Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib.
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Metabolic interplay between glycolysis and mitochondrial oxidation: The reverse Warburg effect and its therapeutic implicationComponents of cancer metabolism and therapeutic interventionsRestoration of mitochondria function as a target for cancer therapyPET Metabolic Biomarkers for CancerDichloroacetate enhances adriamycin-induced hepatoma cell toxicity in vitro and in vivo by increasing reactive oxygen species levelsModulation of cell metabolic pathways and oxidative stress signaling contribute to acquired melphalan resistance in multiple myeloma cellsDichloroacetate induces autophagy in colorectal cancer cells and tumours.Sodium dichloroacetate exhibits anti-leukemic activity in B-chronic lymphocytic leukemia (B-CLL) and synergizes with the p53 activator Nutlin-3.The anti-leukemic activity of sodium dichloroacetate in p53mutated/null cells is mediated by a p53-independent ILF3/p21 pathwayPhase 1 trial of dichloroacetate (DCA) in adults with recurrent malignant brain tumors.Mitochondrial-Targeted Decyl-Triphenylphosphonium Enhances 2-Deoxy-D-Glucose Mediated Oxidative Stress and Clonogenic Killing of Multiple Myeloma CellsMetabolic analysis of radioresistant medulloblastoma stem-like clones and potential therapeutic targetsEffective impairment of myeloma cells and their progenitors by blockade of monocarboxylate transportation.Emerging metabolic targets in the therapy of hematological malignancies.Targeting Negative Surface Charges of Cancer Cells by Multifunctional Nanoprobes.Complex I inhibition augments dichloroacetate cytotoxicity through enhancing oxidative stress in VM-M3 glioblastoma cells.The cationic small molecule GW4869 is cytotoxic to high phosphatidylserine-expressing myeloma cells.Albendazole inhibits HIF-1α-dependent glycolysis and VEGF expression in non-small cell lung cancer cells.Metformin combined with sodium dichloroacetate promotes B leukemic cell death by suppressing anti-apoptotic protein Mcl-1.Polymer nanoparticle delivery of dichloroacetate and DACH-Pt to enhance antitumor efficacy and lower systemic toxicity.IDH1 Mutation Induces Reprogramming of Pyruvate Metabolism.Dichloroacetate, a selective mitochondria-targeting drug for oral squamous cell carcinoma: a metabolic perspective of treatment.NEK2 Promotes Aerobic Glycolysis in Multiple Myeloma Through Regulating Splicing of Pyruvate Kinase.The hypoxia signalling pathway in haematological malignancies.Wnt5a Increases the Glycolytic Rate and the Activity of the Pentose Phosphate Pathway in Cortical Neurons.Mutant IDH1 expression is associated with down-regulation of monocarboxylate transporters.ROS production induced by BRAF inhibitor treatment rewires metabolic processes affecting cell growth of melanoma cellsActivation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis.Dichloroacetate induced intracellular acidification in glioblastoma: in vivo detection using AACID-CEST MRI at 9.4 Tesla.Glucose Metabolism in Cancer and Ischemia: Possible Therapeutic Consequences of the Warburg Effect.AKT-independent activation of p38 MAP kinase promotes vascular calcification.The effect of dichloroacetate on male rat thymus and on thymocyte cell cycle.Inhibition of S6K1 enhances dichloroacetate-induced cell death.Metabolic Features of Multiple Myeloma.Effects of dichloroacetate as single agent or in combination with GW6471 and metformin in paraganglioma cellsThe Influence of Metabolism on Drug Response in Cancer
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P2860
Dichloroacetate inhibits aerobic glycolysis in multiple myeloma cells and increases sensitivity to bortezomib.
description
2013 nî lūn-bûn
@nan
2013年の論文
@ja
2013年論文
@yue
2013年論文
@zh-hant
2013年論文
@zh-hk
2013年論文
@zh-mo
2013年論文
@zh-tw
2013年论文
@wuu
2013年论文
@zh
2013年论文
@zh-cn
name
Dichloroacetate inhibits aerob ...... ses sensitivity to bortezomib.
@en
Dichloroacetate inhibits aerob ...... ses sensitivity to bortezomib.
@nl
type
label
Dichloroacetate inhibits aerob ...... ses sensitivity to bortezomib.
@en
Dichloroacetate inhibits aerob ...... ses sensitivity to bortezomib.
@nl
prefLabel
Dichloroacetate inhibits aerob ...... ses sensitivity to bortezomib.
@en
Dichloroacetate inhibits aerob ...... ses sensitivity to bortezomib.
@nl
P2093
P2860
P50
P356
P1476
Dichloroacetate inhibits aerob ...... ases sensitivity to bortezomib
@en
P2093
P2860
P2888
P304
P356
10.1038/BJC.2013.120
P407
P577
2013-03-26T00:00:00Z