Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
about
Huntingtin is critical both pre- and postsynaptically for long-term learning-related synaptic plasticity in AplysiaMouse models of polyglutamine diseases: review and data table. Part IInhibition of mTOR induces autophagy and reduces toxicity of polyglutamine expansions in fly and mouse models of Huntington diseaseHuntingtin and its role in neuronal degenerationA Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in miceAmyloid oligomer neurotoxicity, calcium dysregulation, and lipid raftsUp-regulating BDNF with an ampakine rescues synaptic plasticity and memory in Huntington's disease knockin mice.Wheel running from a juvenile age delays onset of specific motor deficits but does not alter protein aggregate density in a mouse model of Huntington's disease.Progressive synaptic pathology of motor cortical neurons in a BAC transgenic mouse model of Huntington's disease.Imbalanced pattern completion vs. separation in cognitive disease: network simulations of synaptic pathologies predict a personalized therapeutics strategy.Of mice and men: solving the molecular mysteries of Huntington's disease.Mitochondria and neuroplasticity.Cysteine string protein (CSP) inhibition of N-type calcium channels is blocked by mutant huntingtin.Abnormal motor cortex plasticity in premanifest and very early manifest Huntington diseaseLong-Term Potentiation at CA3-CA1 Hippocampal Synapses with Special Emphasis on Aging, Disease, and Stress.Striatal synaptic dysfunction and hippocampal plasticity deficits in the Hu97/18 mouse model of Huntington diseaseCombination of methamphetamine and HIV-1 gp120 causes distinct long-term alterations of behavior, gene expression, and injury in the central nervous system.Differential Changes in Postsynaptic Density Proteins in Postmortem Huntington's Disease and Parkinson's Disease Human Brains.Dysfunction of the ubiquitin ligase Ube3a may be associated with synaptic pathophysiology in a mouse model of Huntington diseaseNovel therapeutic targets for Huntington's disease.Knock-in mouse models of Huntington's disease.Suppression of neurodegeneration and increased neurotransmission caused by expanded full-length huntingtin accumulating in the cytoplasmImpaired ubiquitin-proteasome system activity in the synapses of Huntington's disease mice.The corticostriatal pathway in Huntington's disease.The substrates of memory: defects, treatments, and enhancement.Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease.Severe neurological phenotypes of Q129 DRPLA transgenic mice serendipitously created by en masse expansion of CAG repeats in Q76 DRPLA mice.Memory and synaptic deficits in Hip14/DHHC17 knockout mice.XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis.Suppressing aberrant GluN3A expression rescues synaptic and behavioral impairments in Huntington's disease models.Brain networks in Huntington disease.Huntington's disease: can mice lead the way to treatment?Involvement of kynurenines in Huntington's disease and stroke-induced brain damage.The Role of Striatal-Enriched Protein Tyrosine Phosphatase (STEP) in Cognition.The role of dopamine in Huntington's disease.More alive than dead: non-apoptotic roles for caspases in neuronal development, plasticity and disease.Hippocampal dysfunction defines disease onset in Huntington's disease.Huntington's Disease: Mechanisms of Pathogenesis and Therapeutic Strategies.Sp1 regulates human huntingtin gene expression.Systematic uncovering of multiple pathways underlying the pathology of Huntington disease by an acid-cleavable isotope-coded affinity tag approach.
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P2860
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
description
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
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im Mai 1999 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
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vedecký článok (publikovaný 1999/05/01)
@sk
vědecký článek publikovaný v roce 1999
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wetenschappelijk artikel (gepubliceerd op 1999/05/01)
@nl
наукова стаття, опублікована в травні 1999
@uk
مقالة علمية (نشرت في مايو 1999)
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name
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
@ast
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
@en
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
@nl
type
label
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
@ast
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
@en
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
@nl
prefLabel
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
@ast
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
@en
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
@nl
P2093
P2860
P356
P1476
Impaired synaptic plasticity in mice carrying the Huntington's disease mutation
@en
P2093
D. V. Madison
M. T. Usdin
P. F. Shelbourne
R. M. Myers
P2860
P304
P356
10.1093/HMG/8.5.839
P577
1999-05-01T00:00:00Z