A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice
about
Rhes, a striatal specific protein, mediates mutant-huntingtin cytotoxicityTransgenic animal models for study of the pathogenesis of Huntington's disease and therapyMouse models of polyglutamine diseases: review and data table. Part IIdentification of RTG2 as a modifier gene for CTG*CAG repeat instability in Saccharomyces cerevisiaeA broad phenotypic screen identifies novel phenotypes driven by a single mutant allele in Huntington's disease CAG knock-in mice.Impaired synaptic plasticity in mice carrying the Huntington's disease mutationThe operant serial implicit learning task reveals early onset motor learning deficits in the Hdh knock-in mouse model of Huntington's diseaseCellular localization and development of neuronal intranuclear inclusions in striatal and cortical neurons in R6/2 transgenic miceOnset and progression of behavioral and molecular phenotypes in a novel congenic R6/2 line exhibiting intergenerational CAG repeat stability.Mouse models of Huntington's disease and methodological considerations for therapeutic trials.Forging links between human mental retardation-associated CNVs and mouse gene knockout models.Stem Cells Transplantation and Huntington's DiseaseHuntington disease models and human neuropathology: similarities and differencesOf mice and men: solving the molecular mysteries of Huntington's disease.Early autophagic response in a novel knock-in model of Huntington diseaseA recurrent expansion of a maternal allele with 36 CAG repeats causes Huntington disease in two sistersThe selective vulnerability of nerve cells in Huntington's disease.Role of ubiquitin-proteasome-mediated proteolysis in nervous system disease.MSH3 polymorphisms and protein levels affect CAG repeat instability in Huntington's disease miceTransgenic animal models of neurodegeneration based on human genetic studies.Altered Balance of Activity in the Striatal Direct and Indirect Pathways in Mouse Models of Huntington's DiseaseA knockin mouse model of spinocerebellar ataxia type 3 exhibits prominent aggregate pathology and aberrant splicing of the disease gene transcript.Clinical and research advances in Huntington's disease.A novel GAA-repeat-expansion-based mouse model of Friedreich's ataxiaAltered excitatory and inhibitory inputs to striatal medium-sized spiny neurons and cortical pyramidal neurons in the Q175 mouse model of Huntington's disease.CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse.Experimental therapeutics in transgenic mouse models of Huntington's disease.Transgenic mouse model expressing the caspase 6 fragment of mutant huntingtin.Translating therapies for Huntington's disease from genetic animal models to clinical trials.Novel BAC Mouse Model of Huntington's Disease with 225 CAG Repeats Exhibits an Early Widespread and Stable Degenerative Phenotype.Knock-in mouse models of Huntington's disease.Quantitative Electroencephalographic Analysis Provides an Early-Stage Indicator of Disease Onset and Progression in the zQ175 Knock-In Mouse Model of Huntington's Disease.Animal models of Huntington's disease: implications in uncovering pathogenic mechanisms and developing therapies.The corticostriatal pathway in Huntington's disease.Multiple pathways contribute to the pathogenesis of Huntington disease.Transcriptional signatures in Huntington's disease.Therapeutic perspectives for the treatment of Huntington's disease: treating the whole bodyGenetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice.Genetic mouse models of Huntington's disease: focus on electrophysiological mechanisms.Molecular mechanisms and potential therapeutical targets in Huntington's disease.
P2860
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P2860
A Huntington's disease CAG expansion at the murine Hdh locus is unstable and associated with behavioural abnormalities in mice
description
1999 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մայիսին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 1999
@ast
im Mai 1999 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1999/05/01)
@sk
vědecký článek publikovaný v roce 1999
@cs
wetenschappelijk artikel (gepubliceerd op 1999/05/01)
@nl
наукова стаття, опублікована в травні 1999
@uk
مقالة علمية (نشرت في مايو 1999)
@ar
name
A Huntington's disease CAG exp ...... avioural abnormalities in mice
@ast
A Huntington's disease CAG exp ...... avioural abnormalities in mice
@en
A Huntington's disease CAG exp ...... avioural abnormalities in mice
@nl
type
label
A Huntington's disease CAG exp ...... avioural abnormalities in mice
@ast
A Huntington's disease CAG exp ...... avioural abnormalities in mice
@en
A Huntington's disease CAG exp ...... avioural abnormalities in mice
@nl
prefLabel
A Huntington's disease CAG exp ...... avioural abnormalities in mice
@ast
A Huntington's disease CAG exp ...... avioural abnormalities in mice
@en
A Huntington's disease CAG exp ...... avioural abnormalities in mice
@nl
P2093
P2860
P356
P1476
A Huntington's disease CAG exp ...... avioural abnormalities in mice
@en
P2093
C. Iannicola
D. R. Littman
H. M. Johnston
L. Ramirez
M. Lewandoski
N. Killeen
P. F. Shelbourne
R. F. Hevner
P2860
P304
P356
10.1093/HMG/8.5.763
P577
1999-05-01T00:00:00Z