Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII
about
Evidence for a minimal eukaryotic phosphoproteome?The kinase DYRK1A phosphorylates the transcription factor FKHR at Ser329 in vitro, a novel in vivo phosphorylation siteThe kinase DYRK phosphorylates protein-synthesis initiation factor eIF2Bepsilon at Ser539 and the microtubule-associated protein tau at Thr212: potential role for DYRK as a glycogen synthase kinase 3-priming kinaseMirk protein kinase is activated by MKK3 and functions as a transcriptional activator of HNF1alphaDirect association of Sprouty-related protein with an EVH1 domain (SPRED) 1 or SPRED2 with DYRK1A modifies substrate/kinase interactionsPhosphorylation of Ser640 in muscle glycogen synthase by DYRK family protein kinasesRegulation of MBK-2/DYRK by CDK-1 and the pseudophosphatases EGG-4 and EGG-5 during the oocyte-to-embryo transitionRegulation of RCAN1 protein activity by Dyrk1A protein-mediated phosphorylationdDYRK2: a novel dual-specificity tyrosine-phosphorylation-regulated kinase in DrosophilaMirk/Dyrk1B mediates survival during the differentiation of C2C12 myoblastsActivation of androgen receptor function by a novel nuclear protein kinaseOverexpression of the human MNB/DYRK1A gene induces formation of multinucleate cells through overduplication of the centrosomeMouse models of Down syndrome as a tool to unravel the causes of mental disabilitiesRegulation of yeast Yak1 kinase by PKA and autophosphorylation-dependent 14-3-3 binding.Dual specificity protein kinase activity of testis-specific protein kinase 1 and its regulation by autophosphorylation of serine-215 within the activation loopCloning and expression of a novel MAPKK-like protein kinase, lymphokine-activated killer T-cell-originated protein kinase, specifically expressed in the testis and activated lymphoid cellsCharacterization of cyclin L2, a novel cyclin with an arginine/serine-rich domain: phosphorylation by DYRK1A and colocalization with splicing factorsDynamin is a minibrain kinase/dual specificity Yak1-related kinase 1A substrateFunctional screening of 2 Mb of human chromosome 21q22.2 in transgenic mice implicates minibrain in learning defects associated with Down syndromeIdentification of the autophosphorylation sites and characterization of their effects in the protein kinase DYRK1ALapatinib-binding protein kinases in the African trypanosome: identification of cellular targets for kinase-directed chemical scaffoldsDyrk1A potentiates steroid hormone-induced transcription via the chromatin remodeling factor Arip4DYRK1A enhances the mitogen-activated protein kinase cascade in PC12 cells by forming a complex with Ras, B-Raf, and MEK1.DYRK3 activation, engagement of protein kinase A/cAMP response element-binding protein, and modulation of progenitor cell survivalSelective inhibition of the kinase DYRK1A by targeting its folding processInteraction of the E1A oncoprotein with Yak1p, a novel regulator of yeast pseudohyphal differentiation, and related mammalian kinases.Dyrk1A haploinsufficiency affects viability and causes developmental delay and abnormal brain morphology in miceSurvey of phosphorylation near drug binding sites in the Protein Data Bank (PDB) and their effects.The phosphoproteome of bloodstream form Trypanosoma brucei, causative agent of African sleeping sicknessMirk/Dyrk1B maintains the viability of quiescent pancreatic cancer cells by reducing levels of reactive oxygen species.Dyrk1A overexpression leads to increase of 3R-tau expression and cognitive deficits in Ts65Dn Down syndrome miceMechanisms of tau-induced neurodegeneration.Roles of the DYRK kinase Pom2 in cytokinesis, mitochondrial morphology, and sporulation in fission yeast.Deep evolutionary conservation of an intramolecular protein kinase activation mechanism.The transcriptional activator Mirk/Dyrk1B is sequestered by p38alpha/beta MAP kinase.Characterization of Caenorhabditis elegans homologs of the Down syndrome candidate gene DYRK1A.Phosphorylation by Dyrk1A of clathrin coated vesicle-associated proteins: identification of the substrate proteins and the effects of phosphorylation.Depleting Mirk Kinase Increases Cisplatin Toxicity in Ovarian Cancer Cells.Inhibition of RIP2's tyrosine kinase activity limits NOD2-driven cytokine responses.The role of DYRK1A in neurodegenerative diseases.
P2860
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P2860
Dyrk, a dual specificity protein kinase with unique structural features whose activity is dependent on tyrosine residues between subdomains VII and VIII
description
1996 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
1996 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
article publié dans la revue scientifique Journal of Biological Chemistry
@fr
artículu científicu espublizáu en 1996
@ast
im Februar 1996 veröffentlichter wissenschaftlicher Artikel
@de
scientific journal article
@en
vedecký článok (publikovaný 1996/02/16)
@sk
vědecký článek publikovaný v roce 1996
@cs
wetenschappelijk artikel (gepubliceerd op 1996/02/16)
@nl
наукова стаття, опублікована в лютому 1996
@uk
name
Dyrk, a dual specificity prote ...... etween subdomains VII and VIII
@ast
Dyrk, a dual specificity prote ...... etween subdomains VII and VIII
@en
Dyrk, a dual specificity prote ...... etween subdomains VII and VIII
@nl
type
label
Dyrk, a dual specificity prote ...... etween subdomains VII and VIII
@ast
Dyrk, a dual specificity prote ...... etween subdomains VII and VIII
@en
Dyrk, a dual specificity prote ...... etween subdomains VII and VIII
@nl
prefLabel
Dyrk, a dual specificity prote ...... etween subdomains VII and VIII
@ast
Dyrk, a dual specificity prote ...... etween subdomains VII and VIII
@en
Dyrk, a dual specificity prote ...... etween subdomains VII and VIII
@nl
P2093
P3181
P356
P1476
Dyrk, a dual specificity prote ...... etween subdomains VII and VIII
@en
P2093
A. Schürmann
C. Huppertz
H. G. Joost
H. Kentrup
J. Heukelbach
P304
P3181
P356
10.1074/JBC.271.7.3488
P407
P577
1996-02-16T00:00:00Z