Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes
about
Endofin, an endosomal FYVE domain proteinPIKfyve controls fluid phase endocytosis but not recycling/degradation of endocytosed receptors or sorting of procathepsin D by regulating multivesicular body morphogenesisThe mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport.Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport. Novel Sac phosphatase joins the ArPIKfyve-PIKfyve complexThe Phox homology (PX) domain, a new player in phosphoinositide signallingMutations in PIP5K3 are associated with François-Neetens mouchetée fleck corneal dystrophyA mammalian ortholog of Saccharomyces cerevisiae Vac14 that associates with and up-regulates PIKfyve phosphoinositide 5-kinase activityPIKfyve: Partners, significance, debates and paradoxesArPIKfyve-PIKfyve interaction and role in insulin-regulated GLUT4 translocation and glucose transport in 3T3-L1 adipocytesPhosphatidylinositol 3,5-bisphosphate: low abundance, high significanceIdentification of mammalian Vps24p as an effector of phosphatidylinositol 3,5-bisphosphate-dependent endosome compartmentalizationPhosphatidylinositol 3-phosphate-interacting domains in PIKfyve. Binding specificity and role in PIKfyve. Endomenbrane localizationActive PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 5-kinase PIKfyvePIKfyve negatively regulates exocytosis in neurosecretory cellsLocalized PtdIns 3,5-P2 synthesis to regulate early endosome dynamics and fusionGenetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.N-terminal protein acylation confers localization to cholesterol, sphingolipid-enriched membranes but not to lipid rafts/caveolae.Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity.Sac3 is an insulin-regulated phosphatidylinositol 3,5-bisphosphate phosphatase: gain in insulin responsiveness through Sac3 down-regulation in adipocytesClass III PI 3-kinase is the main source of PtdIns3P substrate and membrane recruitment signal for PIKfyve constitutive function in podocyte endomembrane homeostasisPtdIns5P: news and views of its appearance, disappearance and deeds.Pathomechanisms of mutant proteins in Charcot-Marie-Tooth disease.Phosphoinositides in insulin action on GLUT4 dynamics: not just PtdIns(3,4,5)P3.The CMT4B disease-causing proteins MTMR2 and MTMR13/SBF2 regulate AKT signallingPairing phosphoinositides with calcium ions in endolysosomal dynamics: phosphoinositides control the direction and specificity of membrane trafficking by regulating the activity of calcium channels in the endolysosomes.PIKfyve inhibition interferes with phagosome and endosome maturation in macrophages.Phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) is an AMPK target participating in contraction-stimulated glucose uptake in skeletal muscle.Distinct Requirements for Vacuolar Protein Sorting 34 Downstream Effector Phosphatidylinositol 3-Phosphate 5-Kinase in Podocytes Versus Proximal Tubular Cells.PIKfyve Kinase and SKD1 AAA ATPase define distinct endocytic compartments. Only PIKfyve expression inhibits the cell-vacoulating activity of Helicobacter pylori VacA toxin.Hepatic deletion of p110α and p85α results in insulin resistance despite sustained IRS1-associated phosphatidylinositol kinase activity.
P2860
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P2860
Localization and insulin-regulated relocation of phosphoinositide 5-kinase PIKfyve in 3T3-L1 adipocytes
description
2001 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2001 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2001
@ast
im April 2001 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2001/04/13)
@sk
vědecký článek publikovaný v roce 2001
@cs
wetenschappelijk artikel (gepubliceerd op 2001/04/13)
@nl
наукова стаття, опублікована у квітні 2001
@uk
name
Localization and insulin-regul ...... e PIKfyve in 3T3-L1 adipocytes
@ast
Localization and insulin-regul ...... e PIKfyve in 3T3-L1 adipocytes
@en
Localization and insulin-regul ...... e PIKfyve in 3T3-L1 adipocytes
@nl
type
label
Localization and insulin-regul ...... e PIKfyve in 3T3-L1 adipocytes
@ast
Localization and insulin-regul ...... e PIKfyve in 3T3-L1 adipocytes
@en
Localization and insulin-regul ...... e PIKfyve in 3T3-L1 adipocytes
@nl
prefLabel
Localization and insulin-regul ...... e PIKfyve in 3T3-L1 adipocytes
@ast
Localization and insulin-regul ...... e PIKfyve in 3T3-L1 adipocytes
@en
Localization and insulin-regul ...... e PIKfyve in 3T3-L1 adipocytes
@nl
P2093
P2860
P356
P1476
Localization and insulin-regul ...... e PIKfyve in 3T3-L1 adipocytes
@en
P2093
A. Shisheva
C. DeMarco
D. Sbrissa
O. C. Ikonomov
P2860
P304
11859–11869
P356
10.1074/JBC.M008437200
P407
P577
2001-04-13T00:00:00Z