Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit
about
The GNAS complex locus and human diseases associated with loss-of-function mutations or epimutations within this imprinted geneGene Dosage Effects at the Imprinted Gnas ClusterDeficiency of the G-protein alpha-subunit G(s)alpha in osteoblasts leads to differential effects on trabecular and cortical boneTransgenic overexpression of the extra-large Gsα variant XLαs enhances Gsα-mediated responses in the mouse renal proximal tubule in vivoDifferential genomic imprinting and expression of imprinted microRNAs in testes-derived male germ-line stem cells in mouseImpact of the genome on the epigenome is manifested in DNA methylation patterns of imprinted regions in monozygotic and dizygotic twinsAlternative Gnas gene products have opposite effects on glucose and lipid metabolism.Uncoupling antisense-mediated silencing and DNA methylation in the imprinted Gnas cluster.Allele-specific H3K79 Di- versus trimethylation distinguishes opposite parental alleles at imprinted regionsConventional and novel Gγ protein families constitute the heterotrimeric G-protein signaling network in soybeanDeletion of the noncoding GNAS antisense transcript causes pseudohypoparathyroidism type Ib and biparental defects of GNAS methylation in cisThe role of GNAS and other imprinted genes in the development of obesity.Postnatal changes in the expression pattern of the imprinted signalling protein XLαs underlie the changing phenotype of deficient mice.Methylation defect in imprinted genes detected in patients with an Albright's hereditary osteodystrophy like phenotype and platelet Gs hypofunctionA mouse model for osseous heteroplasiaEffects of deficiency of the G protein Gsα on energy and glucose homeostasisOntogeny of CpG island methylation and specificity of DNMT3 methyltransferases during embryonic development in the mouse.Transcription driven somatic DNA methylation within the imprinted Gnas clusterIdentification of a novel mutation in a pseudohypoparathyroidism familyImprinting status of Galpha(s), NESP55, and XLalphas in cell cultures derived from human embryonic germ cells: GNAS imprinting in human embryonic germ cellsNew mutations at the imprinted Gnas cluster show gene dosage effects of Gsα in postnatal growth and implicate XLαs in bone and fat metabolism but not in suckling.Skeletal progenitors and the GNAS gene: fibrous dysplasia of bone read through stem cells.Studies of the regulation and function of the Gs alpha gene Gnas using gene targeting technology.Development and treatment of tertiary hyperparathyroidism in patients with pseudohypoparathyroidism type 1BDNA methylation at differentially methylated regions of imprinted genes is resistant to developmental programming by maternal nutrition.Non-Coding RNAs at the Gnas and Snrpn-Ube3a Imprinted Gene Loci and Their Involvement in Hereditary Disorders.Origins of extreme sexual dimorphism in genomic imprinting.Severe obesity and insulin resistance due to deletion of the maternal Gsalpha allele is reversed by paternal deletion of the Gsalpha imprint control region.Transcription is required for establishment of germline methylation marks at imprinted genesThe GNAS Locus: Quintessential Complex Gene Encoding Gsalpha, XLalphas, and other Imprinted TranscriptsProtection against de novo methylation is instrumental in maintaining parent-of-origin methylation inherited from the gametesPhysiological dysfunctions associated with mutations of the imprinted Gnas locus.Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissuesMale-Specific Transcription Factor Occupancy Alone Does Not Account for Differential Methylation at Imprinted Genes in the mouse Germ Cell Lineage.Follow-up Findings in a Turkish Girl with Pseudohypoparathyroidism Type Ia Caused by a Novel Heterozygous Mutation in the GNAS Gene.GNAS mutations in Pseudohypoparathyroidism type 1a and related disorders.GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.WAMIDEX: a web atlas of murine genomic imprinting and differential expression.Role of the Dnmt3 family in de novo methylation of imprinted and repetitive sequences during male germ cell development in the mouse.G-protein complex mutants are hypersensitive to abscisic acid regulation of germination and postgermination development.
P2860
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P2860
Identification of the control region for tissue-specific imprinting of the stimulatory G protein alpha-subunit
description
2005 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans les Procee ...... f the United States of America
@fr
artículu científicu espublizáu en 2005
@ast
im April 2005 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2005/04/12)
@sk
vědecký článek publikovaný v roce 2005
@cs
wetenschappelijk artikel (gepubliceerd op 2005/04/12)
@nl
наукова стаття, опублікована у квітні 2005
@uk
name
Identification of the control ...... latory G protein alpha-subunit
@ast
Identification of the control ...... latory G protein alpha-subunit
@en
Identification of the control ...... latory G protein alpha-subunit
@nl
type
label
Identification of the control ...... latory G protein alpha-subunit
@ast
Identification of the control ...... latory G protein alpha-subunit
@en
Identification of the control ...... latory G protein alpha-subunit
@nl
prefLabel
Identification of the control ...... latory G protein alpha-subunit
@ast
Identification of the control ...... latory G protein alpha-subunit
@en
Identification of the control ...... latory G protein alpha-subunit
@nl
P2093
P2860
P3181
P356
P1476
Identification of the control ...... latory G protein alpha-subunit
@en
P2093
Beth Erlichman
Chuxia Deng
Déborah Bourc'his
Julie G. Nealon
Lee S. Weinstein
Timothy H. Bestor
P2860
P304
P3181
P356
10.1073/PNAS.0408262102
P407
P577
2005-04-12T00:00:00Z