Huntington's disease: can mice lead the way to treatment?
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Shaping action sequences in basal ganglia circuitsCRISPR/Cas9: a powerful genetic engineering tool for establishing large animal models of neurodegenerative diseasesTransgenic animal models for study of the pathogenesis of Huntington's disease and therapyMouse models of polyglutamine diseases: review and data table. Part IPluripotent stem cells models for Huntington's disease: prospects and challengesIntrabodies as neuroprotective therapeuticsThe N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model.Mutant huntingtin gene-dose impacts on aggregate deposition, DARPP32 expression and neuroinflammation in HdhQ150 miceCell-based screening: extracting meaning from complex data.N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic miceHuman-to-mouse prion-like propagation of mutant huntingtin protein.SIRT2 ablation has no effect on tubulin acetylation in brain, cholesterol biosynthesis or the progression of Huntington's disease phenotypes in vivoAssessment of motor function, sensory motor gating and recognition memory in a novel BACHD transgenic rat model for huntington disease.Reversal learning and associative memory impairments in a BACHD rat model for Huntington diseaseGenetic knock-down of HDAC3 does not modify disease-related phenotypes in a mouse model of Huntington's diseaseHdac6 knock-out increases tubulin acetylation but does not modify disease progression in the R6/2 mouse model of Huntington's diseaseSorCS2-mediated NR2A trafficking regulates motor deficits in Huntington's diseaseAblation of huntingtin in adult neurons is nondeleterious but its depletion in young mice causes acute pancreatitis.Huntingtin is required for normal excitatory synapse development in cortical and striatal circuitsProteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis.Sex-dependent changes in social behaviors in motor pre-symptomatic R6/1 mice.Longitudinal transcriptomic dysregulation in the peripheral blood of transgenic Huntington's disease monkeys.A two years longitudinal study of a transgenic Huntington disease monkey.Neuronal targets for reducing mutant huntingtin expression to ameliorate disease in a mouse model of Huntington's diseaseMotivational, proteostatic and transcriptional deficits precede synapse loss, gliosis and neurodegeneration in the B6.HttQ111/+ model of Huntington's disease.Oligonucleotide-based strategies to combat polyglutamine diseases.Differential Alteration in Expression of Striatal GABAAR Subunits in Mouse Models of Huntington's DiseaseAn aggregation sensing reporter identifies leflunomide and teriflunomide as polyglutamine aggregate inhibitors.Skeletal muscle pathology in Huntington's diseaseDifferential nuclear localization of complexes may underlie in vivo intrabody efficacy in Huntington's disease.Cryopreservation of transgenic Huntington's disease rhesus macaque sperm-A Case ReportCharacterisation of immune cell function in fragment and full-length Huntington's disease mouse modelsStriatal pre-enkephalin overexpression improves Huntington's disease symptoms in the R6/2 mouse model of Huntington's diseaseReduced expression of conditioned fear in the R6/2 mouse model of Huntington's disease is related to abnormal activity in prelimbic cortex.Phosphorylation of mutant huntingtin at serine 116 modulates neuronal toxicity.Advances in reprogramming-based study of neurologic disordersImpaired import: how huntingtin harms.Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD.Similar striatal gene expression profiles in the striatum of the YAC128 and HdhQ150 mouse models of Huntington's disease are not reflected in mutant Huntingtin inclusion prevalence.
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Huntington's disease: can mice lead the way to treatment?
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article científic
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article scientifique
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articolo scientifico
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artigo científico
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bilimsel makale
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scientific article published on February 2011
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vedecký článok
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vetenskaplig artikel
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videnskabelig artikel
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vědecký článek
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name
Huntington's disease: can mice lead the way to treatment?
@en
Huntington's disease: can mice lead the way to treatment?
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type
label
Huntington's disease: can mice lead the way to treatment?
@en
Huntington's disease: can mice lead the way to treatment?
@nl
prefLabel
Huntington's disease: can mice lead the way to treatment?
@en
Huntington's disease: can mice lead the way to treatment?
@nl
P2860
P1433
P1476
Huntington's disease: can mice lead the way to treatment?
@en
P2093
David Housman
Zachary R Crook
P2860
P304
P356
10.1016/J.NEURON.2010.12.035
P407
P577
2011-02-01T00:00:00Z