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Ubiquitylation of autophagy receptor Optineurin by HACE1 activates selective autophagy for tumor suppressionFunctional analysis of optineurin and some of its disease-associated mutantsMitochondrial pathogenic mechanism and degradation in optineurin E50K mutation-mediated retinal ganglion cell degenerationA Glaucoma-Associated Variant of Optineurin, M98K, Activates Tbk1 to Enhance Autophagosome Formation and Retinal Cell Death Dependent on Ser177 Phosphorylation of OptineurinM98K-OPTN induces transferrin receptor degradation and RAB12-mediated autophagic death in retinal ganglion cellsLacritin and other autophagy associated proteins in ocular surface health.Autophagy in the eye: implications for ocular cell health.Optineurin immunoreactivity in neuronal and glial intranuclear inclusions in adult-onset neuronal intranuclear inclusion disease.E50K-OPTN-induced retinal cell death involves the Rab GTPase-activating protein, TBC1D17 mediated block in autophagy.Cellular processing of myocilin.Induction of autophagy in rats upon overexpression of wild-type and mutant optineurin gene.Optineurin regulates the interferon response in a cell cycle-dependent mannerOptineurin: The autophagy connection.Genes, pathways, and animal models in primary open-angle glaucoma.Cellular and molecular biology of optineurin.Ankyrin repeat and suppressor of cytokine signaling box containing protein-10 is associated with ubiquitin-mediated degradation pathways in trabecular meshwork cells.Myocilin and Optineurin: Differential Characteristics and Functional ConsequencesRapamycin increases survival in ALS mice lacking mature lymphocytes.Effects of mutations and deletions in the human optineurin gene.Molecular genetics in glaucoma.Familial amyotrophic lateral sclerosis, a historical perspective.Genetic determinants of Paget's disease of bone.Toward an integrative view of Optineurin functions.Protein aggregation in amyotrophic lateral sclerosis.The cell stress machinery and retinal degeneration.Interaction between optineurin and Rab1a regulates autophagosome formation in neuroblastoma cells.The fine-tuning of proteolytic pathways in Alzheimer's disease.Working your SOCS off: The role of ASB10 and protein degradation pathways in glaucoma.A yeast model of optineurin proteinopathy reveals a unique aggregation pattern associated with cellular toxicity.Inhibition of the classical pathway of the complement cascade prevents early dendritic and synaptic degeneration in glaucoma.Yeast genetic interaction screen of human genes associated with amyotrophic lateral sclerosis: identification of MAP2K5 kinase as a potential drug targetFrom the Cover: Alterations in Optineurin Expression and Localization in Pre-clinical Parkinson's Disease ModelsEnhanced optineurin E50K-TBK1 interaction evokes protein insolubility and initiates familial primary open-angle glaucoma.Rilmenidine promotes MTOR-independent autophagy in the mutant SOD1 mouse model of amyotrophic lateral sclerosis without slowing disease progression.661W is a retinal ganglion precursor-like cell line in which glaucoma-associated optineurin mutants induce cell death selectively.Optineurin promotes autophagosome formation by recruiting the autophagy-related Atg12-5-16L1 complex to phagophores containing the Wipi2 protein.Glaucoma pathogenesis and neurotrophins: Focus on the Molecular and Genetic basis for Therapeutic prospects.Optineurin: A Coordinator of Membrane-Associated Cargo Trafficking and Autophagy.Altered Functions and Interactions of Glaucoma-Associated Mutants of Optineurin.Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer.
P2860
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P2860
description
2011 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2011 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 2011
@ast
im Februar 2011 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 2011/02/04)
@sk
vědecký článek publikovaný v roce 2011
@cs
wetenschappelijk artikel (gepubliceerd op 2011/02/04)
@nl
наукова стаття, опублікована в лютому 2011
@uk
name
Processing of optineurin in neuronal cells
@ast
Processing of optineurin in neuronal cells
@en
Processing of optineurin in neuronal cells
@nl
type
label
Processing of optineurin in neuronal cells
@ast
Processing of optineurin in neuronal cells
@en
Processing of optineurin in neuronal cells
@nl
prefLabel
Processing of optineurin in neuronal cells
@ast
Processing of optineurin in neuronal cells
@en
Processing of optineurin in neuronal cells
@nl
P2093
P2860
P3181
P356
P1476
Processing of optineurin in neuronal cells
@en
P2093
Beatrice Y. J. T. Yue
Hongyu Ying
Jeong-Seok Park
Rajalekshmy Shyam
Takeshi Iwata
Xiang Shen
Zai-Long Chi
P2860
P304
P3181
P356
10.1074/JBC.M110.175810
P407
P577
2011-02-04T00:00:00Z