2012 թվականին հրատարակված գիտական հոդված

@hy

2012年の論文

@ja

2012年論文

@yue

2012年論文

@zh-hant

2012年論文

@zh-hk

2012年論文

@zh-mo

2012年論文

@zh-tw

2012年论文

@wuu

name

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

@ast

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

@en

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

@nl

type

label

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

@ast

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

@en

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

@nl

prefLabel

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

@ast

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

@en

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

@nl

P1433

Q28481378-2E249E84-2782-4E37-BEA1-CE680E2EF603

P1476

Q28481378-2660BBFF-0604-4236-B7CD-E6122121F6CB

P2093

Q28481378-1DF0621C-08AD-4BE8-9478-E3B1558C2901

Q28481378-58D9489C-5297-455A-94A1-78E4293728C7

Q28481378-9A058601-77AF-4EB5-A803-B579554A1C73

Q28481378-CC0A876D-79E6-4972-AB17-B9F7053B71FC

P2860

Q28481378-19C702A8-B3A9-4C75-A8BF-EF8624A5B971

Q28481378-19C737EA-96A0-426A-9FCC-DFA7B2B9EA1D

Q28481378-241034BB-9BEA-48E7-AC5D-9555023E2D8C

Q28481378-27EF8E83-06B4-4BF0-B292-064229E543CA

Q28481378-2995858E-9B5C-48ED-AD26-A0296998B82B

Q28481378-2F62494C-D6FC-4845-9DC6-F0143ED037C0

Q28481378-310FE008-5446-487E-AD3E-46A4592D7464

Q28481378-38AC99C9-D90D-4C7F-8C94-17B9C2A3A93D

Q28481378-403B3240-EC55-4D9A-BA23-A7F0F97EBD86

Q28481378-45A81CBE-268B-45EE-B661-1CD52550B7E7

P304

Q28481378-8F84486A-95AC-4EA6-9901-F6DB3E19302B

P31

Q28481378-429CBB81-52BD-42E4-9A08-ED264963FDA9

P356

Q28481378-6A74A27F-E9E9-47F5-B401-AFF692EA580D

P407

Q28481378-92A84C4C-1572-491A-9157-EC77A3943822

P433

Q28481378-8D1D298B-1C86-4494-8209-D64A4A139BC3

P478

Q28481378-9BC3FD4B-C8F8-4C6A-BC0E-766304DEB401

P577

Q28481378-3B5017DE-66EE-4232-BCCC-F94A6F83ED17

P5875

Q28481378-6D5CB6AE-9AB7-4407-97EB-E699E6525166

P698

Q28481378-420D5619-AE16-4C26-A880-80EBE9AAF69B

P921

Q28481378-FCA0D9CF-7703-4786-AB1A-6ACAA6AAD232

P932

Q28481378-4A979F8B-555A-4667-A025-BD58A85C8458

P356

JOURNAL.PONE.0039949

P1433

P1476

Combination of sulindac and dichloroacetate kills cancer cells via oxidative damage

@en

P2093

Herbert Weissbach

http://www.w3.org/2001/XMLSchema#string

Kasirajan Ayyanathan

http://www.w3.org/2001/XMLSchema#string

Ken Dawson-Scully

http://www.w3.org/2001/XMLSchema#string

Shailaja Kesaraju

http://www.w3.org/2001/XMLSchema#string

P2860

Understanding the Warburg effect: the metabolic requirements of cell proliferation

Role of dichloroacetate in the treatment of genetic mitochondrial diseases

Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer

Brick by brick: metabolism and tumor cell growth

On the Origin of Cancer Cells

Inhibition of lactate dehydrogenase A induces oxidative stress and inhibits tumor progression

Metabolic modulation of glioblastoma with dichloroacetate

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth

Sulindac enhances the killing of cancer cells exposed to oxidative stress

Quantitative analysis of dose-effect relationships: the combined effects of multiple drugs or enzyme inhibitors

P304

e39949

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1371/JOURNAL.PONE.0039949

http://www.w3.org/2001/XMLSchema#string

P407

P433

7

http://www.w3.org/2001/XMLSchema#string

P478

7

http://www.w3.org/2001/XMLSchema#string

P577

2012-01-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

230621153

http://www.w3.org/2001/XMLSchema#string

P698

22866174

http://www.w3.org/2001/XMLSchema#string

P921

dichloroacetate

P932

3398923

http://www.w3.org/2001/XMLSchema#string